BCL7C — 30 ClinVar variants
All ClinVar germline BCL7C variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 29 flagged for review →
1 Likely benign · 29 Uncertain significance
Full BCL7C gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 29
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 9
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- BCL7C p.Gly129Arg Uncertain significance Single submitter
- BCL7C p.Gly150Arg Uncertain significance Single submitter
- BCL7C p.Gly84Ala Uncertain significance Single submitter
- BCL7C p.Gly84Ser Uncertain significance Single submitter
- BCL7C p.Pro130Leu Uncertain significance Single submitter
- BCL7C p.Pro141Gln Uncertain significance Single submitter
- BCL7C p.Ser201Leu Uncertain significance Single submitter
- BCL7C p.Thr198Arg Uncertain significance Single submitter
- BCL7C p.Thr37Ala Uncertain significance Single submitter
Predictors split 20
The independent predictors disagree with each other — read with care.
- BCL7C p.Arg209His Uncertain significance Single submitter
- BCL7C p.Arg70His Uncertain significance Single submitter
- BCL7C p.Arg74Cys Uncertain significance Single submitter
- BCL7C p.Arg75Gln Uncertain significance Single submitter
- BCL7C p.Arg82Gln Uncertain significance Single submitter
- BCL7C p.Asp94Gly Uncertain significance Single submitter
- BCL7C p.Glu146Gln Uncertain significance Single submitter
- BCL7C p.Glu179Lys Uncertain significance Single submitter
- BCL7C p.Gly63Asp Uncertain significance Single submitter
- BCL7C p.Ile18Phe Uncertain significance Single submitter
- BCL7C p.Ile25Val Uncertain significance Single submitter
- BCL7C p.Pro121Leu Uncertain significance Single submitter
- BCL7C p.Pro141Arg Uncertain significance Single submitter
- BCL7C p.Pro160Ser Uncertain significance Single submitter
- BCL7C p.Pro206Arg Uncertain significance Single submitter
- BCL7C p.Pro206Gln Uncertain significance Single submitter
- BCL7C p.Pro215Ser Uncertain significance Single submitter
- BCL7C p.Ser103Leu Uncertain significance Single submitter
- BCL7C p.Ser69Cys Uncertain significance Single submitter
- BCL7C p.Thr118Asn Uncertain significance Single submitter
All BCL7C variants
Likely benign 1
- p.Arg142Gln Single submitter
Uncertain significance 29
- p.Arg209His Single submitter ⚠
- p.Arg70His Single submitter ⚠
- p.Arg74Cys Single submitter ⚠
- p.Arg75Gln Single submitter ⚠
- p.Arg82Gln Single submitter ⚠
- p.Asp94Gly Single submitter ⚠
- p.Glu146Gln Single submitter ⚠
- p.Glu179Lys Single submitter ⚠
- p.Gly129Arg Single submitter ⚠
- p.Gly150Arg Single submitter ⚠
- p.Gly63Asp Single submitter ⚠
- p.Gly84Ala Single submitter ⚠
- p.Gly84Ser Single submitter ⚠
- p.Ile18Phe Single submitter ⚠
- p.Ile25Val Single submitter ⚠
- p.Pro121Leu Single submitter ⚠
- p.Pro130Leu Single submitter ⚠
- p.Pro141Arg Single submitter ⚠
- p.Pro141Gln Single submitter ⚠
- p.Pro160Ser Single submitter ⚠
- p.Pro206Arg Single submitter ⚠
- p.Pro206Gln Single submitter ⚠
- p.Pro215Ser Single submitter ⚠
- p.Ser103Leu Single submitter ⚠
- p.Ser201Leu Single submitter ⚠
- p.Ser69Cys Single submitter ⚠
- p.Thr118Asn Single submitter ⚠
- p.Thr198Arg Single submitter ⚠
- p.Thr37Ala Single submitter ⚠