BMP10 — 49 ClinVar variants
All ClinVar germline BMP10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 42 flagged for review →
1 Benign · 1 Benign/Likely benign · 6 Likely benign · 41 Uncertain significance
Full BMP10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 42
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 25
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- BMP10 p.Ala298Thr Uncertain significance Single submitter
- BMP10 p.Arg155His Uncertain significance Single submitter
- BMP10 p.Arg96Gln Uncertain significance Single submitter
- BMP10 p.Asn90Asp Uncertain significance Single submitter
- BMP10 p.Asp154Asn Uncertain significance Single submitter
- BMP10 p.Asp283Gly Uncertain significance Single submitter
- BMP10 p.Asp331Asn Uncertain significance Single submitter
- BMP10 p.Gln29Pro Uncertain significance Single submitter
- BMP10 p.Gln74Arg Uncertain significance Single submitter
- BMP10 p.Glu178Lys Uncertain significance Single submitter
- BMP10 p.Glu296Lys Uncertain significance Single submitter
- BMP10 p.Glu297Ala Uncertain significance Single submitter
- BMP10 p.Gly189Ala Uncertain significance Single submitter
- BMP10 p.Gly422Ala Uncertain significance Single submitter
- BMP10 p.His137Gln Uncertain significance Single submitter
- BMP10 p.Leu184Met Uncertain significance Single submitter
- BMP10 p.Met36Val Uncertain significance Single submitter
- BMP10 p.Pro31Leu Uncertain significance Single submitter
- BMP10 p.Ser289Asn Uncertain significance Single submitter
- BMP10 p.Thr217Ala Uncertain significance Single submitter
- BMP10 p.Thr408Ile Uncertain significance Single submitter
- BMP10 p.Thr94Arg Uncertain significance Single submitter
- BMP10 p.Thr97Ser Uncertain significance Single submitter
- BMP10 p.Val151Ala Uncertain significance Single submitter
- BMP10 p.Val5Leu Uncertain significance Single submitter
Predictors split 17
The independent predictors disagree with each other — read with care.
- BMP10 p.Arg155Cys Uncertain significance Single submitter
- BMP10 p.Arg163Trp Uncertain significance Single submitter
- BMP10 p.Arg209Cys Likely benign Single submitter
- BMP10 p.Arg96Trp Uncertain significance Single submitter
- BMP10 p.Glu225Asp Uncertain significance Single submitter
- BMP10 p.Glu348Val Uncertain significance Single submitter
- BMP10 p.Glu87Lys Uncertain significance Single submitter
- BMP10 p.His218Asn Uncertain significance Single submitter
- BMP10 p.His223Tyr Uncertain significance Single submitter
- BMP10 p.Ile224Thr Uncertain significance Single submitter
- BMP10 p.Leu68Phe Uncertain significance Single submitter
- BMP10 p.Leu86Trp Uncertain significance Single submitter
- BMP10 p.Lys393Gln Uncertain significance Single submitter
- BMP10 p.Phe411Leu Uncertain significance Single submitter
- BMP10 p.Pro127Leu Uncertain significance Single submitter
- BMP10 p.Ser188Phe Uncertain significance Single submitter
- BMP10 p.Val185Asp Uncertain significance Single submitter
All BMP10 variants
Benign 1
- p.Asn250Lys Multiple submitters
Benign/Likely benign 1
- p.Thr200Ser Multiple submitters bladder exstrophy-epispadias-cloacal exstrophy complex
Likely benign 6
- p.Arg209Cys Single submitter ⚠
- p.Asp60Asn Single submitter
- p.Gln246Arg Single submitter
- p.Ser275Ala Single submitter
- p.Thr73Met Single submitter
- p.Arg124Ter No assertion criteria EBV-positive nodal T- and NK-cell lymphoma
Uncertain significance 41
- p.Ala298Thr Single submitter ⚠
- p.Arg155Cys Single submitter ⚠
- p.Arg155His Single submitter ⚠
- p.Arg163Trp Single submitter ⚠
- p.Arg96Gln Single submitter ⚠
- p.Arg96Trp Single submitter ⚠
- p.Asn90Asp Single submitter ⚠
- p.Asp154Asn Single submitter ⚠
- p.Asp283Gly Single submitter ⚠
- p.Asp331Asn Single submitter ⚠
- p.Gln29Pro Single submitter ⚠
- p.Gln74Arg Single submitter ⚠
- p.Glu178Lys Single submitter ⚠
- p.Glu225Asp Single submitter ⚠
- p.Glu296Lys Single submitter ⚠
- p.Glu297Ala Single submitter ⚠
- p.Glu348Val Single submitter ⚠
- p.Glu87Lys Single submitter ⚠
- p.Gly189Ala Single submitter ⚠
- p.Gly422Ala Single submitter ⚠
- p.His137Gln Single submitter ⚠
- p.His218Asn Single submitter ⚠
- p.His223Tyr Single submitter ⚠
- p.Ile224Thr Single submitter ⚠
- p.Leu184Met Single submitter ⚠
- p.Leu68Phe Single submitter ⚠
- p.Leu86Trp Single submitter ⚠
- p.Lys393Gln Single submitter ⚠
- p.Met36Val Single submitter ⚠
- p.Phe411Leu Single submitter ⚠
- p.Pro127Leu Single submitter ⚠
- p.Pro31Leu Single submitter ⚠
- p.Ser188Phe Single submitter ⚠
- p.Ser289Asn Single submitter ⚠
- p.Thr217Ala Single submitter ⚠
- p.Thr408Ile Single submitter ⚠
- p.Thr94Arg Single submitter ⚠
- p.Thr97Ser Single submitter ⚠
- p.Val151Ala Single submitter ⚠
- p.Val185Asp Single submitter ⚠
- p.Val5Leu Single submitter ⚠