BCAR3 — 153 ClinVar variants
All ClinVar germline BCAR3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 146 flagged for review →
3 Benign · 7 Likely benign · 143 Uncertain significance
Full BCAR3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 146
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 101
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- BCAR3 p.Ala196Ser Uncertain significance Single submitter
- BCAR3 p.Ala196Thr Uncertain significance Single submitter
- BCAR3 p.Ala211Asp Uncertain significance Single submitter
- BCAR3 p.Ala391Val Uncertain significance Single submitter
- BCAR3 p.Ala41Gly Uncertain significance Single submitter
- BCAR3 p.Ala490Val Uncertain significance Single submitter
- BCAR3 p.Ala535Val Uncertain significance Single submitter
- BCAR3 p.Ala634Val Uncertain significance Single submitter
- BCAR3 p.Arg158Cys Uncertain significance Single submitter
- BCAR3 p.Arg207Gln Uncertain significance Single submitter
- BCAR3 p.Arg274Gln Uncertain significance Single submitter
- BCAR3 p.Arg288Lys Uncertain significance Single submitter
- BCAR3 p.Arg299Gln Uncertain significance Single submitter
- BCAR3 p.Arg380Gln Uncertain significance Single submitter
- BCAR3 p.Arg469Leu Uncertain significance Single submitter
- BCAR3 p.Arg595Cys Uncertain significance Single submitter
- BCAR3 p.Arg719Cys Uncertain significance Single submitter
- BCAR3 p.Arg719His Uncertain significance Single submitter
- BCAR3 p.Arg813His Uncertain significance Single submitter
- BCAR3 p.Asn307Asp Uncertain significance Single submitter
- BCAR3 p.Asn424Ser Uncertain significance Single submitter
- BCAR3 p.Asn424Thr Uncertain significance Single submitter
- BCAR3 p.Asn463Ser Uncertain significance Single submitter
- BCAR3 p.Asn518Asp Uncertain significance Single submitter
- BCAR3 p.Asn518Lys Uncertain significance Single submitter
- BCAR3 p.Asn529Lys Uncertain significance Single submitter
- BCAR3 p.Asp480Val Uncertain significance Single submitter
- BCAR3 p.Asp548Asn Uncertain significance Single submitter
- BCAR3 p.Asp639Glu Uncertain significance Single submitter
- BCAR3 p.Asp728Asn Uncertain significance Single submitter
- BCAR3 p.Asp734Asn Uncertain significance Single submitter
- BCAR3 p.Asp88Gly Uncertain significance Single submitter
- BCAR3 p.Asp97Ala Uncertain significance Single submitter
- BCAR3 p.Cys346Arg Uncertain significance Single submitter
- BCAR3 p.Gln243Arg Uncertain significance Single submitter
- BCAR3 p.Gln87Pro Uncertain significance Single submitter
- BCAR3 p.Gln96His Uncertain significance Single submitter
- BCAR3 p.Glu101Lys Uncertain significance Single submitter
- BCAR3 p.Glu220Lys Uncertain significance Single submitter
- BCAR3 p.Glu222Asp Uncertain significance Single submitter
- BCAR3 p.Glu456Gln Uncertain significance Single submitter
- BCAR3 p.Glu464Ala Uncertain significance Single submitter
- BCAR3 p.Glu503Lys Uncertain significance Single submitter
- BCAR3 p.Glu752Lys Uncertain significance Single submitter
- BCAR3 p.Glu776Asp Uncertain significance Single submitter
- BCAR3 p.Gly100Ser Uncertain significance Single submitter
- BCAR3 p.Gly157Ser Uncertain significance Single submitter
- BCAR3 p.Gly281Arg Uncertain significance Single submitter
- BCAR3 p.Gly441Ser Uncertain significance Single submitter
- BCAR3 p.Gly591Arg Uncertain significance Single submitter
- BCAR3 p.Gly789Ala Uncertain significance Single submitter
- BCAR3 p.His109Arg Uncertain significance Single submitter
- BCAR3 p.His324Gln Uncertain significance Single submitter
- BCAR3 p.His37Leu Uncertain significance Single submitter
- BCAR3 p.His592Arg Uncertain significance Single submitter
- BCAR3 p.His602Tyr Uncertain significance Single submitter
- BCAR3 p.Ile126Leu Uncertain significance Single submitter
- BCAR3 p.Ile253Val Uncertain significance Single submitter
- BCAR3 p.Ile344Thr Uncertain significance Single submitter
- BCAR3 p.Ile586Val Uncertain significance Single submitter
- BCAR3 p.Ile598Val Uncertain significance Single submitter
- BCAR3 p.Ile599Thr Uncertain significance Single submitter
- BCAR3 p.Ile613Val Uncertain significance Single submitter
- BCAR3 p.Ile90Leu Uncertain significance Single submitter
- BCAR3 p.Leu111Pro Uncertain significance Single submitter
- BCAR3 p.Leu28Val Uncertain significance Single submitter
- BCAR3 p.Leu413Arg Uncertain significance Single submitter
- BCAR3 p.Leu457Arg Uncertain significance Single submitter
- BCAR3 p.Leu596Arg Uncertain significance Single submitter
- BCAR3 p.Leu644Phe Uncertain significance Single submitter
- BCAR3 p.Leu650Phe Uncertain significance Single submitter
- BCAR3 p.Leu811Phe Uncertain significance Single submitter
- BCAR3 p.Lys347Arg Uncertain significance Single submitter
- BCAR3 p.Lys414Gln Uncertain significance Single submitter
- BCAR3 p.Met293Thr Uncertain significance Single submitter
- BCAR3 p.Met559Ile Uncertain significance Single submitter
- BCAR3 p.Met559Thr Uncertain significance Single submitter
- BCAR3 p.Met651Thr Uncertain significance Single submitter
- BCAR3 p.Met729Val Uncertain significance Single submitter
- BCAR3 p.Met750Thr Uncertain significance Single submitter
- BCAR3 p.Phe504Ser Uncertain significance Single submitter
- BCAR3 p.Phe544Val Uncertain significance Single submitter
- BCAR3 p.Pro258Ser Uncertain significance Single submitter
- BCAR3 p.Pro361Arg Uncertain significance Single submitter
- BCAR3 p.Pro411Ser Uncertain significance Single submitter
- BCAR3 p.Pro527Ala Uncertain significance Single submitter
- BCAR3 p.Pro60Ala Uncertain significance Single submitter
- BCAR3 p.Pro770Ser Uncertain significance Single submitter
- BCAR3 p.Ser181Phe Uncertain significance Single submitter
- BCAR3 p.Thr368Ser Uncertain significance Single submitter
- BCAR3 p.Thr459Arg Uncertain significance Single submitter
- BCAR3 p.Thr506Met Uncertain significance Single submitter
- BCAR3 p.Thr715Met Uncertain significance Single submitter
- BCAR3 p.Trp192Arg Uncertain significance Single submitter
- BCAR3 p.Trp499Arg Uncertain significance Single submitter
- BCAR3 p.Tyr266Cys Uncertain significance Single submitter
- BCAR3 p.Tyr801Asp Uncertain significance Single submitter
- BCAR3 p.Val296Leu Uncertain significance Single submitter
- BCAR3 p.Val410Met Uncertain significance Single submitter
- BCAR3 p.Val512Ile Uncertain significance Single submitter
- BCAR3 p.Val707Phe Uncertain significance Single submitter
Predictors split 45
The independent predictors disagree with each other — read with care.
- BCAR3 p.Arg758Gln Uncertain significance Multiple submitters
- BCAR3 p.Ala247Thr Uncertain significance Single submitter
- BCAR3 p.Ala624Val Likely benign Single submitter
- BCAR3 p.Ala761Val Uncertain significance Single submitter
- BCAR3 p.Arg150Cys Uncertain significance Single submitter
- BCAR3 p.Arg150His Uncertain significance Single submitter
- BCAR3 p.Arg203Gln Uncertain significance Single submitter
- BCAR3 p.Arg214His Uncertain significance Single submitter
- BCAR3 p.Arg214Leu Uncertain significance Single submitter
- BCAR3 p.Arg238Cys Uncertain significance Single submitter
- BCAR3 p.Arg239Gln Uncertain significance Single submitter
- BCAR3 p.Arg260Trp Uncertain significance Single submitter
- BCAR3 p.Arg380Trp Uncertain significance Single submitter
- BCAR3 p.Arg574Gly Uncertain significance Single submitter
- BCAR3 p.Arg695Thr Uncertain significance Single submitter
- BCAR3 p.Arg785Gln Uncertain significance Single submitter
- BCAR3 p.Arg80Trp Uncertain significance Single submitter
- BCAR3 p.Arg98Trp Likely benign Single submitter
- BCAR3 p.Asn603His Uncertain significance Single submitter
- BCAR3 p.Asp479Val Uncertain significance Single submitter
- BCAR3 p.Asp612His Uncertain significance Single submitter
- BCAR3 p.Cys778Gly Uncertain significance Single submitter
- BCAR3 p.Glu132Lys Uncertain significance Single submitter
- BCAR3 p.Glu210Lys Likely benign Single submitter
- BCAR3 p.Glu521Gly Uncertain significance Single submitter
- BCAR3 p.His75Tyr Uncertain significance Single submitter
- BCAR3 p.Ile248Met Uncertain significance Single submitter
- BCAR3 p.Leu303Phe Uncertain significance Single submitter
- BCAR3 p.Leu73His Uncertain significance Single submitter
- BCAR3 p.Leu73Pro Uncertain significance Single submitter
- BCAR3 p.Lys664Glu Uncertain significance Single submitter
- BCAR3 p.Lys682Asn Uncertain significance Single submitter
- BCAR3 p.Phe219Leu Uncertain significance Single submitter
- BCAR3 p.Pro712Leu Uncertain significance Single submitter
- BCAR3 p.Pro817Ala Uncertain significance Single submitter
- BCAR3 p.Ser340Cys Uncertain significance Single submitter
- BCAR3 p.Ser358Asn Uncertain significance Single submitter
- BCAR3 p.Ser417Leu Uncertain significance Single submitter
- BCAR3 p.Ser8Asn Uncertain significance Single submitter
- BCAR3 p.Thr130Ile Uncertain significance Single submitter
- BCAR3 p.Thr746Ile Uncertain significance Single submitter
- BCAR3 p.Tyr673Asn Uncertain significance Single submitter
- BCAR3 p.Val215Met Uncertain significance Single submitter
- BCAR3 p.Val231Leu Uncertain significance Single submitter
- BCAR3 p.Val235Met Uncertain significance Single submitter
All BCAR3 variants
Benign 3
- p.Asn733Ser Multiple submitters
- p.Thr506= Multiple submitters
- p.Tyr645Cys Single submitter
Likely benign 7
- p.Ala624Val Single submitter ⚠
- p.Arg575Lys Single submitter
- p.Arg98Trp Single submitter ⚠
- p.Glu210Lys Single submitter ⚠
- p.Phe412Leu Single submitter
- p.Pro466Leu Single submitter
- p.Val556Ile Single submitter
Uncertain significance 143
- p.Arg758Gln Multiple submitters ⚠
- p.Ala196Ser Single submitter ⚠
- p.Ala196Thr Single submitter ⚠
- p.Ala211Asp Single submitter ⚠
- p.Ala247Thr Single submitter ⚠
- p.Ala391Val Single submitter ⚠
- p.Ala41Gly Single submitter ⚠
- p.Ala490Val Single submitter ⚠
- p.Ala535Val Single submitter ⚠
- p.Ala634Val Single submitter ⚠
- p.Ala761Val Single submitter ⚠
- p.Arg150Cys Single submitter ⚠
- p.Arg150His Single submitter ⚠
- p.Arg158Cys Single submitter ⚠
- p.Arg203Gln Single submitter ⚠
- p.Arg207Gln Single submitter ⚠
- p.Arg214His Single submitter ⚠
- p.Arg214Leu Single submitter ⚠
- p.Arg238Cys Single submitter ⚠
- p.Arg239Gln Single submitter ⚠
- p.Arg260Trp Single submitter ⚠
- p.Arg274Gln Single submitter ⚠
- p.Arg288Lys Single submitter ⚠
- p.Arg299Gln Single submitter ⚠
- p.Arg380Gln Single submitter ⚠
- p.Arg380Trp Single submitter ⚠
- p.Arg469Leu Single submitter ⚠
- p.Arg574Gly Single submitter ⚠
- p.Arg595Cys Single submitter ⚠
- p.Arg695Thr Single submitter ⚠
- p.Arg719Cys Single submitter ⚠
- p.Arg719His Single submitter ⚠
- p.Arg785Gln Single submitter ⚠
- p.Arg80Trp Single submitter ⚠
- p.Arg813His Single submitter ⚠
- p.Asn307Asp Single submitter ⚠
- p.Asn424Ser Single submitter ⚠
- p.Asn424Thr Single submitter ⚠
- p.Asn463Ser Single submitter ⚠
- p.Asn518Asp Single submitter ⚠
- p.Asn518Lys Single submitter ⚠
- p.Asn529Lys Single submitter ⚠
- p.Asn603His Single submitter ⚠
- p.Asp479Val Single submitter ⚠
- p.Asp480Val Single submitter ⚠
- p.Asp548Asn Single submitter ⚠
- p.Asp612His Single submitter ⚠
- p.Asp639Glu Single submitter ⚠
- p.Asp728Asn Single submitter ⚠
- p.Asp734Asn Single submitter ⚠
- p.Asp88Gly Single submitter ⚠
- p.Asp97Ala Single submitter ⚠
- p.Cys346Arg Single submitter ⚠
- p.Cys778Gly Single submitter ⚠
- p.Gln243Arg Single submitter ⚠
- p.Gln87Pro Single submitter ⚠
- p.Gln96His Single submitter ⚠
- p.Glu101Lys Single submitter ⚠
- p.Glu132Lys Single submitter ⚠
- p.Glu220Lys Single submitter ⚠
- p.Glu222Asp Single submitter ⚠
- p.Glu456Gln Single submitter ⚠
- p.Glu464Ala Single submitter ⚠
- p.Glu503Lys Single submitter ⚠
- p.Glu521Gly Single submitter ⚠
- p.Glu752Lys Single submitter ⚠
- p.Glu776Asp Single submitter ⚠
- p.Gly100Ser Single submitter ⚠
- p.Gly157Ser Single submitter ⚠
- p.Gly281Arg Single submitter ⚠
- p.Gly441Ser Single submitter ⚠
- p.Gly591Arg Single submitter ⚠
- p.Gly789Ala Single submitter ⚠
- p.His109Arg Single submitter ⚠
- p.His324Gln Single submitter ⚠
- p.His37Leu Single submitter ⚠
- p.His592Arg Single submitter ⚠
- p.His602Tyr Single submitter ⚠
- p.His75Tyr Single submitter ⚠
- p.Ile126Leu Single submitter ⚠
- p.Ile248Met Single submitter ⚠
- p.Ile253Val Single submitter ⚠
- p.Ile344Thr Single submitter ⚠
- p.Ile586Val Single submitter ⚠
- p.Ile598Val Single submitter ⚠
- p.Ile599Thr Single submitter ⚠
- p.Ile613Val Single submitter ⚠
- p.Ile90Leu Single submitter ⚠
- p.Leu111Pro Single submitter ⚠
- p.Leu28Val Single submitter ⚠
- p.Leu303Phe Single submitter ⚠
- p.Leu413Arg Single submitter ⚠
- p.Leu457Arg Single submitter ⚠
- p.Leu596Arg Single submitter ⚠
- p.Leu644Phe Single submitter ⚠
- p.Leu650Phe Single submitter ⚠
- p.Leu73His Single submitter ⚠
- p.Leu73Pro Single submitter ⚠
- p.Leu811Phe Single submitter ⚠
- p.Lys347Arg Single submitter ⚠
- p.Lys414Gln Single submitter ⚠
- p.Lys664Glu Single submitter ⚠
- p.Lys682Asn Single submitter ⚠
- p.Met293Thr Single submitter ⚠
- p.Met559Ile Single submitter ⚠
- p.Met559Thr Single submitter ⚠
- p.Met651Thr Single submitter ⚠
- p.Met729Val Single submitter ⚠
- p.Met750Thr Single submitter ⚠
- p.Phe219Leu Single submitter ⚠
- p.Phe504Ser Single submitter ⚠
- p.Phe544Val Single submitter ⚠
- p.Pro258Ser Single submitter ⚠
- p.Pro361Arg Single submitter ⚠
- p.Pro411Ser Single submitter ⚠
- p.Pro527Ala Single submitter ⚠
- p.Pro60Ala Single submitter ⚠
- p.Pro712Leu Single submitter ⚠
- p.Pro770Ser Single submitter ⚠
- p.Pro817Ala Single submitter ⚠
- p.Ser181Phe Single submitter ⚠
- p.Ser340Cys Single submitter ⚠
- p.Ser358Asn Single submitter ⚠
- p.Ser417Leu Single submitter ⚠
- p.Ser8Asn Single submitter ⚠
- p.Thr130Ile Single submitter ⚠
- p.Thr368Ser Single submitter ⚠
- p.Thr459Arg Single submitter ⚠
- p.Thr506Met Single submitter ⚠
- p.Thr715Met Single submitter ⚠
- p.Thr746Ile Single submitter ⚠
- p.Trp192Arg Single submitter ⚠
- p.Trp499Arg Single submitter ⚠
- p.Tyr266Cys Single submitter ⚠
- p.Tyr673Asn Single submitter ⚠
- p.Tyr801Asp Single submitter ⚠
- p.Val215Met Single submitter ⚠
- p.Val231Leu Single submitter ⚠
- p.Val235Met Single submitter ⚠
- p.Val296Leu Single submitter ⚠
- p.Val410Met Single submitter ⚠
- p.Val512Ile Single submitter ⚠
- p.Val707Phe Single submitter ⚠