BCL3 — 62 ClinVar variants
All ClinVar germline BCL3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 59 flagged for review →
3 Benign · 1 Likely benign · 58 Uncertain significance
Full BCL3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 59
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 21
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- BCL3 p.Ala45Asp Uncertain significance Single submitter
- BCL3 p.Ala46Ser Uncertain significance Single submitter
- BCL3 p.Ala51Glu Uncertain significance Single submitter
- BCL3 p.Ala68Val Uncertain significance Single submitter
- BCL3 p.Ala8Thr Uncertain significance Single submitter
- BCL3 p.Arg172Gln Uncertain significance Single submitter
- BCL3 p.Arg222Gln Uncertain significance Single submitter
- BCL3 p.Arg443Gln Uncertain significance Single submitter
- BCL3 p.Asn105Lys Uncertain significance Single submitter
- BCL3 p.Asn170His Uncertain significance Single submitter
- BCL3 p.Asp65Asn Uncertain significance Single submitter
- BCL3 p.Gly276Cys Uncertain significance Single submitter
- BCL3 p.Gly452Ala Uncertain significance Single submitter
- BCL3 p.Gly62Arg Uncertain significance Single submitter
- BCL3 p.Ile268Ser Uncertain significance Single submitter
- BCL3 p.Leu82Phe Uncertain significance Single submitter
- BCL3 p.Met416Thr Uncertain significance Single submitter
- BCL3 p.Pro100Leu Uncertain significance Single submitter
- BCL3 p.Pro418Ala Uncertain significance Single submitter
- BCL3 p.Pro444Leu Uncertain significance Single submitter
- BCL3 p.Pro449Ala Uncertain significance Single submitter
Predictors split 38
The independent predictors disagree with each other — read with care.
- BCL3 p.Val258Met Uncertain significance Multiple submitters
- BCL3 p.Ala126Thr Uncertain significance Single submitter
- BCL3 p.Ala22Thr Uncertain significance Single submitter
- BCL3 p.Ala270Gly Uncertain significance Single submitter
- BCL3 p.Ala45Thr Uncertain significance Single submitter
- BCL3 p.Ala45Val Uncertain significance Single submitter
- BCL3 p.Arg130Cys Uncertain significance Single submitter
- BCL3 p.Arg130His Uncertain significance Single submitter
- BCL3 p.Arg153Gln Uncertain significance Single submitter
- BCL3 p.Arg172Leu Uncertain significance Single submitter
- BCL3 p.Arg352His Uncertain significance Single submitter
- BCL3 p.Arg3Gln Uncertain significance Single submitter
- BCL3 p.Arg443Trp Uncertain significance Single submitter
- BCL3 p.Arg61His Uncertain significance Single submitter
- BCL3 p.Asn170Ser Uncertain significance Single submitter
- BCL3 p.Glu214Gln Uncertain significance Single submitter
- BCL3 p.Glu43Lys Uncertain significance Single submitter
- BCL3 p.Gly162Ser Uncertain significance Single submitter
- BCL3 p.Leu321Ile Uncertain significance Single submitter
- BCL3 p.Leu32Phe Uncertain significance Single submitter
- BCL3 p.Leu82Pro Uncertain significance Single submitter
- BCL3 p.Leu82Val Uncertain significance Single submitter
- BCL3 p.Met113Ile Uncertain significance Single submitter
- BCL3 p.Met199Thr Benign Single submitter
- BCL3 p.Phe434Leu Uncertain significance Single submitter
- BCL3 p.Pro112His Uncertain significance Single submitter
- BCL3 p.Pro26Ser Uncertain significance Single submitter
- BCL3 p.Pro36Leu Uncertain significance Single submitter
- BCL3 p.Pro399Gln Uncertain significance Single submitter
- BCL3 p.Pro407Ser Uncertain significance Single submitter
- BCL3 p.Pro42Ala Uncertain significance Single submitter
- BCL3 p.Pro444Gln Uncertain significance Single submitter
- BCL3 p.Pro44Thr Uncertain significance Single submitter
- BCL3 p.Pro67Ser Uncertain significance Single submitter
- BCL3 p.Pro70Ser Uncertain significance Single submitter
- BCL3 p.Pro72Ser Uncertain significance Single submitter
- BCL3 p.Pro79Leu Uncertain significance Single submitter
- BCL3 p.Val248Met Uncertain significance Single submitter
All BCL3 variants
Benign 3
- p.Leu294= Multiple submitters
- p.Asn303= Single submitter
- p.Met199Thr Single submitter ⚠
Likely benign 1
- c.1177+10C>T Single submitter
Uncertain significance 58
- p.Val258Met Multiple submitters ⚠
- p.Ala126Thr Single submitter ⚠
- p.Ala22Thr Single submitter ⚠
- p.Ala270Gly Single submitter ⚠
- p.Ala45Asp Single submitter ⚠
- p.Ala45Thr Single submitter ⚠
- p.Ala45Val Single submitter ⚠
- p.Ala46Ser Single submitter ⚠
- p.Ala51Glu Single submitter ⚠
- p.Ala68Val Single submitter ⚠
- p.Ala8Thr Single submitter ⚠
- p.Arg130Cys Single submitter ⚠
- p.Arg130His Single submitter ⚠
- p.Arg153Gln Single submitter ⚠
- p.Arg172Gln Single submitter ⚠
- p.Arg172Leu Single submitter ⚠
- p.Arg222Gln Single submitter ⚠
- p.Arg352His Single submitter ⚠
- p.Arg3Gln Single submitter ⚠
- p.Arg443Gln Single submitter ⚠
- p.Arg443Trp Single submitter ⚠
- p.Arg61His Single submitter ⚠
- p.Asn105Lys Single submitter ⚠
- p.Asn170His Single submitter ⚠
- p.Asn170Ser Single submitter ⚠
- p.Asp65Asn Single submitter ⚠
- p.Glu214Gln Single submitter ⚠
- p.Glu43Lys Single submitter ⚠
- p.Gly162Ser Single submitter ⚠
- p.Gly276Cys Single submitter ⚠
- p.Gly452Ala Single submitter ⚠
- p.Gly62Arg Single submitter ⚠
- p.Ile268Ser Single submitter ⚠
- p.Leu321Ile Single submitter ⚠
- p.Leu32Phe Single submitter ⚠
- p.Leu82Phe Single submitter ⚠
- p.Leu82Pro Single submitter ⚠
- p.Leu82Val Single submitter ⚠
- p.Met113Ile Single submitter ⚠
- p.Met416Thr Single submitter ⚠
- p.Phe434Leu Single submitter ⚠
- p.Pro100Leu Single submitter ⚠
- p.Pro112His Single submitter ⚠
- p.Pro26Ser Single submitter ⚠
- p.Pro36Leu Single submitter ⚠
- p.Pro399Gln Single submitter ⚠
- p.Pro407Ser Single submitter ⚠
- p.Pro418Ala Single submitter ⚠
- p.Pro42Ala Single submitter ⚠
- p.Pro444Gln Single submitter ⚠
- p.Pro444Leu Single submitter ⚠
- p.Pro449Ala Single submitter ⚠
- p.Pro44Thr Single submitter ⚠
- p.Pro67Ser Single submitter ⚠
- p.Pro70Ser Single submitter ⚠
- p.Pro72Ser Single submitter ⚠
- p.Pro79Leu Single submitter ⚠
- p.Val248Met Single submitter ⚠