BCCIP — 38 ClinVar variants
All ClinVar germline BCCIP variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 33 flagged for review →
4 Likely benign · 34 Uncertain significance
Full BCCIP gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 33
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 28
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- BCCIP p.Ala204Val Uncertain significance Single submitter
- BCCIP p.Ala206Ser Uncertain significance Single submitter
- BCCIP p.Ala245Thr Uncertain significance Single submitter
- BCCIP p.Ala245Val Uncertain significance Single submitter
- BCCIP p.Arg151Cys Uncertain significance Single submitter
- BCCIP p.Arg151His Uncertain significance Single submitter
- BCCIP p.Arg208Thr Uncertain significance Single submitter
- BCCIP p.Arg24Cys Uncertain significance Single submitter
- BCCIP p.Arg4Gly Uncertain significance Single submitter
- BCCIP p.Asn240Lys Uncertain significance Single submitter
- BCCIP p.Asn58Ser Uncertain significance Single submitter
- BCCIP p.Asp110Gly Uncertain significance Single submitter
- BCCIP p.Asp25Glu Uncertain significance Single submitter
- BCCIP p.Asp40Asn Uncertain significance Single submitter
- BCCIP p.Asp43Gly Uncertain significance Single submitter
- BCCIP p.Gln16Pro Uncertain significance Single submitter
- BCCIP p.Gln98Glu Uncertain significance Single submitter
- BCCIP p.Glu29Gln Uncertain significance Single submitter
- BCCIP p.Glu48Lys Uncertain significance Single submitter
- BCCIP p.His101Arg Uncertain significance Single submitter
- BCCIP p.His207Pro Uncertain significance Single submitter
- BCCIP p.Lys30Glu Uncertain significance Single submitter
- BCCIP p.Lys44Arg Uncertain significance Single submitter
- BCCIP p.Lys46Asn Uncertain significance Single submitter
- BCCIP p.Met119Thr Uncertain significance Single submitter
- BCCIP p.Phe255Val Uncertain significance Single submitter
- BCCIP p.Pro212Ala Uncertain significance Single submitter
- BCCIP p.Val105Gly Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All BCCIP variants
Likely benign 4
- p.Glu11Gly Single submitter
- p.Ile53Val Single submitter
- p.Met119Val Single submitter
- p.Ser5Pro Single submitter
Uncertain significance 34
- p.Ala204Val Single submitter ⚠
- p.Ala206Ser Single submitter ⚠
- p.Ala245Thr Single submitter ⚠
- p.Ala245Val Single submitter ⚠
- p.Arg151Cys Single submitter ⚠
- p.Arg151His Single submitter ⚠
- p.Arg208Thr Single submitter ⚠
- p.Arg24Cys Single submitter ⚠
- p.Arg4Gly Single submitter ⚠
- p.Arg7Gly Single submitter ⚠
- p.Asn240Lys Single submitter ⚠
- p.Asn58Ser Single submitter ⚠
- p.Asp110Gly Single submitter ⚠
- p.Asp25Glu Single submitter ⚠
- p.Asp40Asn Single submitter ⚠
- p.Asp43Gly Single submitter ⚠
- p.Asp68Val Single submitter ⚠
- p.Gln16Pro Single submitter ⚠
- p.Gln98Glu Single submitter ⚠
- p.Gln99His Single submitter ⚠
- p.Glu29Gln Single submitter ⚠
- p.Glu48Lys Single submitter ⚠
- p.Gly138Asp Single submitter ⚠
- p.Gly214Arg Single submitter
- p.His101Arg Single submitter ⚠
- p.His207Pro Single submitter ⚠
- p.Lys30Glu Single submitter ⚠
- p.Lys44Arg Single submitter ⚠
- p.Lys46Asn Single submitter ⚠
- p.Lys6Glu Single submitter ⚠
- p.Met119Thr Single submitter ⚠
- p.Phe255Val Single submitter ⚠
- p.Pro212Ala Single submitter ⚠
- p.Val105Gly Single submitter ⚠