BCL2L1 — 5 ClinVar variants
All ClinVar germline BCL2L1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 5 flagged for review →
5 Uncertain significance
Full BCL2L1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 5
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 5
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- BCL2L1 p.Arg209His Uncertain significance Single submitter
- BCL2L1 p.Glu202Lys Uncertain significance Single submitter
-
BCL2L1 p.Leu225Pro
Uncertain significance
Single submitter
hereditary breast ovarian cancer syndrome
- BCL2L1 p.Pro82Ser Uncertain significance Single submitter
- BCL2L1 p.Ser203Asn Uncertain significance Single submitter
All BCL2L1 variants
Uncertain significance 5
- p.Arg209His Single submitter ⚠
- p.Glu202Lys Single submitter ⚠
- p.Leu225Pro Single submitter hereditary breast ovarian cancer syndrome ⚠
- p.Pro82Ser Single submitter ⚠
- p.Ser203Asn Single submitter ⚠