BICRAL — 140 ClinVar variants
All ClinVar germline BICRAL variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 135 flagged for review →
4 Likely benign · 136 Uncertain significance
Full BICRAL gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 135
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 106
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- BICRAL p.Ala42Val Uncertain significance Single submitter
- BICRAL p.Ala479Gly Uncertain significance Single submitter
- BICRAL p.Ala546Gly Uncertain significance Single submitter
- BICRAL p.Ala695Val Uncertain significance Single submitter
- BICRAL p.Ala833Asp Uncertain significance Single submitter
- BICRAL p.Ala889Thr Uncertain significance Single submitter
- BICRAL p.Arg1022Gln Uncertain significance Single submitter
- BICRAL p.Arg586Cys Uncertain significance Single submitter
- BICRAL p.Arg724Gln Uncertain significance Single submitter
- BICRAL p.Arg808Gln Uncertain significance Single submitter
- BICRAL p.Arg811His Uncertain significance Single submitter
- BICRAL p.Arg841Gln Uncertain significance Single submitter
- BICRAL p.Arg864Gln Uncertain significance Single submitter
- BICRAL p.Arg902Thr Uncertain significance Single submitter
- BICRAL p.Arg941Gln Uncertain significance Single submitter
- BICRAL p.Arg946Ser Uncertain significance Single submitter
- BICRAL p.Arg978Gly Uncertain significance Single submitter
- BICRAL p.Asn263Ser Uncertain significance Single submitter
- BICRAL p.Asn330Ser Uncertain significance Single submitter
- BICRAL p.Asn44Ser Uncertain significance Single submitter
- BICRAL p.Asn51Ser Uncertain significance Single submitter
- BICRAL p.Asn54Ser Uncertain significance Single submitter
- BICRAL p.Asn786Ser Uncertain significance Single submitter
- BICRAL p.Asp795Asn Uncertain significance Single submitter
- BICRAL p.Cys899Tyr Uncertain significance Single submitter
- BICRAL p.Gln323Arg Uncertain significance Single submitter
- BICRAL p.Gln503Pro Uncertain significance Single submitter
- BICRAL p.Gln83Arg Uncertain significance Single submitter
- BICRAL p.Gln877Arg Uncertain significance Single submitter
- BICRAL p.Gln913Arg Uncertain significance Single submitter
- BICRAL p.Glu90Lys Uncertain significance Single submitter
- BICRAL p.Glu938Lys Uncertain significance Single submitter
- BICRAL p.Glu952Gly Uncertain significance Single submitter
- BICRAL p.Glu996Lys Uncertain significance Single submitter
- BICRAL p.Gly1032Ser Uncertain significance Single submitter
- BICRAL p.Gly341Ala Uncertain significance Single submitter
- BICRAL p.Gly392Ser Uncertain significance Single submitter
- BICRAL p.Gly39Val Uncertain significance Single submitter
- BICRAL p.Gly497Arg Uncertain significance Single submitter
- BICRAL p.Gly633Asp Uncertain significance Single submitter
- BICRAL p.Gly641Arg Uncertain significance Single submitter
- BICRAL p.Gly673Glu Uncertain significance Single submitter
- BICRAL p.Gly688Arg Uncertain significance Single submitter
- BICRAL p.Gly936Asp Uncertain significance Single submitter
- BICRAL p.His142Tyr Uncertain significance Single submitter
- BICRAL p.His845Leu Uncertain significance Single submitter
- BICRAL p.His879Arg Uncertain significance Single submitter
- BICRAL p.His940Leu Uncertain significance Single submitter
- BICRAL p.Ile130Met Uncertain significance Single submitter
- BICRAL p.Ile130Val Uncertain significance Single submitter
- BICRAL p.Ile166Thr Uncertain significance Single submitter
- BICRAL p.Ile228Val Uncertain significance Single submitter
- BICRAL p.Ile237Val Uncertain significance Single submitter
- BICRAL p.Ile342Phe Uncertain significance Single submitter
- BICRAL p.Ile363Val Uncertain significance Single submitter
- BICRAL p.Ile48Val Uncertain significance Single submitter
- BICRAL p.Ile639Val Uncertain significance Single submitter
- BICRAL p.Leu1001Ile Uncertain significance Single submitter
- BICRAL p.Leu291Val Uncertain significance Single submitter
- BICRAL p.Leu494Phe Uncertain significance Single submitter
- BICRAL p.Leu571Pro Uncertain significance Single submitter
- BICRAL p.Leu986Ser Uncertain significance Single submitter
- BICRAL p.Lys1005Glu Uncertain significance Single submitter
- BICRAL p.Lys1012Arg Uncertain significance Single submitter
- BICRAL p.Lys700Glu Uncertain significance Single submitter
- BICRAL p.Lys895Glu Uncertain significance Single submitter
- BICRAL p.Lys896Glu Uncertain significance Single submitter
- BICRAL p.Lys929Glu Uncertain significance Single submitter
- BICRAL p.Lys954Arg Uncertain significance Single submitter
- BICRAL p.Met873Arg Uncertain significance Single submitter
- BICRAL p.Met991Thr Uncertain significance Single submitter
- BICRAL p.Phe598Ser Uncertain significance Single submitter
- BICRAL p.Phe723Leu Uncertain significance Single submitter
- BICRAL p.Pro1056Leu Uncertain significance Single submitter
- BICRAL p.Pro429Ala Uncertain significance Single submitter
- BICRAL p.Pro461Leu Uncertain significance Single submitter
- BICRAL p.Pro484Ser Uncertain significance Single submitter
- BICRAL p.Pro551Ala Uncertain significance Single submitter
- BICRAL p.Pro648Ser Uncertain significance Single submitter
- BICRAL p.Pro676Ser Uncertain significance Single submitter
- BICRAL p.Pro679Ser Uncertain significance Single submitter
- BICRAL p.Pro855Gln Uncertain significance Single submitter
- BICRAL p.Pro937Leu Uncertain significance Single submitter
- BICRAL p.Pro999Ser Uncertain significance Single submitter
- BICRAL p.Ser129Asn Uncertain significance Single submitter
- BICRAL p.Ser241Gly Uncertain significance Single submitter
- BICRAL p.Ser269Ala Uncertain significance Single submitter
- BICRAL p.Ser512Pro Uncertain significance Single submitter
- BICRAL p.Ser552Ile Uncertain significance Single submitter
- BICRAL p.Ser80Asn Uncertain significance Single submitter
- BICRAL p.Ser947Leu Uncertain significance Single submitter
- BICRAL p.Thr162Met Uncertain significance Single submitter
- BICRAL p.Thr259Ser Uncertain significance Single submitter
- BICRAL p.Thr279Ser Uncertain significance Single submitter
- BICRAL p.Thr507Asn Uncertain significance Single submitter
- BICRAL p.Tyr326His Uncertain significance Single submitter
- BICRAL p.Tyr458His Uncertain significance Single submitter
- BICRAL p.Val173Ala Uncertain significance Single submitter
- BICRAL p.Val249Met Uncertain significance Single submitter
- BICRAL p.Val361Met Uncertain significance Single submitter
- BICRAL p.Val417Ile Uncertain significance Single submitter
- BICRAL p.Val417Phe Uncertain significance Single submitter
- BICRAL p.Val518Ile Uncertain significance Single submitter
- BICRAL p.Val672Ala Uncertain significance Single submitter
- BICRAL p.Val815Ile Uncertain significance Single submitter
-
BICRAL p.Lys593Arg
Uncertain significance
No assertion criteria
prostate cancer
Predictors split 29
The independent predictors disagree with each other — read with care.
- BICRAL p.Ala729Val Uncertain significance Single submitter
- BICRAL p.Arg841Trp Uncertain significance Single submitter
- BICRAL p.Arg924Trp Uncertain significance Single submitter
- BICRAL p.Arg941Trp Uncertain significance Single submitter
- BICRAL p.Asn412Asp Uncertain significance Single submitter
- BICRAL p.Asn772Lys Uncertain significance Single submitter
- BICRAL p.Cys776Phe Uncertain significance Single submitter
- BICRAL p.Gln712Arg Uncertain significance Single submitter
- BICRAL p.Gly211Arg Uncertain significance Single submitter
- BICRAL p.His186Leu Uncertain significance Single submitter
- BICRAL p.His963Tyr Uncertain significance Single submitter
- BICRAL p.Leu463Arg Uncertain significance Single submitter
- BICRAL p.Leu771Phe Uncertain significance Single submitter
- BICRAL p.Leu94Ile Uncertain significance Single submitter
- BICRAL p.Lys655Glu Uncertain significance Single submitter
- BICRAL p.Lys765Arg Uncertain significance Single submitter
- BICRAL p.Met791Val Uncertain significance Single submitter
- BICRAL p.Pro817Thr Uncertain significance Single submitter
- BICRAL p.Ser1006Gly Uncertain significance Single submitter
- BICRAL p.Ser434Cys Uncertain significance Single submitter
- BICRAL p.Ser592Phe Uncertain significance Single submitter
- BICRAL p.Ser60Pro Uncertain significance Single submitter
- BICRAL p.Ser851Arg Uncertain significance Single submitter
- BICRAL p.Ser918Cys Uncertain significance Single submitter
- BICRAL p.Thr645Ile Uncertain significance Single submitter
- BICRAL p.Thr870Met Uncertain significance Single submitter
- BICRAL p.Thr917Met Uncertain significance Single submitter
- BICRAL p.Thr967Met Uncertain significance Single submitter
- BICRAL p.Val192Ala Uncertain significance Single submitter
All BICRAL variants
Likely benign 4
- p.Ala396Thr Single submitter
- p.Ala526Thr Single submitter
- p.Asn66Ser Single submitter
- p.Gly868Ser Single submitter
Uncertain significance 136
- p.Ala42Val Single submitter ⚠
- p.Ala479Gly Single submitter ⚠
- p.Ala546Gly Single submitter ⚠
- p.Ala695Val Single submitter ⚠
- p.Ala729Val Single submitter ⚠
- p.Ala833Asp Single submitter ⚠
- p.Ala889Thr Single submitter ⚠
- p.Arg1022Gln Single submitter ⚠
- p.Arg586Cys Single submitter ⚠
- p.Arg724Gln Single submitter ⚠
- p.Arg808Gln Single submitter ⚠
- p.Arg811His Single submitter ⚠
- p.Arg841Gln Single submitter ⚠
- p.Arg841Trp Single submitter ⚠
- p.Arg864Gln Single submitter ⚠
- p.Arg902Thr Single submitter ⚠
- p.Arg924Trp Single submitter ⚠
- p.Arg941Gln Single submitter ⚠
- p.Arg941Trp Single submitter ⚠
- p.Arg946Ser Single submitter ⚠
- p.Arg978Gly Single submitter ⚠
- p.Asn263Ser Single submitter ⚠
- p.Asn330Ser Single submitter ⚠
- p.Asn412Asp Single submitter ⚠
- p.Asn44Ser Single submitter ⚠
- p.Asn51Ser Single submitter ⚠
- p.Asn54Ser Single submitter ⚠
- p.Asn772Lys Single submitter ⚠
- p.Asn786Ser Single submitter ⚠
- p.Asp795Asn Single submitter ⚠
- p.Cys776Phe Single submitter ⚠
- p.Cys899Tyr Single submitter ⚠
- p.Gln323Arg Single submitter ⚠
- p.Gln503Pro Single submitter ⚠
- p.Gln712Arg Single submitter ⚠
- p.Gln83Arg Single submitter ⚠
- p.Gln877Arg Single submitter ⚠
- p.Gln913Arg Single submitter ⚠
- p.Glu90Lys Single submitter ⚠
- p.Glu938Lys Single submitter ⚠
- p.Glu952Gly Single submitter ⚠
- p.Glu996Lys Single submitter ⚠
- p.Gly1032Ser Single submitter ⚠
- p.Gly211Arg Single submitter ⚠
- p.Gly341Ala Single submitter ⚠
- p.Gly392Ser Single submitter ⚠
- p.Gly39Val Single submitter ⚠
- p.Gly497Arg Single submitter ⚠
- p.Gly633Asp Single submitter ⚠
- p.Gly641Arg Single submitter ⚠
- p.Gly673Glu Single submitter ⚠
- p.Gly688Arg Single submitter ⚠
- p.Gly936Asp Single submitter ⚠
- p.His142Tyr Single submitter ⚠
- p.His186Leu Single submitter ⚠
- p.His845Leu Single submitter ⚠
- p.His879Arg Single submitter ⚠
- p.His940Leu Single submitter ⚠
- p.His963Tyr Single submitter ⚠
- p.Ile130Met Single submitter ⚠
- p.Ile130Val Single submitter ⚠
- p.Ile166Thr Single submitter ⚠
- p.Ile194fs Single submitter autism spectrum disorder
- p.Ile228Val Single submitter ⚠
- p.Ile237Val Single submitter ⚠
- p.Ile342Phe Single submitter ⚠
- p.Ile363Val Single submitter ⚠
- p.Ile48Val Single submitter ⚠
- p.Ile639Val Single submitter ⚠
- p.Leu1001Ile Single submitter ⚠
- p.Leu291Val Single submitter ⚠
- p.Leu463Arg Single submitter ⚠
- p.Leu494Phe Single submitter ⚠
- p.Leu571Pro Single submitter ⚠
- p.Leu771Phe Single submitter ⚠
- p.Leu94Ile Single submitter ⚠
- p.Leu986Ser Single submitter ⚠
- p.Lys1005Glu Single submitter ⚠
- p.Lys1012Arg Single submitter ⚠
- p.Lys655Glu Single submitter ⚠
- p.Lys700Glu Single submitter ⚠
- p.Lys765Arg Single submitter ⚠
- p.Lys895Glu Single submitter ⚠
- p.Lys896Glu Single submitter ⚠
- p.Lys929Glu Single submitter ⚠
- p.Lys954Arg Single submitter ⚠
- p.Met791Val Single submitter ⚠
- p.Met873Arg Single submitter ⚠
- p.Met991Thr Single submitter ⚠
- p.Phe598Ser Single submitter ⚠
- p.Phe723Leu Single submitter ⚠
- p.Pro1056Leu Single submitter ⚠
- p.Pro429Ala Single submitter ⚠
- p.Pro461Leu Single submitter ⚠
- p.Pro484Ser Single submitter ⚠
- p.Pro551Ala Single submitter ⚠
- p.Pro648Ser Single submitter ⚠
- p.Pro676Ser Single submitter ⚠
- p.Pro679Ser Single submitter ⚠
- p.Pro817Thr Single submitter ⚠
- p.Pro855Gln Single submitter ⚠
- p.Pro937Leu Single submitter ⚠
- p.Pro999Ser Single submitter ⚠
- p.Ser1006Gly Single submitter ⚠
- p.Ser129Asn Single submitter ⚠
- p.Ser241Gly Single submitter ⚠
- p.Ser269Ala Single submitter ⚠
- p.Ser434Cys Single submitter ⚠
- p.Ser512Pro Single submitter ⚠
- p.Ser552Ile Single submitter ⚠
- p.Ser592Phe Single submitter ⚠
- p.Ser60Pro Single submitter ⚠
- p.Ser80Asn Single submitter ⚠
- p.Ser851Arg Single submitter ⚠
- p.Ser918Cys Single submitter ⚠
- p.Ser947Leu Single submitter ⚠
- p.Thr162Met Single submitter ⚠
- p.Thr259Ser Single submitter ⚠
- p.Thr279Ser Single submitter ⚠
- p.Thr507Asn Single submitter ⚠
- p.Thr645Ile Single submitter ⚠
- p.Thr870Met Single submitter ⚠
- p.Thr917Met Single submitter ⚠
- p.Thr967Met Single submitter ⚠
- p.Tyr326His Single submitter ⚠
- p.Tyr458His Single submitter ⚠
- p.Val173Ala Single submitter ⚠
- p.Val192Ala Single submitter ⚠
- p.Val249Met Single submitter ⚠
- p.Val361Met Single submitter ⚠
- p.Val417Ile Single submitter ⚠
- p.Val417Phe Single submitter ⚠
- p.Val518Ile Single submitter ⚠
- p.Val672Ala Single submitter ⚠
- p.Val815Ile Single submitter ⚠
- p.Lys593Arg No assertion criteria prostate cancer ⚠