BIRC2 — 84 ClinVar variants
All ClinVar germline BIRC2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 80 flagged for review →
1 Benign · 4 Likely benign · 79 Uncertain significance
Full BIRC2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 80
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 44
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- BIRC2 p.Ala388Thr Uncertain significance Single submitter
- BIRC2 p.Ala58Ser Uncertain significance Single submitter
- BIRC2 p.Arg164Lys Uncertain significance Single submitter
- BIRC2 p.Arg338Gln Uncertain significance Single submitter
- BIRC2 p.Arg462Gln Uncertain significance Single submitter
- BIRC2 p.Arg462Trp Uncertain significance Single submitter
- BIRC2 p.Asn127Tyr Uncertain significance Single submitter
- BIRC2 p.Asn162Lys Uncertain significance Single submitter
- BIRC2 p.Asn175Lys Uncertain significance Single submitter
- BIRC2 p.Asn486Ser Uncertain significance Single submitter
- BIRC2 p.Asp168Gly Uncertain significance Single submitter
- BIRC2 p.Asp234His Uncertain significance Single submitter
- BIRC2 p.Asp235Val Uncertain significance Single submitter
- BIRC2 p.Cys83Ser Uncertain significance Single submitter
- BIRC2 p.Gln37Pro Uncertain significance Single submitter
- BIRC2 p.Gly611Ala Uncertain significance Single submitter
- BIRC2 p.His103Tyr Uncertain significance Single submitter
- BIRC2 p.His2Gln Uncertain significance Single submitter
- BIRC2 p.Ile18Val Uncertain significance Single submitter
- BIRC2 p.Ile212Val Uncertain significance Single submitter
- BIRC2 p.Ile376Thr Uncertain significance Single submitter
- BIRC2 p.Ile604Val Uncertain significance Single submitter
- BIRC2 p.Leu139Phe Uncertain significance Single submitter
- BIRC2 p.Leu161Ile Uncertain significance Single submitter
- BIRC2 p.Leu254Pro Uncertain significance Single submitter
- BIRC2 p.Leu418Val Uncertain significance Single submitter
- BIRC2 p.Lys499Arg Uncertain significance Single submitter
- BIRC2 p.Lys577Arg Uncertain significance Single submitter
- BIRC2 p.Met181Thr Uncertain significance Single submitter
- BIRC2 p.Met193Ile Uncertain significance Single submitter
- BIRC2 p.Met453Ile Uncertain significance Single submitter
- BIRC2 p.Phe43Leu Uncertain significance Single submitter
- BIRC2 p.Pro284Ser Uncertain significance Single submitter
- BIRC2 p.Pro549Ser Uncertain significance Single submitter
- BIRC2 p.Pro585Leu Uncertain significance Single submitter
- BIRC2 p.Ser14Ala Uncertain significance Single submitter
- BIRC2 p.Ser14Leu Uncertain significance Single submitter
- BIRC2 p.Ser171Leu Uncertain significance Single submitter
- BIRC2 p.Ser265Thr Uncertain significance Single submitter
- BIRC2 p.Thr142Ile Uncertain significance Single submitter
- BIRC2 p.Thr32Ala Uncertain significance Single submitter
- BIRC2 p.Thr366Ser Uncertain significance Single submitter
- BIRC2 p.Val389Phe Uncertain significance Single submitter
- BIRC2 p.Val487Ile Uncertain significance Single submitter
Predictors split 36
The independent predictors disagree with each other — read with care.
- BIRC2 p.Ala186Thr Uncertain significance Single submitter
- BIRC2 p.Arg241Gln Uncertain significance Single submitter
- BIRC2 p.Arg300Cys Uncertain significance Single submitter
- BIRC2 p.Arg338Gly Uncertain significance Single submitter
- BIRC2 p.Arg569Gln Uncertain significance Single submitter
- BIRC2 p.Arg69His Uncertain significance Single submitter
- BIRC2 p.Asn115His Uncertain significance Single submitter
- BIRC2 p.Asp321Asn Uncertain significance Single submitter
- BIRC2 p.Asp532Asn Uncertain significance Single submitter
- BIRC2 p.Cys85Phe Uncertain significance Single submitter
- BIRC2 p.Gln505Glu Uncertain significance Single submitter
- BIRC2 p.Gln566His Uncertain significance Single submitter
- BIRC2 p.Glu343Gly Uncertain significance Single submitter
- BIRC2 p.Glu422Gly Uncertain significance Single submitter
- BIRC2 p.Glu438Lys Uncertain significance Single submitter
- BIRC2 p.Glu440Gly Uncertain significance Single submitter
- BIRC2 p.Leu196Val Uncertain significance Single submitter
- BIRC2 p.Leu435Ile Uncertain significance Single submitter
- BIRC2 p.Leu468Phe Uncertain significance Single submitter
- BIRC2 p.Leu476Phe Uncertain significance Single submitter
- BIRC2 p.Leu562Ser Uncertain significance Single submitter
- BIRC2 p.Lys82Arg Uncertain significance Single submitter
- BIRC2 p.Met181Lys Uncertain significance Single submitter
- BIRC2 p.Met266Val Uncertain significance Single submitter
- BIRC2 p.Pro245Ala Uncertain significance Single submitter
- BIRC2 p.Ser111Gly Uncertain significance Single submitter
- BIRC2 p.Ser134Gly Uncertain significance Single submitter
- BIRC2 p.Ser533Cys Uncertain significance Single submitter
- BIRC2 p.Ser557Leu Uncertain significance Single submitter
- BIRC2 p.Thr26Met Uncertain significance Single submitter
- BIRC2 p.Thr55Pro Uncertain significance Single submitter
- BIRC2 p.Tyr177Cys Uncertain significance Single submitter
- BIRC2 p.Val218Ile Uncertain significance Single submitter
- BIRC2 p.Val487Ala Uncertain significance Single submitter
- BIRC2 p.Val590Ile Uncertain significance Single submitter
-
BIRC2 p.Lys516Glu
Likely benign
No assertion criteria
BIRC2-related disorder
All BIRC2 variants
Benign 1
- p.Ala506Val Multiple submitters
Likely benign 4
- p.Ala5Thr Single submitter
- p.Leu139= Single submitter
- p.Thr55Ala Single submitter
- p.Lys516Glu No assertion criteria BIRC2-related disorder ⚠
Uncertain significance 79
- p.Ala186Thr Single submitter ⚠
- p.Ala388Thr Single submitter ⚠
- p.Ala58Ser Single submitter ⚠
- p.Arg164Lys Single submitter ⚠
- p.Arg241Gln Single submitter ⚠
- p.Arg300Cys Single submitter ⚠
- p.Arg338Gln Single submitter ⚠
- p.Arg338Gly Single submitter ⚠
- p.Arg462Gln Single submitter ⚠
- p.Arg462Trp Single submitter ⚠
- p.Arg569Gln Single submitter ⚠
- p.Arg69His Single submitter ⚠
- p.Asn115His Single submitter ⚠
- p.Asn127Tyr Single submitter ⚠
- p.Asn162Lys Single submitter ⚠
- p.Asn175Lys Single submitter ⚠
- p.Asn486Ser Single submitter ⚠
- p.Asp168Gly Single submitter ⚠
- p.Asp234His Single submitter ⚠
- p.Asp235Val Single submitter ⚠
- p.Asp321Asn Single submitter ⚠
- p.Asp532Asn Single submitter ⚠
- p.Cys83Ser Single submitter ⚠
- p.Cys85Phe Single submitter ⚠
- p.Gln37Pro Single submitter ⚠
- p.Gln505Glu Single submitter ⚠
- p.Gln566His Single submitter ⚠
- p.Glu343Gly Single submitter ⚠
- p.Glu422Gly Single submitter ⚠
- p.Glu438Lys Single submitter ⚠
- p.Glu440Gly Single submitter ⚠
- p.Gly611Ala Single submitter ⚠
- p.His103Tyr Single submitter ⚠
- p.His2Gln Single submitter ⚠
- p.Ile18Val Single submitter ⚠
- p.Ile212Val Single submitter ⚠
- p.Ile376Thr Single submitter ⚠
- p.Ile604Val Single submitter ⚠
- p.Leu139Phe Single submitter ⚠
- p.Leu161Ile Single submitter ⚠
- p.Leu196Val Single submitter ⚠
- p.Leu254Pro Single submitter ⚠
- p.Leu418Val Single submitter ⚠
- p.Leu435Ile Single submitter ⚠
- p.Leu468Phe Single submitter ⚠
- p.Leu476Phe Single submitter ⚠
- p.Leu562Ser Single submitter ⚠
- p.Lys499Arg Single submitter ⚠
- p.Lys577Arg Single submitter ⚠
- p.Lys82Arg Single submitter ⚠
- p.Met181Lys Single submitter ⚠
- p.Met181Thr Single submitter ⚠
- p.Met193Ile Single submitter ⚠
- p.Met266Val Single submitter ⚠
- p.Met453Ile Single submitter ⚠
- p.Phe43Leu Single submitter ⚠
- p.Pro245Ala Single submitter ⚠
- p.Pro284Ser Single submitter ⚠
- p.Pro549Ser Single submitter ⚠
- p.Pro585Leu Single submitter ⚠
- p.Ser111Gly Single submitter ⚠
- p.Ser134Gly Single submitter ⚠
- p.Ser14Ala Single submitter ⚠
- p.Ser14Leu Single submitter ⚠
- p.Ser171Leu Single submitter ⚠
- p.Ser265Thr Single submitter ⚠
- p.Ser533Cys Single submitter ⚠
- p.Ser557Leu Single submitter ⚠
- p.Thr142Ile Single submitter ⚠
- p.Thr26Met Single submitter ⚠
- p.Thr32Ala Single submitter ⚠
- p.Thr366Ser Single submitter ⚠
- p.Thr55Pro Single submitter ⚠
- p.Tyr177Cys Single submitter ⚠
- p.Val218Ile Single submitter ⚠
- p.Val389Phe Single submitter ⚠
- p.Val487Ala Single submitter ⚠
- p.Val487Ile Single submitter ⚠
- p.Val590Ile Single submitter ⚠