BCAN — 144 ClinVar variants
All ClinVar germline BCAN variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 135 flagged for review →
3 Benign · 9 Likely benign · 132 Uncertain significance
Full BCAN gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 135
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 77
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- BCAN p.Ala10Pro Uncertain significance Single submitter
- BCAN p.Ala169Thr Uncertain significance Single submitter
- BCAN p.Ala357Thr Uncertain significance Single submitter
- BCAN p.Ala357Val Uncertain significance Single submitter
- BCAN p.Ala361Thr Uncertain significance Single submitter
- BCAN p.Ala43Thr Uncertain significance Single submitter
- BCAN p.Ala481Glu Uncertain significance Single submitter
- BCAN p.Ala509Val Uncertain significance Single submitter
- BCAN p.Ala513Val Uncertain significance Single submitter
- BCAN p.Ala562Ser Uncertain significance Single submitter
- BCAN p.Ala591Thr Uncertain significance Single submitter
- BCAN p.Ala609Thr Uncertain significance Single submitter
- BCAN p.Ala646Pro Uncertain significance Single submitter
- BCAN p.Arg167His Uncertain significance Single submitter
- BCAN p.Arg167Leu Uncertain significance Single submitter
- BCAN p.Arg181Gly Uncertain significance Single submitter
- BCAN p.Arg321His Uncertain significance Single submitter
- BCAN p.Arg33Ser Uncertain significance Single submitter
- BCAN p.Arg402His Uncertain significance Single submitter
- BCAN p.Arg599Gln Uncertain significance Single submitter
- BCAN p.Arg669His Uncertain significance Single submitter
- BCAN p.Arg750Gly Uncertain significance Single submitter
- BCAN p.Arg841Ser Uncertain significance Single submitter
- BCAN p.Arg843Gln Uncertain significance Single submitter
- BCAN p.Arg863His Uncertain significance Single submitter
- BCAN p.Arg878Gln Uncertain significance Single submitter
- BCAN p.Asp32Gly Uncertain significance Single submitter
- BCAN p.Asp375Asn Uncertain significance Single submitter
- BCAN p.Asp375His Uncertain significance Single submitter
- BCAN p.Asp749Asn Uncertain significance Single submitter
- BCAN p.Asp791Asn Uncertain significance Single submitter
- BCAN p.Asp885His Uncertain significance Single submitter
- BCAN p.Cys137Phe Uncertain significance Single submitter
- BCAN p.Cys655Tyr Uncertain significance Single submitter
- BCAN p.Cys844Phe Uncertain significance Single submitter
- BCAN p.Gln46Arg Uncertain significance Single submitter
- BCAN p.Gln825Arg Uncertain significance Single submitter
- BCAN p.Glu422Gly Uncertain significance Single submitter
- BCAN p.Glu87Gly Uncertain significance Single submitter
- BCAN p.Glu884Gln Uncertain significance Single submitter
- BCAN p.Gly226Arg Uncertain significance Single submitter
- BCAN p.Gly415Arg Uncertain significance Single submitter
- BCAN p.Gly525Arg Uncertain significance Single submitter
- BCAN p.Gly525Glu Uncertain significance Single submitter
- BCAN p.Gly566Glu Uncertain significance Single submitter
- BCAN p.Gly571Ser Uncertain significance Single submitter
- BCAN p.Gly616Glu Uncertain significance Single submitter
- BCAN p.Gly684Asp Uncertain significance Single submitter
- BCAN p.Gly684Val Uncertain significance Single submitter
- BCAN p.His300Gln Uncertain significance Single submitter
- BCAN p.His881Gln Uncertain significance Single submitter
- BCAN p.Ile134Val Uncertain significance Single submitter
- BCAN p.Ile380Val Uncertain significance Single submitter
- BCAN p.Leu387Val Uncertain significance Single submitter
- BCAN p.Lys451Asn Uncertain significance Single submitter
- BCAN p.Lys458Glu Uncertain significance Single submitter
- BCAN p.Met787Thr Uncertain significance Single submitter
- BCAN p.Pro129Ser Uncertain significance Single submitter
- BCAN p.Pro242Leu Uncertain significance Single submitter
- BCAN p.Pro578Ser Uncertain significance Single submitter
- BCAN p.Pro629Thr Uncertain significance Single submitter
- BCAN p.Pro7Ser Uncertain significance Single submitter
- BCAN p.Pro830Arg Uncertain significance Single submitter
- BCAN p.Pro876Arg Uncertain significance Single submitter
- BCAN p.Ser488Thr Uncertain significance Single submitter
- BCAN p.Ser575Pro Uncertain significance Single submitter
- BCAN p.Ser727Arg Uncertain significance Single submitter
- BCAN p.Thr384Arg Uncertain significance Single submitter
- BCAN p.Thr386Ala Uncertain significance Single submitter
- BCAN p.Thr420Ala Uncertain significance Single submitter
- BCAN p.Thr430Ala Uncertain significance Single submitter
- BCAN p.Thr497Ser Uncertain significance Single submitter
- BCAN p.Thr585Ala Uncertain significance Single submitter
- BCAN p.Tyr196Asn Uncertain significance Single submitter
- BCAN p.Tyr351His Uncertain significance Single submitter
- BCAN p.Val625Leu Uncertain significance Single submitter
- BCAN p.Val762Ile Uncertain significance Single submitter
Predictors split 58
The independent predictors disagree with each other — read with care.
- BCAN p.Arg105Gly Benign Multiple submitters
- BCAN p.Ala112Thr Uncertain significance Single submitter
- BCAN p.Ala166Val Uncertain significance Single submitter
- BCAN p.Ala2Thr Uncertain significance Single submitter
- BCAN p.Ala373Ser Uncertain significance Single submitter
- BCAN p.Ala698Thr Uncertain significance Single submitter
- BCAN p.Arg181Cys Uncertain significance Single submitter
- BCAN p.Arg347His Uncertain significance Single submitter
- BCAN p.Arg36Cys Uncertain significance Single submitter
- BCAN p.Arg402Cys Uncertain significance Single submitter
- BCAN p.Arg599Trp Uncertain significance Single submitter
- BCAN p.Arg669Cys Uncertain significance Single submitter
- BCAN p.Arg833Cys Uncertain significance Single submitter
- BCAN p.Arg833His Uncertain significance Single submitter
- BCAN p.Arg863Cys Uncertain significance Single submitter
- BCAN p.Arg86Trp Uncertain significance Single submitter
- BCAN p.Arg97His Uncertain significance Single submitter
- BCAN p.Asn130Lys Uncertain significance Single submitter
- BCAN p.Asp679His Uncertain significance Single submitter
- BCAN p.Glu102Gln Uncertain significance Single submitter
- BCAN p.Glu467Lys Uncertain significance Single submitter
- BCAN p.Glu473Val Uncertain significance Single submitter
- BCAN p.Glu475Asp Uncertain significance Single submitter
- BCAN p.Glu485Lys Uncertain significance Single submitter
- BCAN p.Glu526Lys Uncertain significance Single submitter
- BCAN p.Glu589Lys Uncertain significance Single submitter
- BCAN p.Glu711Lys Uncertain significance Single submitter
- BCAN p.Glu860Lys Uncertain significance Single submitter
- BCAN p.Glu865Gly Uncertain significance Single submitter
- BCAN p.Gly142Ser Uncertain significance Single submitter
- BCAN p.Gly677Glu Uncertain significance Single submitter
- BCAN p.Gly828Ser Uncertain significance Single submitter
- BCAN p.Gly847Arg Uncertain significance Single submitter
- BCAN p.Gly862Ser Uncertain significance Single submitter
- BCAN p.Gly95Glu Uncertain significance Single submitter
- BCAN p.Ile726Val Uncertain significance Single submitter
- BCAN p.Leu486Phe Likely benign Single submitter
- BCAN p.Leu595Ile Benign Single submitter
- BCAN p.Leu840Phe Uncertain significance Single submitter
- BCAN p.Pro578Arg Uncertain significance Single submitter
- BCAN p.Pro654Leu Uncertain significance Single submitter
- BCAN p.Pro690Ser Uncertain significance Single submitter
- BCAN p.Pro817Leu Uncertain significance Single submitter
- BCAN p.Pro819Leu Uncertain significance Single submitter
- BCAN p.Ser366Ala Uncertain significance Single submitter
- BCAN p.Ser418Asn Uncertain significance Single submitter
- BCAN p.Ser593Phe Uncertain significance Single submitter
- BCAN p.Ser905Phe Uncertain significance Single submitter
- BCAN p.Thr287Ala Uncertain significance Single submitter
- BCAN p.Thr382Lys Uncertain significance Single submitter
- BCAN p.Thr430Met Uncertain significance Single submitter
- BCAN p.Thr598Ile Uncertain significance Single submitter
- BCAN p.Tyr225His Uncertain significance Single submitter
- BCAN p.Val381Phe Uncertain significance Single submitter
- BCAN p.Val643Met Uncertain significance Single submitter
- BCAN p.Val798Met Uncertain significance Single submitter
- BCAN p.Val836Leu Uncertain significance Single submitter
- BCAN p.Val839Leu Uncertain significance Single submitter
All BCAN variants
Benign 3
- p.Arg105Gly Multiple submitters ⚠
- p.Leu595Ile Single submitter ⚠
- p.Val651= Single submitter
Likely benign 9
- p.Ala899Thr Single submitter
- p.Arg706Leu Single submitter
- p.Arg896His Single submitter
- p.Leu486Phe Single submitter ⚠
- p.Leu515= Single submitter
- p.Pro232= Single submitter
- p.Pro489Leu Single submitter
- p.Tyr459= Single submitter
- p.Val24Ala Single submitter
Uncertain significance 132
- p.Ala10Pro Single submitter ⚠
- p.Ala112Thr Single submitter ⚠
- p.Ala166Val Single submitter ⚠
- p.Ala169Thr Single submitter ⚠
- p.Ala2Thr Single submitter ⚠
- p.Ala357Thr Single submitter ⚠
- p.Ala357Val Single submitter ⚠
- p.Ala361Thr Single submitter ⚠
- p.Ala373Ser Single submitter ⚠
- p.Ala43Thr Single submitter ⚠
- p.Ala481Glu Single submitter ⚠
- p.Ala509Val Single submitter ⚠
- p.Ala513Val Single submitter ⚠
- p.Ala562Ser Single submitter ⚠
- p.Ala591Thr Single submitter ⚠
- p.Ala609Thr Single submitter ⚠
- p.Ala646Pro Single submitter ⚠
- p.Ala698Thr Single submitter ⚠
- p.Arg167His Single submitter ⚠
- p.Arg167Leu Single submitter ⚠
- p.Arg181Cys Single submitter ⚠
- p.Arg181Gly Single submitter ⚠
- p.Arg321His Single submitter ⚠
- p.Arg33Ser Single submitter ⚠
- p.Arg347His Single submitter ⚠
- p.Arg36Cys Single submitter ⚠
- p.Arg402Cys Single submitter ⚠
- p.Arg402His Single submitter ⚠
- p.Arg599Gln Single submitter ⚠
- p.Arg599Trp Single submitter ⚠
- p.Arg669Cys Single submitter ⚠
- p.Arg669His Single submitter ⚠
- p.Arg750Gly Single submitter ⚠
- p.Arg833Cys Single submitter ⚠
- p.Arg833His Single submitter ⚠
- p.Arg841Ser Single submitter ⚠
- p.Arg843Gln Single submitter ⚠
- p.Arg863Cys Single submitter ⚠
- p.Arg863His Single submitter ⚠
- p.Arg86Trp Single submitter ⚠
- p.Arg878Gln Single submitter ⚠
- p.Arg97His Single submitter ⚠
- p.Asn130Lys Single submitter ⚠
- p.Asp32Gly Single submitter ⚠
- p.Asp375Asn Single submitter ⚠
- p.Asp375His Single submitter ⚠
- p.Asp679His Single submitter ⚠
- p.Asp749Asn Single submitter ⚠
- p.Asp791Asn Single submitter ⚠
- p.Asp885His Single submitter ⚠
- p.Cys137Phe Single submitter ⚠
- p.Cys655Tyr Single submitter ⚠
- p.Cys844Phe Single submitter ⚠
- p.Gln46Arg Single submitter ⚠
- p.Gln825Arg Single submitter ⚠
- p.Glu102Gln Single submitter ⚠
- p.Glu422Gly Single submitter ⚠
- p.Glu467Lys Single submitter ⚠
- p.Glu473Val Single submitter ⚠
- p.Glu475Asp Single submitter ⚠
- p.Glu485Lys Single submitter ⚠
- p.Glu526Lys Single submitter ⚠
- p.Glu589Lys Single submitter ⚠
- p.Glu711Lys Single submitter ⚠
- p.Glu860Lys Single submitter ⚠
- p.Glu865Gly Single submitter ⚠
- p.Glu87Gly Single submitter ⚠
- p.Glu884Gln Single submitter ⚠
- p.Gly142Ser Single submitter ⚠
- p.Gly226Arg Single submitter ⚠
- p.Gly415Arg Single submitter ⚠
- p.Gly525Arg Single submitter ⚠
- p.Gly525Glu Single submitter ⚠
- p.Gly566Glu Single submitter ⚠
- p.Gly571Ser Single submitter ⚠
- p.Gly616Glu Single submitter ⚠
- p.Gly677Glu Single submitter ⚠
- p.Gly684Asp Single submitter ⚠
- p.Gly684Val Single submitter ⚠
- p.Gly828Ser Single submitter ⚠
- p.Gly847Arg Single submitter ⚠
- p.Gly862Ser Single submitter ⚠
- p.Gly95Glu Single submitter ⚠
- p.His300Gln Single submitter ⚠
- p.His881Gln Single submitter ⚠
- p.Ile134Val Single submitter ⚠
- p.Ile380Val Single submitter ⚠
- p.Ile726Val Single submitter ⚠
- p.Leu387Val Single submitter ⚠
- p.Leu840Phe Single submitter ⚠
- p.Lys451Asn Single submitter ⚠
- p.Lys458Glu Single submitter ⚠
- p.Met787Thr Single submitter ⚠
- p.Pro129Ser Single submitter ⚠
- p.Pro242Leu Single submitter ⚠
- p.Pro578Arg Single submitter ⚠
- p.Pro578Ser Single submitter ⚠
- p.Pro629Thr Single submitter ⚠
- p.Pro654Leu Single submitter ⚠
- p.Pro690Ser Single submitter ⚠
- p.Pro7Ser Single submitter ⚠
- p.Pro817Leu Single submitter ⚠
- p.Pro819Leu Single submitter ⚠
- p.Pro830Arg Single submitter ⚠
- p.Pro876Arg Single submitter ⚠
- p.Ser366Ala Single submitter ⚠
- p.Ser418Asn Single submitter ⚠
- p.Ser488Thr Single submitter ⚠
- p.Ser575Pro Single submitter ⚠
- p.Ser593Phe Single submitter ⚠
- p.Ser727Arg Single submitter ⚠
- p.Ser905Phe Single submitter ⚠
- p.Thr287Ala Single submitter ⚠
- p.Thr382Lys Single submitter ⚠
- p.Thr384Arg Single submitter ⚠
- p.Thr386Ala Single submitter ⚠
- p.Thr420Ala Single submitter ⚠
- p.Thr430Ala Single submitter ⚠
- p.Thr430Met Single submitter ⚠
- p.Thr497Ser Single submitter ⚠
- p.Thr585Ala Single submitter ⚠
- p.Thr598Ile Single submitter ⚠
- p.Tyr196Asn Single submitter ⚠
- p.Tyr225His Single submitter ⚠
- p.Tyr351His Single submitter ⚠
- p.Val381Phe Single submitter ⚠
- p.Val625Leu Single submitter ⚠
- p.Val643Met Single submitter ⚠
- p.Val762Ile Single submitter ⚠
- p.Val798Met Single submitter ⚠
- p.Val836Leu Single submitter ⚠
- p.Val839Leu Single submitter ⚠