BLVRB — 51 ClinVar variants
All ClinVar germline BLVRB variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 44 flagged for review →
1 Benign · 6 Likely benign · 44 Uncertain significance
Full BLVRB gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 44
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 18
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- BLVRB p.Ala21Thr Uncertain significance Single submitter
- BLVRB p.Ala91Thr Uncertain significance Single submitter
- BLVRB p.Arg134Gln Uncertain significance Single submitter
- BLVRB p.Arg174Lys Uncertain significance Single submitter
- BLVRB p.Arg35Trp Uncertain significance Single submitter
- BLVRB p.Arg78His Uncertain significance Single submitter
- BLVRB p.Asp195Asn Uncertain significance Single submitter
- BLVRB p.Gly10Arg Uncertain significance Single submitter
- BLVRB p.Gly16Arg Uncertain significance Single submitter
- BLVRB p.Gly90Ser Uncertain significance Single submitter
- BLVRB p.Ile94Thr Uncertain significance Single submitter
- BLVRB p.Leu114Pro Uncertain significance Single submitter
- BLVRB p.Lys120Glu Uncertain significance Single submitter
- BLVRB p.Met98Arg Uncertain significance Single submitter
- BLVRB p.Pro122Ser Uncertain significance Single submitter
- BLVRB p.Pro151Leu Uncertain significance Single submitter
- BLVRB p.Val107Gly Uncertain significance Single submitter
- BLVRB p.Val107Met Uncertain significance Single submitter
Predictors split 26
The independent predictors disagree with each other — read with care.
- BLVRB p.Ala162Val Uncertain significance Single submitter
- BLVRB p.Ala26Thr Uncertain significance Single submitter
- BLVRB p.Ala7Val Uncertain significance Single submitter
- BLVRB p.Arg174Ser Uncertain significance Single submitter
- BLVRB p.Arg187Cys Uncertain significance Single submitter
- BLVRB p.Arg92Trp Uncertain significance Single submitter
- BLVRB p.Asn79Lys Uncertain significance Single submitter
- BLVRB p.Asn93Ile Uncertain significance Single submitter
- BLVRB p.Asp60Asn Uncertain significance Single submitter
- BLVRB p.Gln22Arg Uncertain significance Single submitter
- BLVRB p.Glu141Ala Uncertain significance Single submitter
- BLVRB p.Glu193Asp Uncertain significance Single submitter
- BLVRB p.Glu89Lys Uncertain significance Single submitter
- BLVRB p.Gly143Asp Uncertain significance Single submitter
- BLVRB p.His101Arg Uncertain significance Single submitter
- BLVRB p.His179Arg Uncertain significance Single submitter
- BLVRB p.His49Asp Uncertain significance Single submitter
- BLVRB p.Ile176Val Uncertain significance Single submitter
- BLVRB p.Ile6Met Uncertain significance Single submitter
- BLVRB p.Lys145Gln Uncertain significance Single submitter
- BLVRB p.Pro47Leu Uncertain significance Single submitter
- BLVRB p.Ser198Arg Uncertain significance Single submitter
- BLVRB p.Thr31Arg Uncertain significance Single submitter
- BLVRB p.Val50Met Uncertain significance Single submitter
- BLVRB p.Val65Met Uncertain significance Single submitter
- BLVRB p.Val86Met Uncertain significance Single submitter
All BLVRB variants
Benign 1
- p.Thr84= Multiple submitters
Likely benign 6
- p.Arg140Gly Multiple submitters
- p.Arg46Gln Multiple submitters
- p.Arg187His Single submitter
- p.Arg92Gln Single submitter
- p.His49= Single submitter
- p.Ser198Asn Single submitter
Uncertain significance 44
- p.Ala162Val Single submitter ⚠
- p.Ala21Thr Single submitter ⚠
- p.Ala26Thr Single submitter ⚠
- p.Ala7Val Single submitter ⚠
- p.Ala91Thr Single submitter ⚠
- p.Arg134Gln Single submitter ⚠
- p.Arg174Lys Single submitter ⚠
- p.Arg174Ser Single submitter ⚠
- p.Arg187Cys Single submitter ⚠
- p.Arg35Trp Single submitter ⚠
- p.Arg78His Single submitter ⚠
- p.Arg92Trp Single submitter ⚠
- p.Asn79Lys Single submitter ⚠
- p.Asn93Ile Single submitter ⚠
- p.Asp195Asn Single submitter ⚠
- p.Asp60Asn Single submitter ⚠
- p.Gln22Arg Single submitter ⚠
- p.Glu141Ala Single submitter ⚠
- p.Glu193Asp Single submitter ⚠
- p.Glu89Lys Single submitter ⚠
- p.Gly10Arg Single submitter ⚠
- p.Gly143Asp Single submitter ⚠
- p.Gly16Arg Single submitter ⚠
- p.Gly90Ser Single submitter ⚠
- p.His101Arg Single submitter ⚠
- p.His179Arg Single submitter ⚠
- p.His49Asp Single submitter ⚠
- p.Ile176Val Single submitter ⚠
- p.Ile6Met Single submitter ⚠
- p.Ile94Thr Single submitter ⚠
- p.Leu114Pro Single submitter ⚠
- p.Lys120Glu Single submitter ⚠
- p.Lys145Gln Single submitter ⚠
- p.Met98Arg Single submitter ⚠
- p.Pro122Ser Single submitter ⚠
- p.Pro151Leu Single submitter ⚠
- p.Pro47Leu Single submitter ⚠
- p.Ser198Arg Single submitter ⚠
- p.Thr31Arg Single submitter ⚠
- p.Val107Gly Single submitter ⚠
- p.Val107Met Single submitter ⚠
- p.Val50Met Single submitter ⚠
- p.Val65Met Single submitter ⚠
- p.Val86Met Single submitter ⚠