BCL2L11 — 28 ClinVar variants
All ClinVar germline BCL2L11 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 24 flagged for review →
2 Benign · 1 Likely benign · 25 Uncertain significance
Full BCL2L11 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 24
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 20
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- BCL2L11 p.Ala161Thr Uncertain significance Single submitter
- BCL2L11 p.Ala32Thr Uncertain significance Single submitter
- BCL2L11 p.Arg14Gly Uncertain significance Single submitter
- BCL2L11 p.Arg154His Uncertain significance Single submitter
- BCL2L11 p.Arg188Cys Uncertain significance Single submitter
- BCL2L11 p.Arg188His Uncertain significance Single submitter
- BCL2L11 p.Asn43Asp Uncertain significance Single submitter
- BCL2L11 p.Asn47Ser Uncertain significance Single submitter
- BCL2L11 p.Asp141Asn Uncertain significance Single submitter
- BCL2L11 p.Gly50Arg Uncertain significance Single submitter
- BCL2L11 p.Ile146Met Uncertain significance Single submitter
- BCL2L11 p.Ile190Val Uncertain significance Single submitter
- BCL2L11 p.Leu28Val Uncertain significance Single submitter
- BCL2L11 p.Met134Lys Uncertain significance Single submitter
- BCL2L11 p.Pro63Leu Uncertain significance Single submitter
- BCL2L11 p.Pro70Arg Uncertain significance Single submitter
- BCL2L11 p.Ser35Pro Uncertain significance Single submitter
- BCL2L11 p.Val167Ile Uncertain significance Single submitter
- BCL2L11 p.Val194Met Uncertain significance Single submitter
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BCL2L11 p.Arg192His
Uncertain significance
No assertion criteria
BCL2L11-related condition
Predictors split 4
The independent predictors disagree with each other — read with care.
All BCL2L11 variants
Benign 2
- c.499-2716A>G Multiple submitters
- p.Asp13= Multiple submitters
Likely benign 1
- p.Val167= Single submitter
Uncertain significance 25
- p.Ala123Thr Single submitter ⚠
- p.Ala161Thr Single submitter ⚠
- p.Ala32Thr Single submitter ⚠
- p.Arg14Gly Single submitter ⚠
- p.Arg154His Single submitter ⚠
- p.Arg188Cys Single submitter ⚠
- p.Arg188His Single submitter ⚠
- p.Arg29Gly Single submitter
- p.Asn160Lys Single submitter ⚠
- p.Asn43Asp Single submitter ⚠
- p.Asn47Ser Single submitter ⚠
- p.Asp141Asn Single submitter ⚠
- p.Gly50Arg Single submitter ⚠
- p.Ile146Met Single submitter ⚠
- p.Ile190Val Single submitter ⚠
- p.Leu152Trp Single submitter ⚠
- p.Leu28Val Single submitter ⚠
- p.Met134Lys Single submitter ⚠
- p.Pro63Leu Single submitter ⚠
- p.Pro70Arg Single submitter ⚠
- p.Ser35Pro Single submitter ⚠
- p.Ser98Phe Single submitter ⚠
- p.Val167Ile Single submitter ⚠
- p.Val194Met Single submitter ⚠
- p.Arg192His No assertion criteria BCL2L11-related condition ⚠