BCAR1 — 239 ClinVar variants

All ClinVar germline BCAR1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 215 flagged for review →

1 Likely pathogenic · 1 Conflicting · 12 Benign · 1 Benign/Likely benign · 13 Likely benign · 211 Uncertain significance

Full BCAR1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 215

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 102

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 113

The independent predictors disagree with each other — read with care.

All BCAR1 variants

Likely pathogenic 1

c.12+2T>C Single submitter hereditary breast ovarian cancer syndrome

Conflicting classifications of pathogenicity 1

p.Glu452Asp Single submitter ⚠

Benign 12

p.Ala411= Multiple submitters
p.Ala514= Multiple submitters
p.Ala590Thr Multiple submitters ⚠
p.Arg491Leu Multiple submitters
p.Gly450Val Multiple submitters
p.Gly568Ser Multiple submitters
p.His558Arg Multiple submitters
p.Pro356= Multiple submitters
p.Thr473= Multiple submitters
p.Val405= Multiple submitters
p.Lys693Arg Single submitter
p.Pro356Leu Single submitter

Benign/Likely benign 1

c.2100+10C>T Multiple submitters

Likely benign 13

c.66+3450C>G Single submitter
p.Ala472Thr Single submitter
p.Ala612Val Single submitter
p.Ala768= Single submitter
p.Arg607Gln Single submitter
p.Asn301Ser Single submitter
p.His552Tyr Single submitter ⚠
p.Leu504= Single submitter
p.Phe339= Single submitter
p.Pro365= Single submitter
p.Ser407Asn Single submitter ⚠
p.Thr152Ala Single submitter
p.Thr269= Single submitter

Uncertain significance 211

p.Ala227Thr Single submitter ⚠
p.Ala242Pro Single submitter ⚠
p.Ala304Thr Single submitter ⚠
p.Ala334Thr Single submitter ⚠
p.Ala336Val Single submitter ⚠
p.Ala349Pro Single submitter ⚠
p.Ala400Gly Single submitter ⚠
p.Ala400Thr Single submitter ⚠
p.Ala400Val Single submitter ⚠
p.Ala420Val Single submitter ⚠
p.Ala484Thr Single submitter ⚠
p.Ala486Val Single submitter ⚠
p.Ala510Thr Single submitter ⚠
p.Ala525Val Single submitter ⚠
p.Ala529Val Single submitter ⚠
p.Ala530Gly Single submitter ⚠
p.Ala530Thr Single submitter ⚠
p.Ala725Ser Single submitter ⚠
p.Ala72Gly Single submitter ⚠
p.Ala753Val Single submitter ⚠
p.Ala768Thr Single submitter ⚠
p.Ala770Val Single submitter ⚠
p.Ala828Ser Single submitter ⚠
p.Ala842Thr Single submitter ⚠
p.Ala870Thr Single submitter ⚠
p.Arg217Cys Single submitter ⚠
p.Arg217His Single submitter ⚠
p.Arg255Gln Single submitter ⚠
p.Arg280Gly Single submitter ⚠
p.Arg323His Single submitter ⚠
p.Arg343Cys Single submitter ⚠
p.Arg379Gln Single submitter ⚠
p.Arg391His Single submitter ⚠
p.Arg393Gln Single submitter ⚠
p.Arg393Trp Single submitter ⚠
p.Arg436Cys Single submitter ⚠
p.Arg436Leu Single submitter ⚠
p.Arg451Gln Single submitter ⚠
p.Arg523His Single submitter ⚠
p.Arg535His Single submitter ⚠
p.Arg543Trp Single submitter ⚠
p.Arg566Gln Single submitter ⚠
p.Arg566Trp Single submitter ⚠
p.Arg578Gln Single submitter ⚠
p.Arg606Lys Single submitter ⚠
p.Arg690Gln Single submitter ⚠
p.Arg690Trp Single submitter ⚠
p.Arg706Gln Single submitter ⚠
p.Arg713Trp Single submitter ⚠
p.Arg732Leu Single submitter ⚠
p.Arg824His Single submitter ⚠
p.Arg861His Single submitter ⚠
p.Arg862Cys Single submitter ⚠
p.Asn600Ser Single submitter ⚠
p.Asn754Ser Single submitter ⚠
p.Asn817Lys Single submitter ⚠
p.Asn817Ser Single submitter ⚠
p.Asp112Gly Single submitter ⚠
p.Asp199Gly Single submitter ⚠
p.Asp328Ala Single submitter ⚠
p.Asp328His Single submitter ⚠
p.Asp354Asn Single submitter ⚠
p.Asp373Ala Single submitter ⚠
p.Asp388Asn Single submitter ⚠
p.Asp388Tyr Single submitter ⚠
p.Asp401Tyr Single submitter ⚠
p.Asp401Val Single submitter ⚠
p.Asp406Asn Single submitter ⚠
p.Asp406His Single submitter ⚠
p.Asp41Tyr Single submitter ⚠
p.Asp503Val Single submitter ⚠
p.Asp627Tyr Single submitter ⚠
p.Asp650Gly Single submitter ⚠
p.Asp650Tyr Single submitter ⚠
p.Asp650Val Single submitter ⚠
p.Gln129Arg Single submitter ⚠
p.Gln138Arg Single submitter ⚠
p.Gln166His Single submitter ⚠
p.Gln546His Single submitter ⚠
p.Gln560Glu Single submitter ⚠
p.Gln699Glu Single submitter ⚠
p.Gln703Arg Single submitter ⚠
p.Gln726Glu Single submitter ⚠
p.Gln844Arg Single submitter ⚠
p.Glu225Ala Single submitter ⚠
p.Glu225Lys Single submitter ⚠
p.Glu233Lys Single submitter ⚠
p.Glu423Ala Single submitter ⚠
p.Glu549Gln Single submitter ⚠
p.Glu654Lys Single submitter ⚠
p.Glu657Asp Single submitter ⚠
p.Glu697Ala Single submitter ⚠
p.Gly186Arg Single submitter ⚠
p.Gly221Val Single submitter ⚠
p.Gly276Asp Single submitter ⚠
p.Gly276Cys Single submitter ⚠
p.Gly279Ser Single submitter ⚠
p.Gly27Ser Single submitter ⚠
p.Gly377Val Single submitter ⚠
p.Gly384Asp Single submitter ⚠
p.Gly469Asp Single submitter ⚠
p.Gly482Cys Single submitter ⚠
p.Gly482Ser Single submitter ⚠
p.Gly485Ser Single submitter ⚠
p.Gly559Ser Single submitter ⚠
p.Gly568Asp Single submitter ⚠
p.Gly599Ser Single submitter ⚠
p.Gly658Arg Single submitter ⚠
p.Gly659Ala Single submitter ⚠
p.Gly737Trp Single submitter ⚠
p.Gly77Ser Single submitter ⚠
p.His598Tyr Single submitter ⚠
p.Ile178Phe Single submitter ⚠
p.Ile236Thr Single submitter ⚠
p.Ile248Phe Single submitter ⚠
p.Leu241Val Single submitter ⚠
p.Leu321Val Single submitter ⚠
p.Leu346Val Single submitter ⚠
p.Leu395Val Single submitter ⚠
p.Leu500Met Single submitter ⚠
p.Leu562Phe Single submitter ⚠
p.Leu562Pro Single submitter ⚠
p.Leu573Phe Single submitter ⚠
p.Leu579Met Single submitter ⚠
p.Leu682Pro Single submitter ⚠
p.Leu683Gln Single submitter ⚠
p.Leu799Val Single submitter ⚠
p.Lys295Glu Single submitter ⚠
p.Lys337Gln Single submitter ⚠
p.Lys61Arg Single submitter ⚠
p.Lys702Arg Single submitter ⚠
p.Lys70Gln Single submitter ⚠
p.Lys776Arg Single submitter ⚠
p.Met198Ile Single submitter ⚠
p.Phe137Val Single submitter ⚠
p.Phe333Leu Single submitter ⚠
p.Pro109Arg Single submitter ⚠
p.Pro131Leu Single submitter ⚠
p.Pro140Thr Single submitter ⚠
p.Pro141Ser Single submitter ⚠
p.Pro153His Single submitter ⚠
p.Pro153Leu Single submitter ⚠
p.Pro160Leu Single submitter ⚠
p.Pro169Arg Single submitter ⚠
p.Pro169Ser Single submitter ⚠
p.Pro174Leu Single submitter ⚠
p.Pro195Ser Single submitter ⚠
p.Pro196Leu Single submitter ⚠
p.Pro243Arg Single submitter ⚠
p.Pro282Ala Single submitter ⚠
p.Pro282Leu Single submitter ⚠
p.Pro290Leu Single submitter ⚠
p.Pro298Ser Single submitter ⚠
p.Pro299Ser Single submitter ⚠
p.Pro317Ser Single submitter ⚠
p.Pro330Ser Single submitter ⚠
p.Pro338Ser Single submitter ⚠
p.Pro357Leu Single submitter ⚠
p.Pro365Leu Single submitter ⚠
p.Pro367Gln Single submitter ⚠
p.Pro375Ser Single submitter ⚠
p.Pro383Leu Single submitter ⚠
p.Pro415Arg Single submitter ⚠
p.Pro493His Single submitter ⚠
p.Pro499Leu Single submitter ⚠
p.Pro613Thr Single submitter ⚠
p.Pro649Leu Single submitter ⚠
p.Pro727Ala Single submitter ⚠
p.Pro730Leu Single submitter ⚠
p.Pro738Leu Single submitter ⚠
p.Pro79His Single submitter ⚠
p.Pro85Ser Single submitter ⚠
p.Pro95Leu Single submitter ⚠
p.Ser139Cys Single submitter ⚠
p.Ser139Phe Single submitter ⚠
p.Ser202Gly Single submitter ⚠
p.Ser23Thr Single submitter ⚠
p.Ser260Arg Single submitter ⚠
p.Ser292Thr Single submitter ⚠
p.Ser428Leu Single submitter ⚠
p.Ser438Arg Single submitter ⚠
p.Ser524Arg Single submitter ⚠
p.Ser524Asn Single submitter ⚠
p.Ser648Leu Single submitter ⚠
p.Ser694Asn Single submitter ⚠
p.Ser739Leu Single submitter ⚠
p.Ser810Asn Single submitter ⚠
p.Ser839Thr Single submitter ⚠
p.Thr100Met Single submitter ⚠
p.Thr200Ile Single submitter ⚠
p.Thr206Met Single submitter ⚠
p.Thr31Met Single submitter ⚠
p.Thr554Met Single submitter ⚠
p.Thr723Met Single submitter ⚠
p.Thr81Pro Single submitter ⚠
p.Thr829Ala Single submitter ⚠
p.Trp203Cys Single submitter ⚠
p.Trp660Cys Single submitter ⚠
p.Trp722Arg Single submitter ⚠
p.Tyr128Asn Single submitter ⚠
p.Tyr222Asp Single submitter ⚠
p.Val214Leu Single submitter ⚠
p.Val308Ile Single submitter ⚠
p.Val308Leu Single submitter ⚠
p.Val364Met Single submitter ⚠
p.Val446Met Single submitter ⚠
p.Val474Ile Single submitter ⚠
p.Val556Met Single submitter ⚠
p.Val667Ile Single submitter ⚠
p.Val769Met Single submitter ⚠
p.Val808Met Single submitter ⚠