BEND5 — 52 ClinVar variants
All ClinVar germline BEND5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 49 flagged for review →
3 Likely benign · 49 Uncertain significance
Full BEND5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 49
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 33
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- BEND5 p.Ala284Thr Uncertain significance Single submitter
- BEND5 p.Ala286Val Uncertain significance Single submitter
- BEND5 p.Ala49Gly Uncertain significance Single submitter
- BEND5 p.Ala63Ser Uncertain significance Single submitter
- BEND5 p.Arg206Gln Uncertain significance Single submitter
- BEND5 p.Arg269Gln Uncertain significance Single submitter
- BEND5 p.Asn296Asp Uncertain significance Single submitter
- BEND5 p.Asp308Glu Uncertain significance Single submitter
- BEND5 p.Asp403Tyr Uncertain significance Single submitter
- BEND5 p.Gln192Lys Uncertain significance Single submitter
- BEND5 p.Glu111Gly Uncertain significance Single submitter
- BEND5 p.Glu129Ala Uncertain significance Single submitter
- BEND5 p.Glu162Gly Uncertain significance Single submitter
- BEND5 p.Glu230Lys Uncertain significance Single submitter
- BEND5 p.Glu230Val Uncertain significance Single submitter
- BEND5 p.Gly50Arg Uncertain significance Single submitter
- BEND5 p.His152Arg Uncertain significance Single submitter
- BEND5 p.His313Gln Uncertain significance Single submitter
- BEND5 p.Ile119Met Uncertain significance Single submitter
- BEND5 p.Ile119Thr Uncertain significance Single submitter
- BEND5 p.Lys107Asn Uncertain significance Single submitter
- BEND5 p.Met170Val Uncertain significance Single submitter
- BEND5 p.Met86Val Uncertain significance Single submitter
- BEND5 p.Pro127Gln Uncertain significance Single submitter
- BEND5 p.Pro156Leu Uncertain significance Single submitter
- BEND5 p.Pro179Ser Uncertain significance Single submitter
- BEND5 p.Pro26Thr Uncertain significance Single submitter
- BEND5 p.Ser172Gly Uncertain significance Single submitter
- BEND5 p.Thr271Ala Uncertain significance Single submitter
- BEND5 p.Val161Leu Uncertain significance Single submitter
- BEND5 p.Val161Met Uncertain significance Single submitter
- BEND5 p.Val368Ile Uncertain significance Single submitter
- BEND5 p.Val381Gly Uncertain significance Single submitter
Predictors split 16
The independent predictors disagree with each other — read with care.
- BEND5 p.Arg125Trp Uncertain significance Single submitter
- BEND5 p.Arg188Cys Uncertain significance Single submitter
- BEND5 p.Arg198Cys Uncertain significance Single submitter
- BEND5 p.Asn405Ser Uncertain significance Single submitter
- BEND5 p.Gln388Arg Uncertain significance Single submitter
- BEND5 p.Glu136Lys Uncertain significance Single submitter
- BEND5 p.Glu265Lys Uncertain significance Single submitter
- BEND5 p.Glu45Lys Uncertain significance Single submitter
- BEND5 p.Glu9Lys Uncertain significance Single submitter
- BEND5 p.Leu47Trp Uncertain significance Single submitter
- BEND5 p.Pro17Ser Uncertain significance Single submitter
- BEND5 p.Ser25Asn Uncertain significance Single submitter
- BEND5 p.Ser279Leu Uncertain significance Single submitter
- BEND5 p.Trp306Cys Uncertain significance Single submitter
- BEND5 p.Val18Leu Uncertain significance Single submitter
-
BEND5 p.Ile404Val
Uncertain significance
No assertion criteria
prostate cancer
All BEND5 variants
Uncertain significance 49
- p.Ala284Thr Single submitter ⚠
- p.Ala286Val Single submitter ⚠
- p.Ala49Gly Single submitter ⚠
- p.Ala63Ser Single submitter ⚠
- p.Arg125Trp Single submitter ⚠
- p.Arg188Cys Single submitter ⚠
- p.Arg198Cys Single submitter ⚠
- p.Arg206Gln Single submitter ⚠
- p.Arg269Gln Single submitter ⚠
- p.Asn296Asp Single submitter ⚠
- p.Asn405Ser Single submitter ⚠
- p.Asp308Glu Single submitter ⚠
- p.Asp403Tyr Single submitter ⚠
- p.Gln192Lys Single submitter ⚠
- p.Gln388Arg Single submitter ⚠
- p.Glu111Gly Single submitter ⚠
- p.Glu129Ala Single submitter ⚠
- p.Glu136Lys Single submitter ⚠
- p.Glu162Gly Single submitter ⚠
- p.Glu230Lys Single submitter ⚠
- p.Glu230Val Single submitter ⚠
- p.Glu265Lys Single submitter ⚠
- p.Glu45Lys Single submitter ⚠
- p.Glu9Lys Single submitter ⚠
- p.Gly50Arg Single submitter ⚠
- p.His152Arg Single submitter ⚠
- p.His313Gln Single submitter ⚠
- p.Ile119Met Single submitter ⚠
- p.Ile119Thr Single submitter ⚠
- p.Leu47Trp Single submitter ⚠
- p.Lys107Asn Single submitter ⚠
- p.Met170Val Single submitter ⚠
- p.Met86Val Single submitter ⚠
- p.Pro127Gln Single submitter ⚠
- p.Pro156Leu Single submitter ⚠
- p.Pro179Ser Single submitter ⚠
- p.Pro17Ser Single submitter ⚠
- p.Pro26Thr Single submitter ⚠
- p.Ser172Gly Single submitter ⚠
- p.Ser25Asn Single submitter ⚠
- p.Ser279Leu Single submitter ⚠
- p.Thr271Ala Single submitter ⚠
- p.Trp306Cys Single submitter ⚠
- p.Val161Leu Single submitter ⚠
- p.Val161Met Single submitter ⚠
- p.Val18Leu Single submitter ⚠
- p.Val368Ile Single submitter ⚠
- p.Val381Gly Single submitter ⚠
- p.Ile404Val No assertion criteria prostate cancer ⚠