BCL6B — 26 ClinVar variants
All ClinVar germline BCL6B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 24 flagged for review →
26 Uncertain significance
Full BCL6B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 24
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 17
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- BCL6B p.Ala209Pro Uncertain significance Single submitter
- BCL6B p.Arg143His Uncertain significance Single submitter
- BCL6B p.Arg163Cys Uncertain significance Single submitter
- BCL6B p.Asp231Glu Uncertain significance Single submitter
- BCL6B p.Gln179Arg Uncertain significance Single submitter
- BCL6B p.Glu8Asp Uncertain significance Single submitter
- BCL6B p.Glu8Lys Uncertain significance Single submitter
- BCL6B p.Gly159Asp Uncertain significance Single submitter
- BCL6B p.Gly74Val Uncertain significance Single submitter
- BCL6B p.Gly83Asp Uncertain significance Single submitter
- BCL6B p.Gly9Ala Uncertain significance Single submitter
- BCL6B p.Pro109Ser Uncertain significance Single submitter
- BCL6B p.Pro182Ser Uncertain significance Single submitter
- BCL6B p.Pro184Ser Uncertain significance Single submitter
- BCL6B p.Thr151Pro Uncertain significance Single submitter
- BCL6B p.Thr41Met Uncertain significance Single submitter
- BCL6B p.Val14Leu Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- BCL6B p.Arg34Cys Uncertain significance Single submitter
- BCL6B p.Pro109Arg Uncertain significance Single submitter
- BCL6B p.Ser65Pro Uncertain significance Single submitter
- BCL6B p.Tyr13Cys Uncertain significance Single submitter
- BCL6B p.Tyr13His Uncertain significance Single submitter
- BCL6B p.Val123Leu Uncertain significance Single submitter
- BCL6B p.Val77Met Uncertain significance Single submitter
All BCL6B variants
Uncertain significance 26
- p.Ala209Pro Single submitter ⚠
- p.Arg143His Single submitter ⚠
- p.Arg163Cys Single submitter ⚠
- p.Arg19Gly Single submitter
- p.Arg34Cys Single submitter ⚠
- p.Asp231Glu Single submitter ⚠
- p.Gln179Arg Single submitter ⚠
- p.Glu8Asp Single submitter ⚠
- p.Glu8Lys Single submitter ⚠
- p.Gly159Asp Single submitter ⚠
- p.Gly74Val Single submitter ⚠
- p.Gly83Asp Single submitter ⚠
- p.Gly9Ala Single submitter ⚠
- p.Pro109Arg Single submitter ⚠
- p.Pro109Ser Single submitter ⚠
- p.Pro182Ser Single submitter ⚠
- p.Pro184Ser Single submitter ⚠
- p.Ser104Cys Single submitter
- p.Ser65Pro Single submitter ⚠
- p.Thr151Pro Single submitter ⚠
- p.Thr41Met Single submitter ⚠
- p.Tyr13Cys Single submitter ⚠
- p.Tyr13His Single submitter ⚠
- p.Val123Leu Single submitter ⚠
- p.Val14Leu Single submitter ⚠
- p.Val77Met Single submitter ⚠