BANK1 — 137 ClinVar variants

All ClinVar germline BANK1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 125 flagged for review →

1 Conflicting · 1 Benign/Likely benign · 8 Likely benign · 127 Uncertain significance

Full BANK1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 125

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 1

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

BANK1 p.His762Tyr Conflicting Single submitter

Predictors lean, ClinVar uncertain 113

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 11

The independent predictors disagree with each other — read with care.

All BANK1 variants

Conflicting classifications of pathogenicity 1

p.His762Tyr Single submitter ⚠

Benign/Likely benign 1

p.Trp40Cys Multiple submitters systemic lupus erythematosus

Likely benign 8

p.Arg236Cys Single submitter
p.Gln334= Single submitter
p.Ile153Val Single submitter
p.Leu711= Single submitter
p.Phe162Leu Single submitter
p.Phe398= Single submitter
p.Thr26Ala Single submitter
p.Tyr759His Single submitter

Uncertain significance 127

p.Ala258Gly Single submitter ⚠
p.Ala273Val Single submitter ⚠
p.Ala351Glu Single submitter ⚠
p.Ala37Thr Single submitter ⚠
p.Ala383Val Single submitter ⚠
p.Ala447Val Single submitter ⚠
p.Ala581Pro Single submitter ⚠
p.Ala640Thr Single submitter ⚠
p.Ala769Val Single submitter ⚠
p.Arg515Gln Single submitter ⚠
p.Arg617Gln Single submitter ⚠
p.Arg61Cys Single submitter ⚠
p.Arg641Gly Single submitter ⚠
p.Arg660Leu Single submitter ⚠
p.Arg720Gln Single submitter ⚠
p.Arg720Leu Single submitter ⚠
p.Arg723Gln Single submitter ⚠
p.Arg91Thr Single submitter ⚠
p.Asn410Ser Single submitter ⚠
p.Asn64Ser Single submitter ⚠
p.Asn756Ser Single submitter ⚠
p.Asn765Ser Single submitter ⚠
p.Asp169Tyr Single submitter ⚠
p.Asp28Ala Single submitter ⚠
p.Asp28Val Single submitter ⚠
p.Asp495Ala Single submitter ⚠
p.Asp647Glu Single submitter ⚠
p.Cys18Gly Single submitter ⚠
p.Cys250Arg Single submitter ⚠
p.Cys250Ser Single submitter ⚠
p.Cys267Arg Single submitter ⚠
p.Cys300Phe Single submitter ⚠
p.Cys365Arg Single submitter ⚠
p.Glu255Val Single submitter ⚠
p.Glu287Asp Single submitter ⚠
p.Glu287Gln Single submitter ⚠
p.Glu378Asp Single submitter ⚠
p.Glu399Lys Single submitter ⚠
p.Glu411Lys Single submitter ⚠
p.Glu467Gly Single submitter ⚠
p.Glu553Lys Single submitter ⚠
p.Glu568Val Single submitter ⚠
p.Glu570Gly Single submitter ⚠
p.Glu570Lys Single submitter ⚠
p.Glu573Asp Single submitter ⚠
p.Glu626Asp Single submitter ⚠
p.Glu678Lys Single submitter ⚠
p.Glu679Asp Single submitter ⚠
p.Glu712Gln Single submitter ⚠
p.Gly19Cys Single submitter ⚠
p.Gly211Ser Single submitter ⚠
p.Gly367Arg Single submitter
p.Gly449Ala Single submitter ⚠
p.Gly463Ala Single submitter ⚠
p.Gly555Arg Single submitter ⚠
p.Gly747Arg Single submitter ⚠
p.Gly748Asp Single submitter ⚠
p.Gly9Arg Single submitter ⚠
p.His174Tyr Single submitter ⚠
p.His547Arg Single submitter ⚠
p.Ile137Phe Single submitter ⚠
p.Ile137Val Single submitter ⚠
p.Ile178Met Single submitter ⚠
p.Ile184Met Single submitter ⚠
p.Ile237Leu Single submitter ⚠
p.Ile270Thr Single submitter ⚠
p.Ile304Thr Single submitter ⚠
p.Ile314Val Single submitter ⚠
p.Ile319Thr Single submitter ⚠
p.Ile319Val Single submitter ⚠
p.Ile621Val Single submitter ⚠
p.Ile631Met Single submitter ⚠
p.Leu105Arg Single submitter ⚠
p.Leu10Arg Single submitter ⚠
p.Leu187Pro Single submitter ⚠
p.Leu355Phe Single submitter ⚠
p.Leu504His Single submitter ⚠
p.Leu58Pro Single submitter ⚠
p.Leu669Pro Single submitter ⚠
p.Leu673Val Single submitter ⚠
p.Lys109Gln Single submitter ⚠
p.Lys156Glu Single submitter ⚠
p.Lys276Asn Single submitter ⚠
p.Lys460Arg Single submitter ⚠
p.Lys569Arg Single submitter ⚠
p.Lys648Thr Single submitter ⚠
p.Lys757Thr Single submitter ⚠
p.Lys783Glu Single submitter ⚠
p.Lys96Glu Single submitter ⚠
p.Met251Val Single submitter ⚠
p.Met374Leu Single submitter ⚠
p.Phe528Val Single submitter ⚠
p.Phe777Cys Single submitter ⚠
p.Pro143Thr Single submitter ⚠
p.Pro15Ser Single submitter ⚠
p.Pro167Ser Single submitter ⚠
p.Pro23Gln Single submitter ⚠
p.Pro509Ser Single submitter ⚠
p.Pro513Ala Single submitter ⚠
p.Pro514fs Single submitter
p.Pro514Leu Single submitter ⚠
p.Pro558Ser Single submitter ⚠
p.Pro614Thr Single submitter ⚠
p.Ser12Asn Single submitter ⚠
p.Ser152Arg Single submitter ⚠
p.Ser152Asn Single submitter ⚠
p.Ser424Phe Single submitter ⚠
p.Ser429Tyr Single submitter ⚠
p.Ser479Asn Single submitter ⚠
p.Ser507Asn Single submitter ⚠
p.Ser663Arg Single submitter ⚠
p.Thr168Ala Single submitter ⚠
p.Thr345Ala Single submitter
p.Thr579Ile Single submitter ⚠
p.Thr627Ser Single submitter ⚠
p.Thr628Ile Single submitter ⚠
p.Thr76Met Single submitter ⚠
p.Trp135Arg Single submitter ⚠
p.Trp249Leu Single submitter ⚠
p.Tyr60His Single submitter ⚠
p.Val226Ile Single submitter ⚠
p.Val475Ala Single submitter ⚠
p.Val51Ala Single submitter ⚠
p.Val634Ala Single submitter ⚠
p.Val687Ile Single submitter ⚠
p.Val687Leu Single submitter ⚠
p.Arg61His No assertion criteria Variant of unknown significance ⚠