BEND3 — 109 ClinVar variants
All ClinVar germline BEND3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 102 flagged for review →
1 Benign · 6 Likely benign · 102 Uncertain significance
Full BEND3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 102
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 72
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- BEND3 p.Ala102Val Uncertain significance Single submitter
- BEND3 p.Ala122Gly Uncertain significance Single submitter
- BEND3 p.Ala161Thr Uncertain significance Single submitter
- BEND3 p.Ala250Val Uncertain significance Single submitter
- BEND3 p.Ala251Thr Uncertain significance Single submitter
- BEND3 p.Ala28Asp Uncertain significance Single submitter
- BEND3 p.Ala355Thr Uncertain significance Single submitter
- BEND3 p.Ala387Thr Uncertain significance Single submitter
- BEND3 p.Ala473Val Uncertain significance Single submitter
- BEND3 p.Ala487Val Uncertain significance Single submitter
- BEND3 p.Arg308Cys Uncertain significance Single submitter
- BEND3 p.Arg382Gly Uncertain significance Single submitter
- BEND3 p.Arg426Ser Uncertain significance Single submitter
- BEND3 p.Arg447Trp Uncertain significance Single submitter
- BEND3 p.Arg495Cys Uncertain significance Single submitter
- BEND3 p.Arg495His Uncertain significance Single submitter
- BEND3 p.Arg521Leu Uncertain significance Single submitter
- BEND3 p.Arg615Leu Uncertain significance Single submitter
- BEND3 p.Arg658His Uncertain significance Single submitter
- BEND3 p.Arg679Gly Uncertain significance Single submitter
- BEND3 p.Arg746His Uncertain significance Single submitter
- BEND3 p.Arg74Lys Uncertain significance Single submitter
- BEND3 p.Asn627His Uncertain significance Single submitter
- BEND3 p.Asp121Asn Uncertain significance Single submitter
- BEND3 p.Asp121His Uncertain significance Single submitter
- BEND3 p.Asp148His Uncertain significance Single submitter
- BEND3 p.Asp189Glu Uncertain significance Single submitter
- BEND3 p.Asp281Asn Uncertain significance Single submitter
- BEND3 p.Asp424Asn Uncertain significance Single submitter
- BEND3 p.Asp669Asn Uncertain significance Single submitter
- BEND3 p.Cys553Ser Uncertain significance Single submitter
- BEND3 p.Cys667Ser Uncertain significance Single submitter
- BEND3 p.Cys95Tyr Uncertain significance Single submitter
- BEND3 p.Gln273His Uncertain significance Single submitter
- BEND3 p.Gln362Glu Uncertain significance Single submitter
- BEND3 p.Gln655Arg Uncertain significance Single submitter
- BEND3 p.Glu327Lys Uncertain significance Single submitter
- BEND3 p.Glu421Lys Uncertain significance Single submitter
- BEND3 p.Glu520Gln Uncertain significance Single submitter
- BEND3 p.Gly147Glu Uncertain significance Single submitter
- BEND3 p.Gly263Ala Uncertain significance Single submitter
- BEND3 p.Gly352Val Uncertain significance Single submitter
- BEND3 p.Gly599Ser Uncertain significance Single submitter
- BEND3 p.His580Gln Uncertain significance Single submitter
- BEND3 p.His588Gln Uncertain significance Single submitter
- BEND3 p.His588Leu Uncertain significance Single submitter
- BEND3 p.Ile138Val Uncertain significance Single submitter
- BEND3 p.Ile17Met Uncertain significance Single submitter
- BEND3 p.Ile534Val Uncertain significance Single submitter
- BEND3 p.Ile570Val Uncertain significance Single submitter
- BEND3 p.Leu155Phe Uncertain significance Single submitter
- BEND3 p.Leu278His Uncertain significance Single submitter
- BEND3 p.Leu504Val Uncertain significance Single submitter
- BEND3 p.Lys239Arg Uncertain significance Single submitter
- BEND3 p.Lys239Ile Uncertain significance Single submitter
- BEND3 p.Phe284Ile Uncertain significance Single submitter
- BEND3 p.Phe358Ser Uncertain significance Single submitter
- BEND3 p.Phe573Leu Uncertain significance Single submitter
- BEND3 p.Pro174Leu Uncertain significance Single submitter
- BEND3 p.Pro663Leu Uncertain significance Single submitter
- BEND3 p.Pro677Thr Uncertain significance Single submitter
- BEND3 p.Pro687Thr Uncertain significance Single submitter
- BEND3 p.Pro774Thr Uncertain significance Single submitter
- BEND3 p.Ser181Arg Uncertain significance Single submitter
- BEND3 p.Ser46Gly Uncertain significance Single submitter
- BEND3 p.Tyr435Asn Uncertain significance Single submitter
- BEND3 p.Val10Glu Uncertain significance Single submitter
- BEND3 p.Val152Leu Uncertain significance Single submitter
- BEND3 p.Val257Met Uncertain significance Single submitter
- BEND3 p.Val34Met Uncertain significance Single submitter
- BEND3 p.Val44Ala Uncertain significance Single submitter
- BEND3 p.Val784Met Uncertain significance Single submitter
Predictors split 30
The independent predictors disagree with each other — read with care.
- BEND3 p.Arg177Trp Uncertain significance Single submitter
- BEND3 p.Arg269Cys Uncertain significance Single submitter
- BEND3 p.Arg297His Uncertain significance Single submitter
- BEND3 p.Arg343Gln Uncertain significance Single submitter
- BEND3 p.Arg426Cys Uncertain significance Single submitter
- BEND3 p.Arg475Cys Uncertain significance Single submitter
- BEND3 p.Arg624Cys Uncertain significance Single submitter
- BEND3 p.Arg76Gln Uncertain significance Single submitter
- BEND3 p.Arg76Trp Uncertain significance Single submitter
- BEND3 p.Arg87Trp Uncertain significance Single submitter
- BEND3 p.Arg89His Uncertain significance Single submitter
- BEND3 p.Glu312Gln Uncertain significance Single submitter
- BEND3 p.Glu442Asp Uncertain significance Single submitter
- BEND3 p.Glu520Lys Uncertain significance Single submitter
- BEND3 p.Gly263Arg Uncertain significance Single submitter
- BEND3 p.Gly571Ser Uncertain significance Single submitter
- BEND3 p.Ile529Phe Uncertain significance Single submitter
- BEND3 p.Ile611Phe Uncertain significance Single submitter
- BEND3 p.Ile729Met Uncertain significance Single submitter
- BEND3 p.Leu306Val Uncertain significance Single submitter
- BEND3 p.Phe200Leu Uncertain significance Single submitter
- BEND3 p.Pro330His Uncertain significance Single submitter
- BEND3 p.Pro445Leu Uncertain significance Single submitter
- BEND3 p.Pro691Ser Uncertain significance Single submitter
- BEND3 p.Ser262Thr Uncertain significance Single submitter
- BEND3 p.Ser502Phe Uncertain significance Single submitter
- BEND3 p.Thr207Met Uncertain significance Single submitter
- BEND3 p.Val272Met Uncertain significance Single submitter
- BEND3 p.Val282Met Uncertain significance Single submitter
- BEND3 p.Val662Met Uncertain significance Single submitter
All BEND3 variants
Benign 1
- p.Leu480= Single submitter
Likely benign 6
- p.Asn110Ser Single submitter
- p.Gly103Ser Single submitter
- p.Gly366Ser Single submitter
- p.Ser43Pro Single submitter
- p.Tyr499= Single submitter
- p.Val44Leu Single submitter
Uncertain significance 102
- p.Ala102Val Single submitter ⚠
- p.Ala122Gly Single submitter ⚠
- p.Ala161Thr Single submitter ⚠
- p.Ala250Val Single submitter ⚠
- p.Ala251Thr Single submitter ⚠
- p.Ala28Asp Single submitter ⚠
- p.Ala355Thr Single submitter ⚠
- p.Ala387Thr Single submitter ⚠
- p.Ala473Val Single submitter ⚠
- p.Ala487Val Single submitter ⚠
- p.Arg177Trp Single submitter ⚠
- p.Arg269Cys Single submitter ⚠
- p.Arg297His Single submitter ⚠
- p.Arg308Cys Single submitter ⚠
- p.Arg343Gln Single submitter ⚠
- p.Arg382Gly Single submitter ⚠
- p.Arg426Cys Single submitter ⚠
- p.Arg426Ser Single submitter ⚠
- p.Arg447Trp Single submitter ⚠
- p.Arg475Cys Single submitter ⚠
- p.Arg495Cys Single submitter ⚠
- p.Arg495His Single submitter ⚠
- p.Arg521Leu Single submitter ⚠
- p.Arg615Leu Single submitter ⚠
- p.Arg624Cys Single submitter ⚠
- p.Arg658His Single submitter ⚠
- p.Arg679Gly Single submitter ⚠
- p.Arg746His Single submitter ⚠
- p.Arg74Lys Single submitter ⚠
- p.Arg76Gln Single submitter ⚠
- p.Arg76Trp Single submitter ⚠
- p.Arg87Trp Single submitter ⚠
- p.Arg89His Single submitter ⚠
- p.Asn627His Single submitter ⚠
- p.Asp121Asn Single submitter ⚠
- p.Asp121His Single submitter ⚠
- p.Asp148His Single submitter ⚠
- p.Asp189Glu Single submitter ⚠
- p.Asp281Asn Single submitter ⚠
- p.Asp424Asn Single submitter ⚠
- p.Asp669Asn Single submitter ⚠
- p.Cys553Ser Single submitter ⚠
- p.Cys667Ser Single submitter ⚠
- p.Cys95Tyr Single submitter ⚠
- p.Gln273His Single submitter ⚠
- p.Gln362Glu Single submitter ⚠
- p.Gln655Arg Single submitter ⚠
- p.Glu312Gln Single submitter ⚠
- p.Glu327Lys Single submitter ⚠
- p.Glu421Lys Single submitter ⚠
- p.Glu442Asp Single submitter ⚠
- p.Glu520Gln Single submitter ⚠
- p.Glu520Lys Single submitter ⚠
- p.Gly147Glu Single submitter ⚠
- p.Gly263Ala Single submitter ⚠
- p.Gly263Arg Single submitter ⚠
- p.Gly352Val Single submitter ⚠
- p.Gly571Ser Single submitter ⚠
- p.Gly599Ser Single submitter ⚠
- p.His580Gln Single submitter ⚠
- p.His588Gln Single submitter ⚠
- p.His588Leu Single submitter ⚠
- p.Ile138Val Single submitter ⚠
- p.Ile17Met Single submitter ⚠
- p.Ile529Phe Single submitter ⚠
- p.Ile534Val Single submitter ⚠
- p.Ile570Val Single submitter ⚠
- p.Ile611Phe Single submitter ⚠
- p.Ile729Met Single submitter ⚠
- p.Leu155Phe Single submitter ⚠
- p.Leu278His Single submitter ⚠
- p.Leu306Val Single submitter ⚠
- p.Leu504Val Single submitter ⚠
- p.Lys239Arg Single submitter ⚠
- p.Lys239Ile Single submitter ⚠
- p.Phe200Leu Single submitter ⚠
- p.Phe284Ile Single submitter ⚠
- p.Phe358Ser Single submitter ⚠
- p.Phe573Leu Single submitter ⚠
- p.Pro174Leu Single submitter ⚠
- p.Pro330His Single submitter ⚠
- p.Pro445Leu Single submitter ⚠
- p.Pro663Leu Single submitter ⚠
- p.Pro677Thr Single submitter ⚠
- p.Pro687Thr Single submitter ⚠
- p.Pro691Ser Single submitter ⚠
- p.Pro774Thr Single submitter ⚠
- p.Ser181Arg Single submitter ⚠
- p.Ser262Thr Single submitter ⚠
- p.Ser46Gly Single submitter ⚠
- p.Ser502Phe Single submitter ⚠
- p.Thr207Met Single submitter ⚠
- p.Tyr435Asn Single submitter ⚠
- p.Val10Glu Single submitter ⚠
- p.Val152Leu Single submitter ⚠
- p.Val257Met Single submitter ⚠
- p.Val272Met Single submitter ⚠
- p.Val282Met Single submitter ⚠
- p.Val34Met Single submitter ⚠
- p.Val44Ala Single submitter ⚠
- p.Val662Met Single submitter ⚠
- p.Val784Met Single submitter ⚠