BEND4 — 112 ClinVar variants
All ClinVar germline BEND4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 106 flagged for review →
6 Likely benign · 106 Uncertain significance
Full BEND4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 106
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 77
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- BEND4 p.Gln224Glu Uncertain significance Multiple submitters
- BEND4 p.Ser268Leu Uncertain significance Multiple submitters
- BEND4 p.Ala125Thr Uncertain significance Single submitter
- BEND4 p.Ala244Pro Uncertain significance Single submitter
- BEND4 p.Ala518Pro Uncertain significance Single submitter
- BEND4 p.Ala66Val Uncertain significance Single submitter
- BEND4 p.Ala82Pro Uncertain significance Single submitter
- BEND4 p.Ala97Pro Uncertain significance Single submitter
- BEND4 p.Arg165Gln Uncertain significance Single submitter
- BEND4 p.Arg451His Uncertain significance Single submitter
- BEND4 p.Arg498Trp Uncertain significance Single submitter
- BEND4 p.Arg92Gly Uncertain significance Single submitter
- BEND4 p.Asn209Ser Uncertain significance Single submitter
- BEND4 p.Asn228Ser Uncertain significance Single submitter
- BEND4 p.Asp278His Uncertain significance Single submitter
- BEND4 p.Asp489Val Uncertain significance Single submitter
- BEND4 p.Cys104Phe Uncertain significance Single submitter
- BEND4 p.Gln212Glu Uncertain significance Single submitter
- BEND4 p.Gln224His Uncertain significance Single submitter
- BEND4 p.Gln370Arg Uncertain significance Single submitter
- BEND4 p.Gln517Pro Uncertain significance Single submitter
- BEND4 p.Glu159Gln Uncertain significance Single submitter
- BEND4 p.Glu3Lys Uncertain significance Single submitter
- BEND4 p.Glu449Lys Uncertain significance Single submitter
- BEND4 p.Glu74Lys Uncertain significance Single submitter
- BEND4 p.Gly147Ala Uncertain significance Single submitter
- BEND4 p.Gly205Ser Uncertain significance Single submitter
- BEND4 p.Gly321Ser Uncertain significance Single submitter
- BEND4 p.His275Pro Uncertain significance Single submitter
- BEND4 p.His51Gln Uncertain significance Single submitter
- BEND4 p.His65Arg Uncertain significance Single submitter
- BEND4 p.Ile231Met Uncertain significance Single submitter
- BEND4 p.Ile334Met Uncertain significance Single submitter
- BEND4 p.Ile419Phe Uncertain significance Single submitter
- BEND4 p.Leu188Phe Uncertain significance Single submitter
- BEND4 p.Leu276Val Uncertain significance Single submitter
- BEND4 p.Leu27Phe Uncertain significance Single submitter
- BEND4 p.Leu358Ile Uncertain significance Single submitter
- BEND4 p.Lys19Arg Uncertain significance Single submitter
- BEND4 p.Lys33Arg Uncertain significance Single submitter
- BEND4 p.Met197Val Uncertain significance Single submitter
- BEND4 p.Met363Val Uncertain significance Single submitter
- BEND4 p.Phe132Cys Uncertain significance Single submitter
- BEND4 p.Phe62Val Uncertain significance Single submitter
- BEND4 p.Pro102Leu Uncertain significance Single submitter
- BEND4 p.Pro140Arg Uncertain significance Single submitter
- BEND4 p.Pro140Thr Uncertain significance Single submitter
- BEND4 p.Pro23Leu Uncertain significance Single submitter
- BEND4 p.Pro265Ala Uncertain significance Single submitter
- BEND4 p.Pro281Leu Uncertain significance Single submitter
- BEND4 p.Pro35Ser Uncertain significance Single submitter
- BEND4 p.Pro374Thr Uncertain significance Single submitter
- BEND4 p.Pro448Leu Uncertain significance Single submitter
- BEND4 p.Pro61Ser Uncertain significance Single submitter
- BEND4 p.Pro7Arg Uncertain significance Single submitter
- BEND4 p.Pro7Gln Uncertain significance Single submitter
- BEND4 p.Pro88Ala Uncertain significance Single submitter
- BEND4 p.Pro88Leu Uncertain significance Single submitter
- BEND4 p.Pro90Ser Uncertain significance Single submitter
- BEND4 p.Ser153Arg Uncertain significance Single submitter
- BEND4 p.Ser155Arg Uncertain significance Single submitter
- BEND4 p.Ser180Asn Uncertain significance Single submitter
- BEND4 p.Ser207Thr Uncertain significance Single submitter
- BEND4 p.Ser259Trp Uncertain significance Single submitter
- BEND4 p.Ser271Gly Uncertain significance Single submitter
- BEND4 p.Ser471Cys Uncertain significance Single submitter
- BEND4 p.Ser479Leu Uncertain significance Single submitter
- BEND4 p.Thr284Ala Uncertain significance Single submitter
- BEND4 p.Thr381Ala Uncertain significance Single submitter
- BEND4 p.Tyr322Cys Uncertain significance Single submitter
- BEND4 p.Tyr41Cys Uncertain significance Single submitter
- BEND4 p.Tyr41His Uncertain significance Single submitter
- BEND4 p.Tyr511Phe Uncertain significance Single submitter
- BEND4 p.Val279Met Uncertain significance Single submitter
- BEND4 p.Val287Ala Uncertain significance Single submitter
- BEND4 p.Val523Ile Uncertain significance Single submitter
-
BEND4 p.Gly433Ser
Uncertain significance
No assertion criteria
familial acute necrotizing encephalopathy
Predictors split 29
The independent predictors disagree with each other — read with care.
- BEND4 p.Ala94Thr Uncertain significance Single submitter
- BEND4 p.Arg177Gln Uncertain significance Single submitter
- BEND4 p.Arg43Pro Uncertain significance Single submitter
- BEND4 p.Arg498Gln Uncertain significance Single submitter
- BEND4 p.Asn389Lys Uncertain significance Single submitter
- BEND4 p.Cys200Trp Uncertain significance Single submitter
- BEND4 p.Gln174His Uncertain significance Single submitter
- BEND4 p.Gln327Pro Uncertain significance Single submitter
- BEND4 p.Glu319Lys Uncertain significance Single submitter
- BEND4 p.Gly147Asp Uncertain significance Single submitter
- BEND4 p.Gly149Cys Uncertain significance Single submitter
- BEND4 p.Gly152Asp Uncertain significance Single submitter
- BEND4 p.Gly507Arg Uncertain significance Single submitter
- BEND4 p.Ile483Met Uncertain significance Single submitter
- BEND4 p.Phe62Leu Uncertain significance Single submitter
- BEND4 p.Pro119Gln Uncertain significance Single submitter
- BEND4 p.Pro124Leu Uncertain significance Single submitter
- BEND4 p.Pro55Leu Uncertain significance Single submitter
- BEND4 p.Pro55Ser Uncertain significance Single submitter
- BEND4 p.Ser157Asn Uncertain significance Single submitter
- BEND4 p.Ser157Ile Uncertain significance Single submitter
- BEND4 p.Ser72Arg Uncertain significance Single submitter
- BEND4 p.Ser73Ile Uncertain significance Single submitter
- BEND4 p.Thr151Met Uncertain significance Single submitter
- BEND4 p.Thr425Ala Uncertain significance Single submitter
- BEND4 p.Tyr24His Uncertain significance Single submitter
- BEND4 p.Tyr417His Uncertain significance Single submitter
- BEND4 p.Val136Ile Uncertain significance Single submitter
- BEND4 p.Val404Leu Uncertain significance Single submitter
All BEND4 variants
Likely benign 6
- p.Pro473= Multiple submitters
- p.Asn192Ser Single submitter
- p.Gln118Pro Single submitter
- p.Glu42= Single submitter
- p.Pro61_Phe62insProProPro Single submitter
- p.Thr148Ser Single submitter
Uncertain significance 106
- p.Gln224Glu Multiple submitters ⚠
- p.Ser268Leu Multiple submitters ⚠
- p.Ala125Thr Single submitter ⚠
- p.Ala244Pro Single submitter ⚠
- p.Ala518Pro Single submitter ⚠
- p.Ala66Val Single submitter ⚠
- p.Ala82Pro Single submitter ⚠
- p.Ala94Thr Single submitter ⚠
- p.Ala97Pro Single submitter ⚠
- p.Arg165Gln Single submitter ⚠
- p.Arg177Gln Single submitter ⚠
- p.Arg43Pro Single submitter ⚠
- p.Arg451His Single submitter ⚠
- p.Arg498Gln Single submitter ⚠
- p.Arg498Trp Single submitter ⚠
- p.Arg92Gly Single submitter ⚠
- p.Asn209Ser Single submitter ⚠
- p.Asn228Ser Single submitter ⚠
- p.Asn389Lys Single submitter ⚠
- p.Asp278His Single submitter ⚠
- p.Asp489Val Single submitter ⚠
- p.Cys104Phe Single submitter ⚠
- p.Cys200Trp Single submitter ⚠
- p.Gln174His Single submitter ⚠
- p.Gln212Glu Single submitter ⚠
- p.Gln224His Single submitter ⚠
- p.Gln327Pro Single submitter ⚠
- p.Gln370Arg Single submitter ⚠
- p.Gln517Pro Single submitter ⚠
- p.Glu159Gln Single submitter ⚠
- p.Glu319Lys Single submitter ⚠
- p.Glu3Lys Single submitter ⚠
- p.Glu449Lys Single submitter ⚠
- p.Glu74Lys Single submitter ⚠
- p.Gly147Ala Single submitter ⚠
- p.Gly147Asp Single submitter ⚠
- p.Gly149Cys Single submitter ⚠
- p.Gly152Asp Single submitter ⚠
- p.Gly205Ser Single submitter ⚠
- p.Gly321Ser Single submitter ⚠
- p.Gly507Arg Single submitter ⚠
- p.His275Pro Single submitter ⚠
- p.His51Gln Single submitter ⚠
- p.His65Arg Single submitter ⚠
- p.Ile231Met Single submitter ⚠
- p.Ile334Met Single submitter ⚠
- p.Ile419Phe Single submitter ⚠
- p.Ile483Met Single submitter ⚠
- p.Leu188Phe Single submitter ⚠
- p.Leu276Val Single submitter ⚠
- p.Leu27Phe Single submitter ⚠
- p.Leu358Ile Single submitter ⚠
- p.Lys19Arg Single submitter ⚠
- p.Lys33Arg Single submitter ⚠
- p.Met197Val Single submitter ⚠
- p.Met363Val Single submitter ⚠
- p.Phe132Cys Single submitter ⚠
- p.Phe62Leu Single submitter ⚠
- p.Phe62Val Single submitter ⚠
- p.Pro102Leu Single submitter ⚠
- p.Pro119Gln Single submitter ⚠
- p.Pro124Leu Single submitter ⚠
- p.Pro140Arg Single submitter ⚠
- p.Pro140Thr Single submitter ⚠
- p.Pro23Leu Single submitter ⚠
- p.Pro265Ala Single submitter ⚠
- p.Pro281Leu Single submitter ⚠
- p.Pro35Ser Single submitter ⚠
- p.Pro374Thr Single submitter ⚠
- p.Pro448Leu Single submitter ⚠
- p.Pro55Leu Single submitter ⚠
- p.Pro55Ser Single submitter ⚠
- p.Pro61Ser Single submitter ⚠
- p.Pro7Arg Single submitter ⚠
- p.Pro7Gln Single submitter ⚠
- p.Pro88Ala Single submitter ⚠
- p.Pro88Leu Single submitter ⚠
- p.Pro90Ser Single submitter ⚠
- p.Ser153Arg Single submitter ⚠
- p.Ser155Arg Single submitter ⚠
- p.Ser157Asn Single submitter ⚠
- p.Ser157Ile Single submitter ⚠
- p.Ser180Asn Single submitter ⚠
- p.Ser207Thr Single submitter ⚠
- p.Ser259Trp Single submitter ⚠
- p.Ser271Gly Single submitter ⚠
- p.Ser471Cys Single submitter ⚠
- p.Ser479Leu Single submitter ⚠
- p.Ser72Arg Single submitter ⚠
- p.Ser73Ile Single submitter ⚠
- p.Thr151Met Single submitter ⚠
- p.Thr284Ala Single submitter ⚠
- p.Thr381Ala Single submitter ⚠
- p.Thr425Ala Single submitter ⚠
- p.Tyr24His Single submitter ⚠
- p.Tyr322Cys Single submitter ⚠
- p.Tyr417His Single submitter ⚠
- p.Tyr41Cys Single submitter ⚠
- p.Tyr41His Single submitter ⚠
- p.Tyr511Phe Single submitter ⚠
- p.Val136Ile Single submitter ⚠
- p.Val279Met Single submitter ⚠
- p.Val287Ala Single submitter ⚠
- p.Val404Leu Single submitter ⚠
- p.Val523Ile Single submitter ⚠
- p.Gly433Ser No assertion criteria familial acute necrotizing encephalopathy ⚠