BAG6 — 83 ClinVar variants
All ClinVar germline BAG6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 70 flagged for review →
4 Benign · 8 Likely benign · 71 Uncertain significance
Full BAG6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 70
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 42
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- BAG6 p.Gln1137Glu Uncertain significance Multiple submitters
- BAG6 p.Ala1101Val Uncertain significance Single submitter
- BAG6 p.Ala261Val Uncertain significance Single submitter
- BAG6 p.Arg1107Gln Uncertain significance Single submitter
- BAG6 p.Arg1133Gln Uncertain significance Single submitter
- BAG6 p.Arg1156Gln Uncertain significance Single submitter
- BAG6 p.Arg118Gln Uncertain significance Single submitter
- BAG6 p.Arg186Gln Uncertain significance Single submitter
- BAG6 p.Arg279Gln Uncertain significance Single submitter
- BAG6 p.Arg290Cys Uncertain significance Single submitter
- BAG6 p.Arg439Trp Uncertain significance Single submitter
- BAG6 p.Arg749Gln Uncertain significance Single submitter
- BAG6 p.Arg816Leu Uncertain significance Single submitter
- BAG6 p.Arg928Gln Uncertain significance Single submitter
- BAG6 p.Arg934His Uncertain significance Single submitter
- BAG6 p.Asn1153Ser Uncertain significance Single submitter
- BAG6 p.Asn413His Uncertain significance Single submitter
- BAG6 p.Asn564Ser Uncertain significance Single submitter
- BAG6 p.Gln1155Arg Uncertain significance Single submitter
- BAG6 p.Gln456Arg Uncertain significance Single submitter
- BAG6 p.Gly112Val Uncertain significance Single submitter
- BAG6 p.Gly144Ser Uncertain significance Single submitter
- BAG6 p.Ile52Val Uncertain significance Single submitter
- BAG6 p.Leu635Ile Uncertain significance Single submitter
- BAG6 p.Leu94Val Uncertain significance Single submitter
- BAG6 p.Met355Val Uncertain significance Single submitter
- BAG6 p.Met580Leu Uncertain significance Single submitter
- BAG6 p.Pro115Ala Uncertain significance Single submitter
- BAG6 p.Pro115Thr Uncertain significance Single submitter
- BAG6 p.Pro224Ser Uncertain significance Single submitter
- BAG6 p.Pro242Ser Uncertain significance Single submitter
- BAG6 p.Pro390Ser Uncertain significance Single submitter
- BAG6 p.Pro397Ser Uncertain significance Single submitter
- BAG6 p.Pro435Leu Uncertain significance Single submitter
- BAG6 p.Pro472Leu Uncertain significance Single submitter
- BAG6 p.Pro547Ser Uncertain significance Single submitter
- BAG6 p.Pro963Arg Uncertain significance Single submitter
- BAG6 p.Ser1116Asn Uncertain significance Single submitter
- BAG6 p.Ser282Asn Uncertain significance Single submitter
- BAG6 p.Thr108Pro Uncertain significance Single submitter
- BAG6 p.Val448Met Uncertain significance Single submitter
- BAG6 p.Val987Asp Uncertain significance Single submitter
Predictors split 28
The independent predictors disagree with each other — read with care.
- BAG6 p.Arg1027Trp Uncertain significance Single submitter
- BAG6 p.Arg1099Trp Uncertain significance Single submitter
- BAG6 p.Arg1150Cys Uncertain significance Single submitter
- BAG6 p.Arg290His Uncertain significance Single submitter
- BAG6 p.Arg387Trp Uncertain significance Single submitter
- BAG6 p.Arg536Trp Uncertain significance Single submitter
- BAG6 p.Arg835Gln Uncertain significance Single submitter
- BAG6 p.Arg931His Uncertain significance Single submitter
- BAG6 p.Asn340Asp Uncertain significance Single submitter
- BAG6 p.Asn340Ser Uncertain significance Single submitter
- BAG6 p.Gln520Glu Uncertain significance Single submitter
- BAG6 p.Met1076Val Uncertain significance Single submitter
- BAG6 p.Met172Thr Uncertain significance Single submitter
- BAG6 p.Met37Thr Uncertain significance Single submitter
- BAG6 p.Met580Thr Uncertain significance Single submitter
- BAG6 p.Pro191Leu Uncertain significance Single submitter
- BAG6 p.Pro196Leu Uncertain significance Single submitter
- BAG6 p.Pro257Leu Uncertain significance Single submitter
- BAG6 p.Pro388His Uncertain significance Single submitter
- BAG6 p.Pro435Ala Uncertain significance Single submitter
- BAG6 p.Pro595Leu Uncertain significance Single submitter
- BAG6 p.Pro694Ser Uncertain significance Single submitter
- BAG6 p.Pro695Arg Uncertain significance Single submitter
- BAG6 p.Pro708Leu Uncertain significance Single submitter
- BAG6 p.Ser1134Cys Uncertain significance Single submitter
- BAG6 p.Ser1147Thr Uncertain significance Single submitter
- BAG6 p.Thr245Ile Uncertain significance Single submitter
- BAG6 p.Thr301Met Uncertain significance Single submitter
All BAG6 variants
Benign 4
- p.Glu2= Single submitter
- p.His83= Single submitter
- p.Pro435= Single submitter
- p.Thr1083= Single submitter
Likely benign 8
Uncertain significance 71
- p.Gln1137Glu Multiple submitters ⚠
- p.Ala1101Val Single submitter ⚠
- p.Ala261Val Single submitter ⚠
- p.Arg1027Trp Single submitter ⚠
- p.Arg1099Trp Single submitter ⚠
- p.Arg1107Gln Single submitter ⚠
- p.Arg1133Gln Single submitter ⚠
- p.Arg1150Cys Single submitter ⚠
- p.Arg1156Gln Single submitter ⚠
- p.Arg118Gln Single submitter ⚠
- p.Arg186Gln Single submitter ⚠
- p.Arg279Gln Single submitter ⚠
- p.Arg290Cys Single submitter ⚠
- p.Arg290His Single submitter ⚠
- p.Arg387Trp Single submitter ⚠
- p.Arg439Trp Single submitter ⚠
- p.Arg536Trp Single submitter ⚠
- p.Arg749Gln Single submitter ⚠
- p.Arg816Leu Single submitter ⚠
- p.Arg835Gln Single submitter ⚠
- p.Arg928Gln Single submitter ⚠
- p.Arg931His Single submitter ⚠
- p.Arg934His Single submitter ⚠
- p.Asn1153Ser Single submitter ⚠
- p.Asn340Asp Single submitter ⚠
- p.Asn340Ser Single submitter ⚠
- p.Asn413His Single submitter ⚠
- p.Asn564Ser Single submitter ⚠
- p.Gln1155Arg Single submitter ⚠
- p.Gln456Arg Single submitter ⚠
- p.Gln520Glu Single submitter ⚠
- p.Gly112Val Single submitter ⚠
- p.Gly144Ser Single submitter ⚠
- p.Ile52Val Single submitter ⚠
- p.Leu635Ile Single submitter ⚠
- p.Leu94Val Single submitter ⚠
- p.Met1076Val Single submitter ⚠
- p.Met172Thr Single submitter ⚠
- p.Met355Val Single submitter ⚠
- p.Met37Thr Single submitter ⚠
- p.Met580Leu Single submitter ⚠
- p.Met580Thr Single submitter ⚠
- p.Pro115Ala Single submitter ⚠
- p.Pro115Thr Single submitter ⚠
- p.Pro191Leu Single submitter ⚠
- p.Pro196Leu Single submitter ⚠
- p.Pro224Ser Single submitter ⚠
- p.Pro242Ser Single submitter ⚠
- p.Pro257Leu Single submitter ⚠
- p.Pro388His Single submitter ⚠
- p.Pro390Ser Single submitter ⚠
- p.Pro397Ser Single submitter ⚠
- p.Pro435Ala Single submitter ⚠
- p.Pro435Leu Single submitter ⚠
- p.Pro472Leu Single submitter ⚠
- p.Pro547Ser Single submitter ⚠
- p.Pro595Leu Single submitter ⚠
- p.Pro694Ser Single submitter ⚠
- p.Pro695Arg Single submitter ⚠
- p.Pro708Leu Single submitter ⚠
- p.Pro963Arg Single submitter ⚠
- p.Ser1116Asn Single submitter ⚠
- p.Ser1134Cys Single submitter ⚠
- p.Ser1147Thr Single submitter ⚠
- p.Ser282Asn Single submitter ⚠
- p.Thr108Pro Single submitter ⚠
- p.Thr245Ile Single submitter ⚠
- p.Thr301Met Single submitter ⚠
- p.Val448Met Single submitter ⚠
- p.Val987Asp Single submitter ⚠
- p.Arg1139Ter No assertion criteria periventricular nodular heterotopia