BARX2 — 40 ClinVar variants
All ClinVar germline BARX2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 35 flagged for review →
2 Benign · 2 Likely benign · 36 Uncertain significance
Full BARX2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 35
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 29
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- BARX2 p.Arg129Gln Uncertain significance Single submitter
- BARX2 p.Arg184His Uncertain significance Single submitter
- BARX2 p.Arg68Gln Uncertain significance Single submitter
- BARX2 p.Arg68Trp Uncertain significance Single submitter
- BARX2 p.Asn225His Uncertain significance Single submitter
- BARX2 p.Gln266Arg Uncertain significance Single submitter
- BARX2 p.Glu114Asp Uncertain significance Single submitter
- BARX2 p.Glu114Lys Uncertain significance Single submitter
- BARX2 p.Glu142Lys Uncertain significance Single submitter
- BARX2 p.Glu274Gly Uncertain significance Single submitter
- BARX2 p.His85Tyr Uncertain significance Single submitter
- BARX2 p.Ile139Val Uncertain significance Single submitter
- BARX2 p.Leu116Pro Uncertain significance Single submitter
- BARX2 p.Leu143Met Uncertain significance Single submitter
- BARX2 p.Leu97Arg Uncertain significance Single submitter
- BARX2 p.Lys131Asn Uncertain significance Single submitter
- BARX2 p.Met224Arg Uncertain significance Single submitter
- BARX2 p.Pro161Leu Uncertain significance Single submitter
- BARX2 p.Pro203Leu Uncertain significance Single submitter
- BARX2 p.Pro236Ser Uncertain significance Single submitter
- BARX2 p.Pro249Leu Uncertain significance Single submitter
- BARX2 p.Pro271Arg Uncertain significance Single submitter
- BARX2 p.Pro88Ala Uncertain significance Single submitter
- BARX2 p.Pro91Leu Uncertain significance Single submitter
- BARX2 p.Ser119Thr Uncertain significance Single submitter
- BARX2 p.Ser84Pro Uncertain significance Single submitter
- BARX2 p.Thr160Ser Uncertain significance Single submitter
- BARX2 p.Thr35Asn Uncertain significance Single submitter
- BARX2 p.Thr90Ser Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- BARX2 p.Arg135Trp Uncertain significance Single submitter
- BARX2 p.Arg19Gly Uncertain significance Single submitter
- BARX2 p.Cys3Tyr Uncertain significance Single submitter
- BARX2 p.Ile218Thr Uncertain significance Single submitter
- BARX2 p.Lys23Glu Uncertain significance Single submitter
- BARX2 p.Tyr22Cys Uncertain significance Single submitter
All BARX2 variants
Benign 2
- p.Arg252His Multiple submitters
- p.Gln155= Single submitter
Likely benign 2
- p.Ile270Val Single submitter
- p.Ser273Leu Single submitter
Uncertain significance 36
- p.Arg129Gln Single submitter ⚠
- p.Arg135Trp Single submitter ⚠
- p.Arg184His Single submitter ⚠
- p.Arg19Gly Single submitter ⚠
- p.Arg68Gln Single submitter ⚠
- p.Arg68Trp Single submitter ⚠
- p.Arg8Thr Single submitter
- p.Asn225His Single submitter ⚠
- p.Cys3Tyr Single submitter ⚠
- p.Gln266Arg Single submitter ⚠
- p.Glu114Asp Single submitter ⚠
- p.Glu114Lys Single submitter ⚠
- p.Glu142Lys Single submitter ⚠
- p.Glu274Gly Single submitter ⚠
- p.His85Tyr Single submitter ⚠
- p.Ile139Val Single submitter ⚠
- p.Ile218Thr Single submitter ⚠
- p.Leu116Pro Single submitter ⚠
- p.Leu143Met Single submitter ⚠
- p.Leu97Arg Single submitter ⚠
- p.Lys131Asn Single submitter ⚠
- p.Lys23Glu Single submitter ⚠
- p.Met224Arg Single submitter ⚠
- p.Pro161Leu Single submitter ⚠
- p.Pro203Leu Single submitter ⚠
- p.Pro236Ser Single submitter ⚠
- p.Pro249Leu Single submitter ⚠
- p.Pro271Arg Single submitter ⚠
- p.Pro88Ala Single submitter ⚠
- p.Pro91Leu Single submitter ⚠
- p.Ser119Thr Single submitter ⚠
- p.Ser84Pro Single submitter ⚠
- p.Thr160Ser Single submitter ⚠
- p.Thr35Asn Single submitter ⚠
- p.Thr90Ser Single submitter ⚠
- p.Tyr22Cys Single submitter ⚠