BAIAP2L1 — 94 ClinVar variants
All ClinVar germline BAIAP2L1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 78 flagged for review →
3 Benign · 5 Likely benign · 86 Uncertain significance
Full BAIAP2L1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 78
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 64
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- BAIAP2L1 p.Ala287Thr Uncertain significance Single submitter
- BAIAP2L1 p.Ala447Thr Uncertain significance Single submitter
- BAIAP2L1 p.Ala481Val Uncertain significance Single submitter
- BAIAP2L1 p.Arg151Gln Uncertain significance Single submitter
- BAIAP2L1 p.Arg170His Uncertain significance Single submitter
- BAIAP2L1 p.Arg224Gln Uncertain significance Single submitter
- BAIAP2L1 p.Arg291Gly Uncertain significance Single submitter
- BAIAP2L1 p.Arg328Gln Uncertain significance Single submitter
- BAIAP2L1 p.Asp275Asn Uncertain significance Single submitter
- BAIAP2L1 p.Asp384Asn Uncertain significance Single submitter
- BAIAP2L1 p.Asp384Glu Uncertain significance Single submitter
- BAIAP2L1 p.Asp450Asn Uncertain significance Single submitter
- BAIAP2L1 p.Asp450Glu Uncertain significance Single submitter
- BAIAP2L1 p.Gln123Arg Uncertain significance Single submitter
- BAIAP2L1 p.Gln148His Uncertain significance Single submitter
- BAIAP2L1 p.Glu244Lys Uncertain significance Single submitter
- BAIAP2L1 p.Glu373Lys Uncertain significance Single submitter
- BAIAP2L1 p.Glu428Lys Uncertain significance Single submitter
- BAIAP2L1 p.Glu470Lys Uncertain significance Single submitter
- BAIAP2L1 p.Glu70Gly Uncertain significance Single submitter
- BAIAP2L1 p.Glu7Asp Uncertain significance Single submitter
- BAIAP2L1 p.Gly256Arg Uncertain significance Single submitter
- BAIAP2L1 p.Gly488Glu Uncertain significance Single submitter
- BAIAP2L1 p.Gly64Val Uncertain significance Single submitter
- BAIAP2L1 p.His206Gln Uncertain significance Single submitter
- BAIAP2L1 p.His208Arg Uncertain significance Single submitter
- BAIAP2L1 p.His82Gln Uncertain significance Single submitter
- BAIAP2L1 p.Ile161Val Uncertain significance Single submitter
- BAIAP2L1 p.Leu11Phe Uncertain significance Single submitter
- BAIAP2L1 p.Lys106Arg Uncertain significance Single submitter
- BAIAP2L1 p.Lys183Arg Uncertain significance Single submitter
- BAIAP2L1 p.Lys238Asn Uncertain significance Single submitter
- BAIAP2L1 p.Lys279Glu Uncertain significance Single submitter
- BAIAP2L1 p.Lys356Asn Uncertain significance Single submitter
- BAIAP2L1 p.Lys57Arg Uncertain significance Single submitter
- BAIAP2L1 p.Met115Val Uncertain significance Single submitter
- BAIAP2L1 p.Met44Val Uncertain significance Single submitter
- BAIAP2L1 p.Phe203Ser Uncertain significance Single submitter
- BAIAP2L1 p.Pro282Arg Uncertain significance Single submitter
- BAIAP2L1 p.Pro286Ser Uncertain significance Single submitter
- BAIAP2L1 p.Pro288Ser Uncertain significance Single submitter
- BAIAP2L1 p.Pro309Ser Uncertain significance Single submitter
- BAIAP2L1 p.Pro483Leu Uncertain significance Single submitter
- BAIAP2L1 p.Ser172Thr Uncertain significance Single submitter
- BAIAP2L1 p.Ser281Pro Uncertain significance Single submitter
- BAIAP2L1 p.Ser295Gly Uncertain significance Single submitter
- BAIAP2L1 p.Ser360Gly Uncertain significance Single submitter
- BAIAP2L1 p.Ser455Leu Uncertain significance Single submitter
- BAIAP2L1 p.Thr166Ile Uncertain significance Single submitter
- BAIAP2L1 p.Thr248Asn Uncertain significance Single submitter
- BAIAP2L1 p.Thr252Ile Uncertain significance Single submitter
- BAIAP2L1 p.Thr306Met Uncertain significance Single submitter
- BAIAP2L1 p.Thr409Asn Uncertain significance Single submitter
- BAIAP2L1 p.Thr458Met Uncertain significance Single submitter
- BAIAP2L1 p.Thr480Pro Uncertain significance Single submitter
- BAIAP2L1 p.Thr502Met Uncertain significance Single submitter
- BAIAP2L1 p.Thr63Ser Uncertain significance Single submitter
- BAIAP2L1 p.Trp391Arg Uncertain significance Single submitter
- BAIAP2L1 p.Val164Met Uncertain significance Single submitter
- BAIAP2L1 p.Val254Met Uncertain significance Single submitter
- BAIAP2L1 p.Val385Met Uncertain significance Single submitter
- BAIAP2L1 p.Val424Met Uncertain significance Single submitter
- BAIAP2L1 p.Val432Ile Uncertain significance Single submitter
- BAIAP2L1 p.Val74Ile Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- BAIAP2L1 p.Ala333Val Uncertain significance Single submitter
- BAIAP2L1 p.Arg3Gln Uncertain significance Single submitter
- BAIAP2L1 p.Asn9Lys Uncertain significance Single submitter
- BAIAP2L1 p.Cys194Ser Uncertain significance Single submitter
- BAIAP2L1 p.Glu60Val Uncertain significance Single submitter
- BAIAP2L1 p.Ile510Thr Uncertain significance Single submitter
- BAIAP2L1 p.Ile76Arg Uncertain significance Single submitter
- BAIAP2L1 p.Lys375Asn Uncertain significance Single submitter
- BAIAP2L1 p.Pro262Leu Uncertain significance Single submitter
- BAIAP2L1 p.Pro436Arg Uncertain significance Single submitter
- BAIAP2L1 p.Pro436Gln Uncertain significance Single submitter
- BAIAP2L1 p.Pro436Thr Uncertain significance Single submitter
- BAIAP2L1 p.Ser386Cys Uncertain significance Single submitter
- BAIAP2L1 p.Thr368Met Uncertain significance Single submitter
All BAIAP2L1 variants
Benign 3
- c.487-10_487-9insA Single submitter
- c.487-14_487-13insATTA Single submitter
- c.487-6_487-3del Single submitter
Likely benign 5
- c.487-14_487-13insATTATTATTA Single submitter
- p.Ala449= Single submitter
- p.Asn205Ser Single submitter
- p.Asn268Ser Single submitter
- p.Ser487= Single submitter
Uncertain significance 86
- p.Ala287Thr Single submitter ⚠
- p.Ala333Val Single submitter ⚠
- p.Ala447Thr Single submitter ⚠
- p.Ala481Val Single submitter ⚠
- p.Arg151Gln Single submitter ⚠
- p.Arg170His Single submitter ⚠
- p.Arg224Gln Single submitter ⚠
- p.Arg28Gln Single submitter
- p.Arg291Gly Single submitter ⚠
- p.Arg328Gln Single submitter ⚠
- p.Arg3Gln Single submitter ⚠
- p.Asn503Ser Single submitter
- p.Asn9Lys Single submitter ⚠
- p.Asp275Asn Single submitter ⚠
- p.Asp376Asn Single submitter
- p.Asp384Asn Single submitter ⚠
- p.Asp384Glu Single submitter ⚠
- p.Asp450Asn Single submitter ⚠
- p.Asp450Glu Single submitter ⚠
- p.Cys194Ser Single submitter ⚠
- p.Gln123Arg Single submitter ⚠
- p.Gln148His Single submitter ⚠
- p.Gln171His Single submitter
- p.Glu244Lys Single submitter ⚠
- p.Glu373Lys Single submitter ⚠
- p.Glu428Lys Single submitter ⚠
- p.Glu470Lys Single submitter ⚠
- p.Glu60Val Single submitter ⚠
- p.Glu70Gly Single submitter ⚠
- p.Glu7Asp Single submitter ⚠
- p.Gly256Arg Single submitter ⚠
- p.Gly488Glu Single submitter ⚠
- p.Gly64Val Single submitter ⚠
- p.His206Gln Single submitter ⚠
- p.His208Arg Single submitter ⚠
- p.His350Tyr Single submitter
- p.His82Gln Single submitter ⚠
- p.Ile161Val Single submitter ⚠
- p.Ile510Thr Single submitter ⚠
- p.Ile76Arg Single submitter ⚠
- p.Leu11Phe Single submitter ⚠
- p.Leu486Arg Single submitter
- p.Lys106Arg Single submitter ⚠
- p.Lys183Arg Single submitter ⚠
- p.Lys238Asn Single submitter ⚠
- p.Lys279Glu Single submitter ⚠
- p.Lys356Asn Single submitter ⚠
- p.Lys375Asn Single submitter ⚠
- p.Lys57Arg Single submitter ⚠
- p.Met115Val Single submitter ⚠
- p.Met44Val Single submitter ⚠
- p.Phe203Ser Single submitter ⚠
- p.Pro262Leu Single submitter ⚠
- p.Pro282Arg Single submitter ⚠
- p.Pro286Ser Single submitter ⚠
- p.Pro288Ser Single submitter ⚠
- p.Pro309Ser Single submitter ⚠
- p.Pro436Arg Single submitter ⚠
- p.Pro436Gln Single submitter ⚠
- p.Pro436Thr Single submitter ⚠
- p.Pro483Leu Single submitter ⚠
- p.Ser172Thr Single submitter ⚠
- p.Ser281Pro Single submitter ⚠
- p.Ser295Gly Single submitter ⚠
- p.Ser329Leu Single submitter
- p.Ser360Gly Single submitter ⚠
- p.Ser386Cys Single submitter ⚠
- p.Ser455Leu Single submitter ⚠
- p.Thr166Ile Single submitter ⚠
- p.Thr248Asn Single submitter ⚠
- p.Thr252Ile Single submitter ⚠
- p.Thr306Met Single submitter ⚠
- p.Thr368Met Single submitter ⚠
- p.Thr397Met Single submitter
- p.Thr409Asn Single submitter ⚠
- p.Thr458Met Single submitter ⚠
- p.Thr480Pro Single submitter ⚠
- p.Thr502Met Single submitter ⚠
- p.Thr63Ser Single submitter ⚠
- p.Trp391Arg Single submitter ⚠
- p.Val164Met Single submitter ⚠
- p.Val254Met Single submitter ⚠
- p.Val385Met Single submitter ⚠
- p.Val424Met Single submitter ⚠
- p.Val432Ile Single submitter ⚠
- p.Val74Ile Single submitter ⚠