BARHL2 — 58 ClinVar variants
All ClinVar germline BARHL2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 54 flagged for review →
2 Likely benign · 56 Uncertain significance
Full BARHL2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 54
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 33
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- BARHL2 p.Ala131Ser Uncertain significance Single submitter
- BARHL2 p.Ala47Val Uncertain significance Single submitter
- BARHL2 p.Ala99Val Uncertain significance Single submitter
- BARHL2 p.Arg216Gln Uncertain significance Single submitter
- BARHL2 p.Arg216Trp Uncertain significance Single submitter
- BARHL2 p.Arg354Trp Uncertain significance Single submitter
- BARHL2 p.Arg359Cys Uncertain significance Single submitter
- BARHL2 p.Asp14Tyr Uncertain significance Single submitter
- BARHL2 p.Gln119Pro Uncertain significance Single submitter
- BARHL2 p.Gln173Arg Uncertain significance Single submitter
- BARHL2 p.Gln92Leu Uncertain significance Single submitter
- BARHL2 p.Glu180Gly Uncertain significance Single submitter
- BARHL2 p.Glu189Lys Uncertain significance Single submitter
- BARHL2 p.Glu54Asp Uncertain significance Single submitter
- BARHL2 p.His169Arg Uncertain significance Single submitter
- BARHL2 p.His179Gln Uncertain significance Single submitter
- BARHL2 p.His86Arg Uncertain significance Single submitter
- BARHL2 p.Leu376Ser Uncertain significance Single submitter
- BARHL2 p.Lys197Gln Uncertain significance Single submitter
- BARHL2 p.Met263Thr Uncertain significance Single submitter
- BARHL2 p.Met310Val Uncertain significance Single submitter
- BARHL2 p.Pro114Ser Uncertain significance Single submitter
- BARHL2 p.Pro171Ala Uncertain significance Single submitter
- BARHL2 p.Pro184Ala Uncertain significance Single submitter
- BARHL2 p.Pro184Ser Uncertain significance Single submitter
- BARHL2 p.Pro312Gln Uncertain significance Single submitter
- BARHL2 p.Pro367Leu Uncertain significance Single submitter
- BARHL2 p.Pro72Ser Uncertain significance Single submitter
- BARHL2 p.Ser18Ala Uncertain significance Single submitter
- BARHL2 p.Ser191Arg Uncertain significance Single submitter
- BARHL2 p.Ser320Thr Uncertain significance Single submitter
- BARHL2 p.Ser378Gly Uncertain significance Single submitter
- BARHL2 p.Thr219Met Uncertain significance Single submitter
Predictors split 21
The independent predictors disagree with each other — read with care.
- BARHL2 p.Ala332Val Uncertain significance Single submitter
- BARHL2 p.Ala334Thr Uncertain significance Single submitter
- BARHL2 p.Arg359His Uncertain significance Single submitter
- BARHL2 p.Gln111Arg Uncertain significance Single submitter
- BARHL2 p.Gln113Arg Uncertain significance Single submitter
- BARHL2 p.Glu223Lys Uncertain significance Single submitter
- BARHL2 p.Glu54Gln Uncertain significance Single submitter
- BARHL2 p.Gly364Ser Uncertain significance Single submitter
- BARHL2 p.Gly8Arg Uncertain significance Single submitter
- BARHL2 p.Ile362Phe Uncertain significance Single submitter
- BARHL2 p.Met337Ile Uncertain significance Single submitter
- BARHL2 p.Met3Ile Uncertain significance Single submitter
- BARHL2 p.Phe311Leu Uncertain significance Single submitter
- BARHL2 p.Pro122Ala Uncertain significance Single submitter
- BARHL2 p.Pro124Arg Uncertain significance Single submitter
- BARHL2 p.Pro124Ser Uncertain significance Single submitter
- BARHL2 p.Pro125Arg Uncertain significance Single submitter
- BARHL2 p.Pro358Ser Uncertain significance Single submitter
- BARHL2 p.Pro97Arg Uncertain significance Single submitter
- BARHL2 p.Ser220Arg Uncertain significance Single submitter
- BARHL2 p.Thr15Arg Uncertain significance Single submitter
All BARHL2 variants
Likely benign 2
- p.Leu115Pro Single submitter
- p.Pro34= No assertion criteria EBV-positive nodal T- and NK-cell lymphoma
Uncertain significance 56
- p.Ala131Ser Single submitter ⚠
- p.Ala332Val Single submitter ⚠
- p.Ala334Thr Single submitter ⚠
- p.Ala47Val Single submitter ⚠
- p.Ala99Val Single submitter ⚠
- p.Arg216Gln Single submitter ⚠
- p.Arg216Trp Single submitter ⚠
- p.Arg354Trp Single submitter ⚠
- p.Arg359Cys Single submitter ⚠
- p.Arg359His Single submitter ⚠
- p.Asp14Tyr Single submitter ⚠
- p.Gln111Arg Single submitter ⚠
- p.Gln113Arg Single submitter ⚠
- p.Gln119Pro Single submitter ⚠
- p.Gln173Arg Single submitter ⚠
- p.Gln92Leu Single submitter ⚠
- p.Glu180Gly Single submitter ⚠
- p.Glu189Lys Single submitter ⚠
- p.Glu223Lys Single submitter ⚠
- p.Glu54Asp Single submitter ⚠
- p.Glu54Gln Single submitter ⚠
- p.Gly364Ser Single submitter ⚠
- p.Gly5Arg Single submitter
- p.Gly8Arg Single submitter ⚠
- p.His169Arg Single submitter ⚠
- p.His179Gln Single submitter ⚠
- p.His86Arg Single submitter ⚠
- p.Ile362Phe Single submitter ⚠
- p.Leu376Ser Single submitter ⚠
- p.Lys197Gln Single submitter ⚠
- p.Met263Thr Single submitter ⚠
- p.Met310Val Single submitter ⚠
- p.Met337Ile Single submitter ⚠
- p.Met3Ile Single submitter ⚠
- p.Phe311Leu Single submitter ⚠
- p.Pro114Ser Single submitter ⚠
- p.Pro122Ala Single submitter ⚠
- p.Pro124Arg Single submitter ⚠
- p.Pro124Ser Single submitter ⚠
- p.Pro125Arg Single submitter ⚠
- p.Pro171Ala Single submitter ⚠
- p.Pro184Ala Single submitter ⚠
- p.Pro184Ser Single submitter ⚠
- p.Pro312Gln Single submitter ⚠
- p.Pro358Ser Single submitter ⚠
- p.Pro367Leu Single submitter ⚠
- p.Pro51Leu Single submitter
- p.Pro72Ser Single submitter ⚠
- p.Pro97Arg Single submitter ⚠
- p.Ser18Ala Single submitter ⚠
- p.Ser191Arg Single submitter ⚠
- p.Ser220Arg Single submitter ⚠
- p.Ser320Thr Single submitter ⚠
- p.Ser378Gly Single submitter ⚠
- p.Thr15Arg Single submitter ⚠
- p.Thr219Met Single submitter ⚠