Sugi Variant

Sugi Variant/BAG5

BAG5 — 83 ClinVar variants

All ClinVar germline BAG5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 60 flagged for review →

2 Pathogenic · 3 Likely pathogenic · 6 Likely benign · 72 Uncertain significance

Full BAG5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 60

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 33

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 27

The independent predictors disagree with each other — read with care.

All BAG5 variants

Pathogenic 2

  • p.Arg197Ter No assertion criteria cardiomyopathy, dilated, 2F
  • p.His7fs No assertion criteria cardiomyopathy, dilated, 2F

Likely pathogenic 3

  • p.Arg390Ter Single submitter cardiomyopathy, dilated, 2F
  • p.His136fs Single submitter cardiomyopathy, dilated, 2F
  • p.Lys108fs No assertion criteria cardiomyopathy

Likely benign 6

Uncertain significance 72