BIN2 — 64 ClinVar variants
All ClinVar germline BIN2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 58 flagged for review →
8 Likely benign · 56 Uncertain significance
Full BIN2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 58
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 30
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- BIN2 p.Ala344Val Uncertain significance Single submitter
- BIN2 p.Ala384Thr Uncertain significance Single submitter
- BIN2 p.Arg138Thr Uncertain significance Single submitter
- BIN2 p.Arg142Trp Uncertain significance Single submitter
- BIN2 p.Arg202Cys Uncertain significance Single submitter
- BIN2 p.Arg202His Uncertain significance Single submitter
- BIN2 p.Arg404Thr Uncertain significance Single submitter
- BIN2 p.Arg42Leu Uncertain significance Single submitter
- BIN2 p.Glu185Gly Uncertain significance Single submitter
- BIN2 p.Glu353Lys Uncertain significance Single submitter
- BIN2 p.Glu483Asp Uncertain significance Single submitter
- BIN2 p.Glu552Val Uncertain significance Single submitter
- BIN2 p.Gly33Arg Uncertain significance Single submitter
- BIN2 p.Gly4Ser Uncertain significance Single submitter
- BIN2 p.Gly511Arg Uncertain significance Single submitter
- BIN2 p.Gly95Asp Uncertain significance Single submitter
- BIN2 p.Leu284Arg Uncertain significance Single submitter
- BIN2 p.Leu452Ser Uncertain significance Single submitter
- BIN2 p.Leu565Pro Uncertain significance Single submitter
- BIN2 p.Phe247Ser Uncertain significance Single submitter
- BIN2 p.Pro301Thr Uncertain significance Single submitter
- BIN2 p.Pro350Ala Uncertain significance Single submitter
- BIN2 p.Ser326Pro Uncertain significance Single submitter
- BIN2 p.Ser369Thr Uncertain significance Single submitter
- BIN2 p.Thr351Ala Uncertain significance Single submitter
- BIN2 p.Thr391Ala Uncertain significance Single submitter
- BIN2 p.Thr478Ile Uncertain significance Single submitter
- BIN2 p.Thr503Ser Uncertain significance Single submitter
- BIN2 p.Tyr206Cys Uncertain significance Single submitter
- BIN2 p.Val476Leu Uncertain significance Single submitter
Predictors split 28
The independent predictors disagree with each other — read with care.
- BIN2 p.Ala121Val Uncertain significance Single submitter
- BIN2 p.Ala130Thr Uncertain significance Single submitter
- BIN2 p.Ala158Thr Uncertain significance Single submitter
- BIN2 p.Arg123Lys Uncertain significance Single submitter
- BIN2 p.Arg392His Uncertain significance Single submitter
- BIN2 p.Asn244Tyr Uncertain significance Single submitter
- BIN2 p.Asn49Lys Uncertain significance Single submitter
- BIN2 p.Glu114Lys Uncertain significance Single submitter
- BIN2 p.Glu320Gln Uncertain significance Single submitter
- BIN2 p.Glu517Lys Uncertain significance Single submitter
- BIN2 p.Gly95Ser Uncertain significance Single submitter
- BIN2 p.His488Tyr Uncertain significance Single submitter
- BIN2 p.Leu198Ile Uncertain significance Single submitter
- BIN2 p.Leu198Phe Uncertain significance Single submitter
- BIN2 p.Met74Val Uncertain significance Single submitter
- BIN2 p.Pro459Ser Uncertain significance Single submitter
- BIN2 p.Ser280Cys Uncertain significance Single submitter
- BIN2 p.Ser280Gly Uncertain significance Single submitter
- BIN2 p.Ser375Ile Likely benign Single submitter
- BIN2 p.Ser395Asn Uncertain significance Single submitter
- BIN2 p.Ser415Asn Likely benign Single submitter
- BIN2 p.Ser415Gly Uncertain significance Single submitter
- BIN2 p.Ser436Gly Uncertain significance Single submitter
- BIN2 p.Ser444Leu Uncertain significance Single submitter
- BIN2 p.Ser91Arg Uncertain significance Single submitter
- BIN2 p.Thr276Ile Uncertain significance Single submitter
- BIN2 p.Thr279Pro Uncertain significance Single submitter
- BIN2 p.Val465Asp Uncertain significance Single submitter
All BIN2 variants
Likely benign 8
- p.Ala344Thr Single submitter
- p.Gly372Arg Single submitter
- p.Leu548Val Single submitter
- p.Ser375Ile Single submitter ⚠
- p.Ser415Asn Single submitter ⚠
- p.Thr367Ala Single submitter
- p.Thr385Ala Single submitter
- p.Val293Ile Single submitter
Uncertain significance 56
- p.Ala121Val Single submitter ⚠
- p.Ala130Thr Single submitter ⚠
- p.Ala158Thr Single submitter ⚠
- p.Ala344Val Single submitter ⚠
- p.Ala384Thr Single submitter ⚠
- p.Arg123Lys Single submitter ⚠
- p.Arg138Thr Single submitter ⚠
- p.Arg142Trp Single submitter ⚠
- p.Arg202Cys Single submitter ⚠
- p.Arg202His Single submitter ⚠
- p.Arg392His Single submitter ⚠
- p.Arg404Thr Single submitter ⚠
- p.Arg42Leu Single submitter ⚠
- p.Asn244Tyr Single submitter ⚠
- p.Asn49Lys Single submitter ⚠
- p.Glu114Lys Single submitter ⚠
- p.Glu185Gly Single submitter ⚠
- p.Glu320Gln Single submitter ⚠
- p.Glu353Lys Single submitter ⚠
- p.Glu483Asp Single submitter ⚠
- p.Glu517Lys Single submitter ⚠
- p.Glu552Val Single submitter ⚠
- p.Gly33Arg Single submitter ⚠
- p.Gly4Ser Single submitter ⚠
- p.Gly511Arg Single submitter ⚠
- p.Gly95Asp Single submitter ⚠
- p.Gly95Ser Single submitter ⚠
- p.His488Tyr Single submitter ⚠
- p.Leu198Ile Single submitter ⚠
- p.Leu198Phe Single submitter ⚠
- p.Leu284Arg Single submitter ⚠
- p.Leu452Ser Single submitter ⚠
- p.Leu565Pro Single submitter ⚠
- p.Met74Val Single submitter ⚠
- p.Phe247Ser Single submitter ⚠
- p.Pro301Thr Single submitter ⚠
- p.Pro350Ala Single submitter ⚠
- p.Pro459Ser Single submitter ⚠
- p.Ser280Cys Single submitter ⚠
- p.Ser280Gly Single submitter ⚠
- p.Ser326Pro Single submitter ⚠
- p.Ser369Thr Single submitter ⚠
- p.Ser395Asn Single submitter ⚠
- p.Ser415Gly Single submitter ⚠
- p.Ser436Gly Single submitter ⚠
- p.Ser444Leu Single submitter ⚠
- p.Ser91Arg Single submitter ⚠
- p.Thr276Ile Single submitter ⚠
- p.Thr279Pro Single submitter ⚠
- p.Thr351Ala Single submitter ⚠
- p.Thr391Ala Single submitter ⚠
- p.Thr478Ile Single submitter ⚠
- p.Thr503Ser Single submitter ⚠
- p.Tyr206Cys Single submitter ⚠
- p.Val465Asp Single submitter ⚠
- p.Val476Leu Single submitter ⚠