BIN3 — 71 ClinVar variants
All ClinVar germline BIN3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 68 flagged for review →
1 Benign · 2 Likely benign · 68 Uncertain significance
Full BIN3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 68
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 32
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- BIN3 p.Ala131Pro Uncertain significance Single submitter
- BIN3 p.Arg128Gln Uncertain significance Single submitter
- BIN3 p.Arg128Trp Uncertain significance Single submitter
- BIN3 p.Arg166Gln Uncertain significance Single submitter
- BIN3 p.Arg203Gln Uncertain significance Single submitter
- BIN3 p.Arg235Gln Uncertain significance Single submitter
- BIN3 p.Arg245Trp Uncertain significance Single submitter
- BIN3 p.Asn101Asp Uncertain significance Single submitter
- BIN3 p.Asn69Ser Uncertain significance Single submitter
- BIN3 p.Asn96Ser Uncertain significance Single submitter
- BIN3 p.Asp134Gly Uncertain significance Single submitter
- BIN3 p.Asp192Glu Uncertain significance Single submitter
- BIN3 p.Gln104Arg Uncertain significance Single submitter
- BIN3 p.Gln37His Uncertain significance Single submitter
- BIN3 p.Gly115Ser Uncertain significance Single submitter
- BIN3 p.Gly188Ser Uncertain significance Single submitter
- BIN3 p.His159Gln Uncertain significance Single submitter
- BIN3 p.His221Arg Uncertain significance Single submitter
- BIN3 p.Ile4Met Uncertain significance Single submitter
- BIN3 p.Ile62Leu Uncertain significance Single submitter
- BIN3 p.Ile8Thr Uncertain significance Single submitter
- BIN3 p.Leu223Val Uncertain significance Single submitter
- BIN3 p.Leu31Pro Uncertain significance Single submitter
- BIN3 p.Met89Val Uncertain significance Single submitter
- BIN3 p.Pro184Leu Uncertain significance Single submitter
- BIN3 p.Pro196Leu Uncertain significance Single submitter
- BIN3 p.Pro70Ser Uncertain significance Single submitter
- BIN3 p.Ser220Phe Uncertain significance Single submitter
- BIN3 p.Ser242Gly Uncertain significance Single submitter
- BIN3 p.Ser56Leu Uncertain significance Single submitter
- BIN3 p.Thr19Ile Uncertain significance Single submitter
- BIN3 p.Val60Met Uncertain significance Single submitter
Predictors split 36
The independent predictors disagree with each other — read with care.
- BIN3 p.Arg136Gly Uncertain significance Single submitter
- BIN3 p.Arg185Cys Uncertain significance Single submitter
- BIN3 p.Arg233Trp Uncertain significance Single submitter
- BIN3 p.Arg91Pro Uncertain significance Single submitter
- BIN3 p.Asn122Ser Uncertain significance Single submitter
- BIN3 p.Asp192Tyr Uncertain significance Single submitter
- BIN3 p.Asp230Asn Uncertain significance Single submitter
- BIN3 p.Asp252Asn Uncertain significance Single submitter
- BIN3 p.Asp44Glu Uncertain significance Single submitter
- BIN3 p.Asp50Asn Uncertain significance Single submitter
- BIN3 p.Cys72Tyr Uncertain significance Single submitter
- BIN3 p.Gln178His Uncertain significance Single submitter
- BIN3 p.Gln42Arg Uncertain significance Single submitter
- BIN3 p.Glu163Lys Uncertain significance Single submitter
- BIN3 p.Glu170Lys Uncertain significance Single submitter
- BIN3 p.Glu181Lys Uncertain significance Single submitter
- BIN3 p.Glu199Lys Uncertain significance Single submitter
- BIN3 p.Glu238Lys Uncertain significance Single submitter
- BIN3 p.Gly29Glu Uncertain significance Single submitter
- BIN3 p.Ile108Met Uncertain significance Single submitter
- BIN3 p.Leu121Phe Uncertain significance Single submitter
- BIN3 p.Leu241Val Uncertain significance Single submitter
- BIN3 p.Leu247Phe Uncertain significance Single submitter
- BIN3 p.Met183Ile Uncertain significance Single submitter
- BIN3 p.Met92Ile Uncertain significance Single submitter
- BIN3 p.Pro153Leu Uncertain significance Single submitter
- BIN3 p.Pro167Ala Uncertain significance Single submitter
- BIN3 p.Pro226Leu Uncertain significance Single submitter
- BIN3 p.Ser116Arg Uncertain significance Single submitter
- BIN3 p.Ser210Leu Uncertain significance Single submitter
- BIN3 p.Ser229Phe Uncertain significance Single submitter
- BIN3 p.Ser229Tyr Uncertain significance Single submitter
- BIN3 p.Ser2Cys Uncertain significance Single submitter
- BIN3 p.Ser68Phe Uncertain significance Single submitter
- BIN3 p.Thr151Met Uncertain significance Single submitter
- BIN3 p.Thr83Met Uncertain significance Single submitter
All BIN3 variants
Benign 1
- c.297+5C>T Multiple submitters
Likely benign 2
- p.Asn80Ser Single submitter
- p.Ser229= Single submitter
Uncertain significance 68
- p.Ala131Pro Single submitter ⚠
- p.Arg128Gln Single submitter ⚠
- p.Arg128Trp Single submitter ⚠
- p.Arg136Gly Single submitter ⚠
- p.Arg166Gln Single submitter ⚠
- p.Arg185Cys Single submitter ⚠
- p.Arg203Gln Single submitter ⚠
- p.Arg233Trp Single submitter ⚠
- p.Arg235Gln Single submitter ⚠
- p.Arg245Trp Single submitter ⚠
- p.Arg91Pro Single submitter ⚠
- p.Asn101Asp Single submitter ⚠
- p.Asn122Ser Single submitter ⚠
- p.Asn69Ser Single submitter ⚠
- p.Asn96Ser Single submitter ⚠
- p.Asp134Gly Single submitter ⚠
- p.Asp192Glu Single submitter ⚠
- p.Asp192Tyr Single submitter ⚠
- p.Asp230Asn Single submitter ⚠
- p.Asp252Asn Single submitter ⚠
- p.Asp44Glu Single submitter ⚠
- p.Asp50Asn Single submitter ⚠
- p.Cys72Tyr Single submitter ⚠
- p.Gln104Arg Single submitter ⚠
- p.Gln178His Single submitter ⚠
- p.Gln37His Single submitter ⚠
- p.Gln42Arg Single submitter ⚠
- p.Glu163Lys Single submitter ⚠
- p.Glu170Lys Single submitter ⚠
- p.Glu181Lys Single submitter ⚠
- p.Glu199Lys Single submitter ⚠
- p.Glu238Lys Single submitter ⚠
- p.Gly115Ser Single submitter ⚠
- p.Gly188Ser Single submitter ⚠
- p.Gly29Glu Single submitter ⚠
- p.His159Gln Single submitter ⚠
- p.His221Arg Single submitter ⚠
- p.Ile108Met Single submitter ⚠
- p.Ile4Met Single submitter ⚠
- p.Ile62Leu Single submitter ⚠
- p.Ile8Thr Single submitter ⚠
- p.Leu121Phe Single submitter ⚠
- p.Leu223Val Single submitter ⚠
- p.Leu241Val Single submitter ⚠
- p.Leu247Phe Single submitter ⚠
- p.Leu31Pro Single submitter ⚠
- p.Met183Ile Single submitter ⚠
- p.Met89Val Single submitter ⚠
- p.Met92Ile Single submitter ⚠
- p.Pro153Leu Single submitter ⚠
- p.Pro167Ala Single submitter ⚠
- p.Pro184Leu Single submitter ⚠
- p.Pro196Leu Single submitter ⚠
- p.Pro226Leu Single submitter ⚠
- p.Pro70Ser Single submitter ⚠
- p.Ser116Arg Single submitter ⚠
- p.Ser210Leu Single submitter ⚠
- p.Ser220Phe Single submitter ⚠
- p.Ser229Phe Single submitter ⚠
- p.Ser229Tyr Single submitter ⚠
- p.Ser242Gly Single submitter ⚠
- p.Ser2Cys Single submitter ⚠
- p.Ser56Leu Single submitter ⚠
- p.Ser68Phe Single submitter ⚠
- p.Thr151Met Single submitter ⚠
- p.Thr19Ile Single submitter ⚠
- p.Thr83Met Single submitter ⚠
- p.Val60Met Single submitter ⚠