BCL6 — 65 ClinVar variants
All ClinVar germline BCL6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 57 flagged for review →
4 Benign · 5 Likely benign · 56 Uncertain significance
Full BCL6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 57
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 39
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- BCL6 p.Ala107Thr Uncertain significance Single submitter
- BCL6 p.Ala291Thr Uncertain significance Single submitter
- BCL6 p.Ala390Asp Uncertain significance Single submitter
- BCL6 p.Arg236Lys Uncertain significance Single submitter
- BCL6 p.Arg26Trp Uncertain significance Single submitter
- BCL6 p.Arg402Cys Uncertain significance Single submitter
- BCL6 p.Arg406Gln Uncertain significance Single submitter
- BCL6 p.Arg445Trp Uncertain significance Single submitter
- BCL6 p.Arg692Cys Uncertain significance Single submitter
- BCL6 p.Arg692His Uncertain significance Single submitter
- BCL6 p.Arg94Gln Uncertain significance Single submitter
- BCL6 p.Asn145His Uncertain significance Single submitter
- BCL6 p.Asn252Asp Uncertain significance Single submitter
- BCL6 p.Asp543Glu Uncertain significance Single submitter
- BCL6 p.Cys414Tyr Uncertain significance Single submitter
- BCL6 p.Glu131Asp Uncertain significance Single submitter
- BCL6 p.Glu268Gly Uncertain significance Single submitter
- BCL6 p.Glu311Asp Uncertain significance Single submitter
- BCL6 p.Glu317Lys Uncertain significance Single submitter
- BCL6 p.Glu500Asp Uncertain significance Single submitter
- BCL6 p.Glu701Asp Uncertain significance Single submitter
- BCL6 p.Gly456Arg Uncertain significance Single submitter
- BCL6 p.Ile154Phe Uncertain significance Single submitter
- BCL6 p.Ile78Met Uncertain significance Single submitter
- BCL6 p.Leu665Val Uncertain significance Single submitter
- BCL6 p.Met418Leu Uncertain significance Single submitter
- BCL6 p.Pro192Ser Uncertain significance Single submitter
- BCL6 p.Pro237Gln Uncertain significance Single submitter
- BCL6 p.Pro245Leu Uncertain significance Single submitter
- BCL6 p.Pro295Ala Uncertain significance Single submitter
- BCL6 p.Pro392Ser Uncertain significance Single submitter
- BCL6 p.Pro412Leu Uncertain significance Single submitter
- BCL6 p.Pro417Ala Uncertain significance Single submitter
- BCL6 p.Pro458Ser Uncertain significance Single submitter
- BCL6 p.Pro473Thr Uncertain significance Single submitter
- BCL6 p.Pro4Leu Uncertain significance Single submitter
- BCL6 p.Ser183Asn Uncertain significance Single submitter
- BCL6 p.Ser385Asn Uncertain significance Single submitter
- BCL6 p.Ser434Arg Uncertain significance Single submitter
Predictors split 18
The independent predictors disagree with each other — read with care.
- BCL6 p.Ala562Thr Uncertain significance Single submitter
- BCL6 p.Arg147Trp Uncertain significance Single submitter
- BCL6 p.Arg244Trp Uncertain significance Single submitter
- BCL6 p.Arg325Trp Uncertain significance Single submitter
- BCL6 p.Arg535Thr Uncertain significance Single submitter
- BCL6 p.Arg550Cys Uncertain significance Single submitter
- BCL6 p.Asp210His Uncertain significance Single submitter
- BCL6 p.Gln10His Uncertain significance Single submitter
- BCL6 p.His616Gln Uncertain significance Single submitter
- BCL6 p.Leu423Phe Uncertain significance Single submitter
- BCL6 p.Leu533Ile Uncertain significance Single submitter
- BCL6 p.Lys534Asn Uncertain significance Single submitter
- BCL6 p.Lys662Asn Uncertain significance Single submitter
- BCL6 p.Phe213Leu Likely benign Single submitter
- BCL6 p.Pro151Ser Uncertain significance Single submitter
- BCL6 p.Pro370His Uncertain significance Single submitter
- BCL6 p.Ser464Ile Uncertain significance Single submitter
- BCL6 p.Thr409Met Uncertain significance Single submitter
All BCL6 variants
Benign 4
- c.161+8A>T Multiple submitters
- p.Ser209= Multiple submitters
- p.Thr48= Multiple submitters
- p.Ser694= Single submitter
Likely benign 5
- c.1356-3T>C Multiple submitters
- p.Pro245= Multiple submitters
- p.Arg402His Single submitter
- p.Glu227= Single submitter
- p.Phe213Leu Single submitter ⚠
Uncertain significance 56
- p.Ala107Thr Single submitter ⚠
- p.Ala291Thr Single submitter ⚠
- p.Ala390Asp Single submitter ⚠
- p.Ala562Thr Single submitter ⚠
- p.Arg147Trp Single submitter ⚠
- p.Arg236Lys Single submitter ⚠
- p.Arg244Trp Single submitter ⚠
- p.Arg26Trp Single submitter ⚠
- p.Arg325Trp Single submitter ⚠
- p.Arg402Cys Single submitter ⚠
- p.Arg406Gln Single submitter ⚠
- p.Arg445Trp Single submitter ⚠
- p.Arg535Thr Single submitter ⚠
- p.Arg550Cys Single submitter ⚠
- p.Arg692Cys Single submitter ⚠
- p.Arg692His Single submitter ⚠
- p.Arg94Gln Single submitter ⚠
- p.Asn145His Single submitter ⚠
- p.Asn252Asp Single submitter ⚠
- p.Asp210His Single submitter ⚠
- p.Asp543Glu Single submitter ⚠
- p.Cys414Tyr Single submitter ⚠
- p.Gln10His Single submitter ⚠
- p.Glu131Asp Single submitter ⚠
- p.Glu268Gly Single submitter ⚠
- p.Glu311Asp Single submitter ⚠
- p.Glu317Lys Single submitter ⚠
- p.Glu500Asp Single submitter ⚠
- p.Glu701Asp Single submitter ⚠
- p.Gly456Arg Single submitter ⚠
- p.His616Gln Single submitter ⚠
- p.Ile154Phe Single submitter ⚠
- p.Ile78Met Single submitter ⚠
- p.Leu423Phe Single submitter ⚠
- p.Leu533Ile Single submitter ⚠
- p.Leu665Val Single submitter ⚠
- p.Lys534Asn Single submitter ⚠
- p.Lys662Asn Single submitter ⚠
- p.Met418Leu Single submitter ⚠
- p.Pro151Ser Single submitter ⚠
- p.Pro192Ser Single submitter ⚠
- p.Pro237Gln Single submitter ⚠
- p.Pro245Leu Single submitter ⚠
- p.Pro295Ala Single submitter ⚠
- p.Pro370His Single submitter ⚠
- p.Pro392Ser Single submitter ⚠
- p.Pro412Leu Single submitter ⚠
- p.Pro417Ala Single submitter ⚠
- p.Pro458Ser Single submitter ⚠
- p.Pro473Thr Single submitter ⚠
- p.Pro4Leu Single submitter ⚠
- p.Ser183Asn Single submitter ⚠
- p.Ser385Asn Single submitter ⚠
- p.Ser434Arg Single submitter ⚠
- p.Ser464Ile Single submitter ⚠
- p.Thr409Met Single submitter ⚠