BICD1 — 116 ClinVar variants
All ClinVar germline BICD1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 103 flagged for review →
4 Benign · 4 Likely benign · 108 Uncertain significance
Full BICD1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 103
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 82
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- BICD1 p.Ala135Ser Uncertain significance Single submitter
- BICD1 p.Ala220Val Uncertain significance Single submitter
- BICD1 p.Ala360Thr Uncertain significance Single submitter
- BICD1 p.Arg153Gln Uncertain significance Single submitter
- BICD1 p.Arg159Gln Uncertain significance Single submitter
- BICD1 p.Arg167Trp Uncertain significance Single submitter
- BICD1 p.Arg338Gln Uncertain significance Single submitter
- BICD1 p.Arg367Trp Uncertain significance Single submitter
- BICD1 p.Arg370Gln Uncertain significance Single submitter
- BICD1 p.Arg805Gln Uncertain significance Single submitter
- BICD1 p.Arg806His Uncertain significance Single submitter
- BICD1 p.Arg868Cys Uncertain significance Single submitter
- BICD1 p.Arg915Trp Uncertain significance Single submitter
- BICD1 p.Asn281Ser Uncertain significance Single submitter
- BICD1 p.Asn495Ser Uncertain significance Single submitter
- BICD1 p.Asp11Asn Uncertain significance Single submitter
- BICD1 p.Asp139Asn Uncertain significance Single submitter
- BICD1 p.Asp429Glu Uncertain significance Single submitter
- BICD1 p.Asp553Asn Uncertain significance Single submitter
- BICD1 p.Asp614Glu Uncertain significance Single submitter
- BICD1 p.Asp949Gly Uncertain significance Single submitter
- BICD1 p.Cys523Ser Uncertain significance Single submitter
- BICD1 p.Cys923Ser Uncertain significance Single submitter
- BICD1 p.Cys968Ser Uncertain significance Single submitter
- BICD1 p.Gln488Arg Uncertain significance Single submitter
- BICD1 p.Gln51Arg Uncertain significance Single submitter
- BICD1 p.Gln906His Uncertain significance Single submitter
- BICD1 p.Glu157Lys Uncertain significance Single submitter
- BICD1 p.Glu209Gln Uncertain significance Single submitter
- BICD1 p.Glu486Asp Uncertain significance Single submitter
- BICD1 p.Glu58Lys Uncertain significance Single submitter
- BICD1 p.Gly380Val Uncertain significance Single submitter
- BICD1 p.Gly817Ser Uncertain significance Single submitter
- BICD1 p.Gly897Asp Uncertain significance Single submitter
- BICD1 p.His29Gln Uncertain significance Single submitter
- BICD1 p.His369Gln Uncertain significance Single submitter
- BICD1 p.His482Arg Uncertain significance Single submitter
- BICD1 p.His801Arg Uncertain significance Single submitter
- BICD1 p.His958Arg Uncertain significance Single submitter
- BICD1 p.Ile226Met Uncertain significance Single submitter
- BICD1 p.Ile410Val Uncertain significance Single submitter
- BICD1 p.Ile459Leu Uncertain significance Single submitter
- BICD1 p.Ile631Val Uncertain significance Single submitter
- BICD1 p.Ile816Thr Uncertain significance Single submitter
- BICD1 p.Leu116Met Uncertain significance Single submitter
- BICD1 p.Leu116Val Uncertain significance Single submitter
- BICD1 p.Leu311Pro Uncertain significance Single submitter
- BICD1 p.Leu344Ser Uncertain significance Single submitter
- BICD1 p.Leu709Ile Uncertain significance Single submitter
- BICD1 p.Leu881Phe Uncertain significance Single submitter
- BICD1 p.Lys22Arg Uncertain significance Single submitter
- BICD1 p.Lys454Arg Uncertain significance Single submitter
- BICD1 p.Lys454Thr Uncertain significance Single submitter
- BICD1 p.Lys63Arg Uncertain significance Single submitter
- BICD1 p.Lys667Arg Uncertain significance Single submitter
- BICD1 p.Lys912Arg Uncertain significance Single submitter
- BICD1 p.Met378Leu Uncertain significance Single submitter
- BICD1 p.Met378Val Uncertain significance Single submitter
- BICD1 p.Met719Val Uncertain significance Single submitter
- BICD1 p.Pro555Ala Uncertain significance Single submitter
- BICD1 p.Pro571Leu Uncertain significance Single submitter
- BICD1 p.Pro884Ala Uncertain significance Single submitter
- BICD1 p.Pro887Ser Uncertain significance Single submitter
- BICD1 p.Pro920Thr Uncertain significance Single submitter
- BICD1 p.Pro953Thr Uncertain significance Single submitter
- BICD1 p.Pro972Ser Uncertain significance Single submitter
- BICD1 p.Ser468Asn Uncertain significance Single submitter
- BICD1 p.Ser476Asn Uncertain significance Single submitter
- BICD1 p.Ser61Gly Uncertain significance Single submitter
- BICD1 p.Ser807Gly Uncertain significance Single submitter
- BICD1 p.Ser960Ile Uncertain significance Single submitter
- BICD1 p.Thr362Met Uncertain significance Single submitter
- BICD1 p.Thr503Met Uncertain significance Single submitter
- BICD1 p.Thr510Ala Uncertain significance Single submitter
- BICD1 p.Thr828Ala Uncertain significance Single submitter
- BICD1 p.Tyr13Phe Uncertain significance Single submitter
- BICD1 p.Tyr462Cys Uncertain significance Single submitter
- BICD1 p.Val126Ile Uncertain significance Single submitter
- BICD1 p.Val147Ala Uncertain significance Single submitter
- BICD1 p.Val267Gly Uncertain significance Single submitter
- BICD1 p.Val829Met Uncertain significance Single submitter
- BICD1 p.Val930Ile Uncertain significance Single submitter
Predictors split 21
The independent predictors disagree with each other — read with care.
- BICD1 p.Ala345Pro Uncertain significance Single submitter
- BICD1 p.Arg159Leu Uncertain significance Single submitter
- BICD1 p.Arg619His Uncertain significance Single submitter
- BICD1 p.Arg806Cys Uncertain significance Single submitter
- BICD1 p.Asp644His Uncertain significance Single submitter
- BICD1 p.Glu102Asp Uncertain significance Single submitter
- BICD1 p.Glu131Lys Uncertain significance Single submitter
- BICD1 p.Glu88Ala Uncertain significance Single submitter
- BICD1 p.Glu88Asp Uncertain significance Single submitter
- BICD1 p.His80Arg Uncertain significance Single submitter
- BICD1 p.Ile604Thr Uncertain significance Single submitter
- BICD1 p.Leu381Pro Uncertain significance Single submitter
- BICD1 p.Leu559Ser Uncertain significance Single submitter
- BICD1 p.Leu647Ser Uncertain significance Single submitter
- BICD1 p.Lys340Asn Uncertain significance Single submitter
- BICD1 p.Lys49Thr Uncertain significance Single submitter
- BICD1 p.Met112Thr Uncertain significance Single submitter
- BICD1 p.Phe318Val Uncertain significance Single submitter
- BICD1 p.Ser187Phe Uncertain significance Single submitter
- BICD1 p.Ser541Arg Uncertain significance Single submitter
- BICD1 p.Val83Phe Uncertain significance Single submitter
All BICD1 variants
Benign 4
Likely benign 4
- c.213+75_213+77del Single submitter
- p.Pro931= Single submitter
- p.Ser499Asn Single submitter
- p.Ser929= Single submitter
Uncertain significance 108
- p.Ala135Ser Single submitter ⚠
- p.Ala220Val Single submitter ⚠
- p.Ala345Pro Single submitter ⚠
- p.Ala360Thr Single submitter ⚠
- p.Arg153Gln Single submitter ⚠
- p.Arg159Gln Single submitter ⚠
- p.Arg159Leu Single submitter ⚠
- p.Arg167Trp Single submitter ⚠
- p.Arg338Gln Single submitter ⚠
- p.Arg367Trp Single submitter ⚠
- p.Arg370Gln Single submitter ⚠
- p.Arg545Cys Single submitter
- p.Arg545His Single submitter
- p.Arg619His Single submitter ⚠
- p.Arg805Gln Single submitter ⚠
- p.Arg806Cys Single submitter ⚠
- p.Arg806His Single submitter ⚠
- p.Arg868Cys Single submitter ⚠
- p.Arg915Trp Single submitter ⚠
- p.Asn281Ser Single submitter ⚠
- p.Asn495Ser Single submitter ⚠
- p.Asp11Asn Single submitter ⚠
- p.Asp139Asn Single submitter ⚠
- p.Asp429Glu Single submitter ⚠
- p.Asp553Asn Single submitter ⚠
- p.Asp614Glu Single submitter ⚠
- p.Asp644His Single submitter ⚠
- p.Asp949Gly Single submitter ⚠
- p.Cys523Ser Single submitter ⚠
- p.Cys923Ser Single submitter ⚠
- p.Cys968Ser Single submitter ⚠
- p.Gln488Arg Single submitter ⚠
- p.Gln51Arg Single submitter ⚠
- p.Gln906His Single submitter ⚠
- p.Glu102Asp Single submitter ⚠
- p.Glu131Gly Single submitter
- p.Glu131Lys Single submitter ⚠
- p.Glu157Lys Single submitter ⚠
- p.Glu209Gln Single submitter ⚠
- p.Glu486Asp Single submitter ⚠
- p.Glu58Lys Single submitter ⚠
- p.Glu88Ala Single submitter ⚠
- p.Glu88Asp Single submitter ⚠
- p.Gly380Val Single submitter ⚠
- p.Gly817Ser Single submitter ⚠
- p.Gly897Asp Single submitter ⚠
- p.His29Gln Single submitter ⚠
- p.His369Gln Single submitter ⚠
- p.His482Arg Single submitter ⚠
- p.His638Tyr Single submitter
- p.His801Arg Single submitter ⚠
- p.His80Arg Single submitter ⚠
- p.His958Arg Single submitter ⚠
- p.Ile226Met Single submitter ⚠
- p.Ile410Val Single submitter ⚠
- p.Ile459Leu Single submitter ⚠
- p.Ile604Thr Single submitter ⚠
- p.Ile631Val Single submitter ⚠
- p.Ile816Thr Single submitter ⚠
- p.Leu116Met Single submitter ⚠
- p.Leu116Val Single submitter ⚠
- p.Leu311Pro Single submitter ⚠
- p.Leu344Ser Single submitter ⚠
- p.Leu381Pro Single submitter ⚠
- p.Leu559Ser Single submitter ⚠
- p.Leu647Ser Single submitter ⚠
- p.Leu709Ile Single submitter ⚠
- p.Leu881Phe Single submitter ⚠
- p.Lys22Arg Single submitter ⚠
- p.Lys340Asn Single submitter ⚠
- p.Lys454Arg Single submitter ⚠
- p.Lys454Thr Single submitter ⚠
- p.Lys49Thr Single submitter ⚠
- p.Lys63Arg Single submitter ⚠
- p.Lys667Arg Single submitter ⚠
- p.Lys912Arg Single submitter ⚠
- p.Met112Thr Single submitter ⚠
- p.Met378Leu Single submitter ⚠
- p.Met378Val Single submitter ⚠
- p.Met719Val Single submitter ⚠
- p.Phe318Val Single submitter ⚠
- p.Pro555Ala Single submitter ⚠
- p.Pro571Leu Single submitter ⚠
- p.Pro884Ala Single submitter ⚠
- p.Pro887Ser Single submitter ⚠
- p.Pro920Thr Single submitter ⚠
- p.Pro953Thr Single submitter ⚠
- p.Pro972Ser Single submitter ⚠
- p.Ser187Phe Single submitter ⚠
- p.Ser468Asn Single submitter ⚠
- p.Ser476Asn Single submitter ⚠
- p.Ser541Arg Single submitter ⚠
- p.Ser61Gly Single submitter ⚠
- p.Ser807Gly Single submitter ⚠
- p.Ser960Ile Single submitter ⚠
- p.Thr362Met Single submitter ⚠
- p.Thr503Met Single submitter ⚠
- p.Thr510Ala Single submitter ⚠
- p.Thr828Ala Single submitter ⚠
- p.Tyr13Phe Single submitter ⚠
- p.Tyr462Cys Single submitter ⚠
- p.Val126Ile Single submitter ⚠
- p.Val147Ala Single submitter ⚠
- p.Val267Gly Single submitter ⚠
- p.Val368Gly Single submitter
- p.Val829Met Single submitter ⚠
- p.Val83Phe Single submitter ⚠
- p.Val930Ile Single submitter ⚠