BCL2L10 — 33 ClinVar variants
All ClinVar germline BCL2L10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 31 flagged for review →
1 Benign · 1 Likely benign · 31 Uncertain significance
Full BCL2L10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 31
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 21
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- BCL2L10 p.Ala116Pro Uncertain significance Single submitter
- BCL2L10 p.Ala116Thr Uncertain significance Single submitter
- BCL2L10 p.Ala155Thr Uncertain significance Single submitter
- BCL2L10 p.Ala40Val Uncertain significance Single submitter
- BCL2L10 p.Arg117Gly Uncertain significance Single submitter
- BCL2L10 p.Arg6Pro Uncertain significance Single submitter
- BCL2L10 p.Arg74Cys Uncertain significance Single submitter
- BCL2L10 p.Asp3Glu Uncertain significance Single submitter
- BCL2L10 p.Gln124His Uncertain significance Single submitter
- BCL2L10 p.Gln160His Uncertain significance Single submitter
- BCL2L10 p.Gly151Glu Uncertain significance Single submitter
- BCL2L10 p.Gly28Trp Uncertain significance Single submitter
- BCL2L10 p.Ile59Thr Uncertain significance Single submitter
- BCL2L10 p.Pro37Ser Uncertain significance Single submitter
- BCL2L10 p.Pro90Ser Uncertain significance Single submitter
- BCL2L10 p.Thr10Ile Uncertain significance Single submitter
- BCL2L10 p.Thr115Ser Uncertain significance Single submitter
- BCL2L10 p.Thr201Ala Uncertain significance Single submitter
- BCL2L10 p.Trp200Cys Uncertain significance Single submitter
- BCL2L10 p.Val101Leu Uncertain significance Single submitter
- BCL2L10 p.Val48Glu Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- BCL2L10 p.Arg61Pro Uncertain significance Single submitter
- BCL2L10 p.Asp13Gly Uncertain significance Single submitter
- BCL2L10 p.Asp13His Uncertain significance Single submitter
- BCL2L10 p.Asp25Glu Uncertain significance Single submitter
- BCL2L10 p.Cys190Arg Uncertain significance Single submitter
- BCL2L10 p.Gly122Val Uncertain significance Single submitter
- BCL2L10 p.Phe103Leu Uncertain significance Single submitter
- BCL2L10 p.Pro92Ser Uncertain significance Single submitter
- BCL2L10 p.Thr43Met Uncertain significance Single submitter
- BCL2L10 p.Val134Gly Uncertain significance Single submitter
All BCL2L10 variants
Benign 1
- p.Leu21Arg Multiple submitters
Likely benign 1
- p.Gln139Arg Single submitter
Uncertain significance 31
- p.Ala116Pro Single submitter ⚠
- p.Ala116Thr Single submitter ⚠
- p.Ala155Thr Single submitter ⚠
- p.Ala40Val Single submitter ⚠
- p.Arg117Gly Single submitter ⚠
- p.Arg61Pro Single submitter ⚠
- p.Arg6Pro Single submitter ⚠
- p.Arg74Cys Single submitter ⚠
- p.Asp13Gly Single submitter ⚠
- p.Asp13His Single submitter ⚠
- p.Asp25Glu Single submitter ⚠
- p.Asp3Glu Single submitter ⚠
- p.Cys190Arg Single submitter ⚠
- p.Gln124His Single submitter ⚠
- p.Gln160His Single submitter ⚠
- p.Gly122Val Single submitter ⚠
- p.Gly151Glu Single submitter ⚠
- p.Gly28Trp Single submitter ⚠
- p.Ile59Thr Single submitter ⚠
- p.Phe103Leu Single submitter ⚠
- p.Pro37Ser Single submitter ⚠
- p.Pro90Ser Single submitter ⚠
- p.Pro92Ser Single submitter ⚠
- p.Thr10Ile Single submitter ⚠
- p.Thr115Ser Single submitter ⚠
- p.Thr201Ala Single submitter ⚠
- p.Thr43Met Single submitter ⚠
- p.Trp200Cys Single submitter ⚠
- p.Val101Leu Single submitter ⚠
- p.Val134Gly Single submitter ⚠
- p.Val48Glu Single submitter ⚠