BCL7B — 19 ClinVar variants
All ClinVar germline BCL7B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 16 flagged for review →
3 Likely benign · 16 Uncertain significance
Full BCL7B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 16
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 11
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- BCL7B p.Ala155Gly Uncertain significance Single submitter
- BCL7B p.Arg130Cys Uncertain significance Single submitter
- BCL7B p.His125Leu Uncertain significance Single submitter
- BCL7B p.His125Pro Uncertain significance Single submitter
- BCL7B p.Leu83Pro Uncertain significance Single submitter
- BCL7B p.Pro115Leu Uncertain significance Single submitter
- BCL7B p.Thr131Met Uncertain significance Single submitter
- BCL7B p.Thr138Ala Uncertain significance Single submitter
- BCL7B p.Thr171Ala Uncertain significance Single submitter
- BCL7B p.Tyr101Cys Uncertain significance Single submitter
- BCL7B p.Val97Leu Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All BCL7B variants
Likely benign 3
- c.93-1396T>G Single submitter
- p.Ala199= Single submitter
- p.Asp99= Single submitter
Uncertain significance 16
- p.Ala155Gly Single submitter ⚠
- p.Arg130Cys Single submitter ⚠
- p.Arg187Pro Single submitter ⚠
- p.His125Leu Single submitter ⚠
- p.His125Pro Single submitter ⚠
- p.Leu83Pro Single submitter ⚠
- p.Phe73Leu Single submitter ⚠
- p.Pro115Leu Single submitter ⚠
- p.Ser2Leu Single submitter ⚠
- p.Ser75Phe Single submitter ⚠
- p.Thr131Met Single submitter ⚠
- p.Thr138Ala Single submitter ⚠
- p.Thr171Ala Single submitter ⚠
- p.Tyr101Cys Single submitter ⚠
- p.Val6Leu Single submitter ⚠
- p.Val97Leu Single submitter ⚠