BCL2L15 — 25 ClinVar variants
All ClinVar germline BCL2L15 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 24 flagged for review →
1 Likely benign · 24 Uncertain significance
Full BCL2L15 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 24
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 8
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- BCL2L15 p.Asn65Ser Uncertain significance Single submitter
- BCL2L15 p.Cys35Arg Uncertain significance Single submitter
- BCL2L15 p.Gly157Val Uncertain significance Single submitter
- BCL2L15 p.Leu27Ser Uncertain significance Single submitter
- BCL2L15 p.Met141Ile Uncertain significance Single submitter
- BCL2L15 p.Met20Val Uncertain significance Single submitter
- BCL2L15 p.Thr26Ala Uncertain significance Single submitter
- BCL2L15 p.Thr79Ile Uncertain significance Single submitter
Predictors split 16
The independent predictors disagree with each other — read with care.
- BCL2L15 p.Ala72Ser Uncertain significance Single submitter
- BCL2L15 p.Arg149Gln Uncertain significance Single submitter
- BCL2L15 p.Arg149Trp Uncertain significance Single submitter
- BCL2L15 p.Arg58Trp Uncertain significance Single submitter
- BCL2L15 p.Asn143Ser Uncertain significance Single submitter
- BCL2L15 p.Asp103Asn Uncertain significance Single submitter
- BCL2L15 p.Cys13Ser Uncertain significance Single submitter
- BCL2L15 p.Gln5Glu Uncertain significance Single submitter
- BCL2L15 p.Ile152Met Uncertain significance Single submitter
- BCL2L15 p.Ile53Thr Uncertain significance Single submitter
- BCL2L15 p.Leu119Phe Uncertain significance Single submitter
- BCL2L15 p.Phe151Leu Uncertain significance Single submitter
- BCL2L15 p.Ser105Ile Uncertain significance Single submitter
- BCL2L15 p.Ser116Ala Uncertain significance Single submitter
- BCL2L15 p.Thr26Ile Uncertain significance Single submitter
- BCL2L15 p.Val50Met Uncertain significance Single submitter
All BCL2L15 variants
Likely benign 1
- p.Ser4Pro Single submitter
Uncertain significance 24
- p.Ala72Ser Single submitter ⚠
- p.Arg149Gln Single submitter ⚠
- p.Arg149Trp Single submitter ⚠
- p.Arg58Trp Single submitter ⚠
- p.Asn143Ser Single submitter ⚠
- p.Asn65Ser Single submitter ⚠
- p.Asp103Asn Single submitter ⚠
- p.Cys13Ser Single submitter ⚠
- p.Cys35Arg Single submitter ⚠
- p.Gln5Glu Single submitter ⚠
- p.Gly157Val Single submitter ⚠
- p.Ile152Met Single submitter ⚠
- p.Ile53Thr Single submitter ⚠
- p.Leu119Phe Single submitter ⚠
- p.Leu27Ser Single submitter ⚠
- p.Met141Ile Single submitter ⚠
- p.Met20Val Single submitter ⚠
- p.Phe151Leu Single submitter ⚠
- p.Ser105Ile Single submitter ⚠
- p.Ser116Ala Single submitter ⚠
- p.Thr26Ala Single submitter ⚠
- p.Thr26Ile Single submitter ⚠
- p.Thr79Ile Single submitter ⚠
- p.Val50Met Single submitter ⚠