BMP3 — 75 ClinVar variants
All ClinVar germline BMP3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 71 flagged for review →
3 Benign · 1 Benign/Likely benign · 2 Likely benign · 69 Uncertain significance
Full BMP3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 71
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 51
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- BMP3 p.Ala156Val Uncertain significance Single submitter
- BMP3 p.Ala188Pro Uncertain significance Single submitter
- BMP3 p.Ala209Val Uncertain significance Single submitter
- BMP3 p.Ala248Ser Uncertain significance Single submitter
- BMP3 p.Ala248Thr Uncertain significance Single submitter
- BMP3 p.Ala305Glu Uncertain significance Single submitter
- BMP3 p.Ala396Thr Uncertain significance Single submitter
- BMP3 p.Arg232Lys Uncertain significance Single submitter
- BMP3 p.Arg263Trp Uncertain significance Single submitter
- BMP3 p.Arg285Gln Uncertain significance Single submitter
- BMP3 p.Arg368Gln Uncertain significance Single submitter
- BMP3 p.Arg372Gly Uncertain significance Single submitter
- BMP3 p.Arg66Ser Uncertain significance Single submitter
- BMP3 p.Arg87Leu Uncertain significance Single submitter
- BMP3 p.Arg89Gly Uncertain significance Single submitter
- BMP3 p.Arg98Cys Uncertain significance Single submitter
- BMP3 p.Asn126Ile Uncertain significance Single submitter
- BMP3 p.Asp378Val Uncertain significance Single submitter
- BMP3 p.Gln327Arg Uncertain significance Single submitter
- BMP3 p.Gln347Glu Uncertain significance Single submitter
- BMP3 p.Gly261Arg Uncertain significance Single submitter
- BMP3 p.Gly292Ala Uncertain significance Single submitter
- BMP3 p.Gly38Val Uncertain significance Single submitter
- BMP3 p.Gly431Arg Uncertain significance Single submitter
- BMP3 p.His182Arg Uncertain significance Single submitter
- BMP3 p.His262Asn Uncertain significance Single submitter
- BMP3 p.Ile382Thr Uncertain significance Single submitter
- BMP3 p.Ile389Thr Uncertain significance Single submitter
- BMP3 p.Leu302Ile Uncertain significance Single submitter
- BMP3 p.Leu324Phe Uncertain significance Single submitter
- BMP3 p.Lys319Glu Uncertain significance Single submitter
- BMP3 p.Lys322Arg Uncertain significance Single submitter
- BMP3 p.Lys459Glu Uncertain significance Single submitter
- BMP3 p.Lys55Asn Uncertain significance Single submitter
- BMP3 p.Phe449Leu Uncertain significance Single submitter
- BMP3 p.Pro238Thr Uncertain significance Single submitter
- BMP3 p.Pro25Arg Uncertain significance Single submitter
- BMP3 p.Pro30Gln Uncertain significance Single submitter
- BMP3 p.Pro320Ser Uncertain significance Single submitter
- BMP3 p.Pro76Leu Uncertain significance Single submitter
- BMP3 p.Ser153Ala Uncertain significance Single submitter
- BMP3 p.Ser153Pro Uncertain significance Single submitter
- BMP3 p.Ser446Asn Uncertain significance Single submitter
- BMP3 p.Thr169Ser Uncertain significance Single submitter
- BMP3 p.Trp168Cys Uncertain significance Single submitter
- BMP3 p.Tyr239Cys Uncertain significance Single submitter
- BMP3 p.Tyr398Cys Uncertain significance Single submitter
- BMP3 p.Val36Ala Uncertain significance Single submitter
- BMP3 p.Val36Leu Uncertain significance Single submitter
- BMP3 p.Val429Ile Uncertain significance Single submitter
- BMP3 p.Ala470Pro Uncertain significance No assertion criteria
Predictors split 20
The independent predictors disagree with each other — read with care.
- BMP3 p.Thr222Met Benign Multiple submitters
- BMP3 p.Ala20Glu Uncertain significance Single submitter
- BMP3 p.Ala359Thr Uncertain significance Single submitter
- BMP3 p.Ala470Thr Uncertain significance Single submitter
- BMP3 p.Arg24Ile Uncertain significance Single submitter
- BMP3 p.Arg40Cys Uncertain significance Single submitter
- BMP3 p.Arg40His Uncertain significance Single submitter
- BMP3 p.Arg89Trp Uncertain significance Single submitter
- BMP3 p.Gln363Leu Uncertain significance Single submitter
- BMP3 p.Glu214Gly Uncertain significance Single submitter
- BMP3 p.His191Leu Uncertain significance Single submitter
- BMP3 p.His59Tyr Uncertain significance Single submitter
- BMP3 p.Ile221Met Uncertain significance Single submitter
- BMP3 p.Ser173Ile Uncertain significance Single submitter
- BMP3 p.Ser290Thr Uncertain significance Single submitter
- BMP3 p.Ser332Cys Uncertain significance Single submitter
- BMP3 p.Ser346Cys Uncertain significance Single submitter
- BMP3 p.Thr107Ile Uncertain significance Single submitter
- BMP3 p.Thr222Ala Uncertain significance Single submitter
- BMP3 p.Thr348Met Benign Single submitter
All BMP3 variants
Benign 3
- p.Lys345Asn Multiple submitters
- p.Thr222Met Multiple submitters ⚠
- p.Thr348Met Single submitter ⚠
Benign/Likely benign 1
- p.Gln176Lys Multiple submitters
Likely benign 2
- p.Arg344Gln Single submitter
- p.Glu106Gly Single submitter
Uncertain significance 69
- p.Ala156Val Single submitter ⚠
- p.Ala188Pro Single submitter ⚠
- p.Ala209Val Single submitter ⚠
- p.Ala20Glu Single submitter ⚠
- p.Ala248Ser Single submitter ⚠
- p.Ala248Thr Single submitter ⚠
- p.Ala305Glu Single submitter ⚠
- p.Ala359Thr Single submitter ⚠
- p.Ala396Thr Single submitter ⚠
- p.Ala470Thr Single submitter ⚠
- p.Arg232Lys Single submitter ⚠
- p.Arg24Ile Single submitter ⚠
- p.Arg263Trp Single submitter ⚠
- p.Arg285Gln Single submitter ⚠
- p.Arg368Gln Single submitter ⚠
- p.Arg372Gly Single submitter ⚠
- p.Arg40Cys Single submitter ⚠
- p.Arg40His Single submitter ⚠
- p.Arg66Ser Single submitter ⚠
- p.Arg87Leu Single submitter ⚠
- p.Arg89Gly Single submitter ⚠
- p.Arg89Trp Single submitter ⚠
- p.Arg98Cys Single submitter ⚠
- p.Asn126Ile Single submitter ⚠
- p.Asp378Val Single submitter ⚠
- p.Gln327Arg Single submitter ⚠
- p.Gln347Glu Single submitter ⚠
- p.Gln363Leu Single submitter ⚠
- p.Glu214Gly Single submitter ⚠
- p.Gly261Arg Single submitter ⚠
- p.Gly292Ala Single submitter ⚠
- p.Gly38Val Single submitter ⚠
- p.Gly431Arg Single submitter ⚠
- p.His182Arg Single submitter ⚠
- p.His191Leu Single submitter ⚠
- p.His262Asn Single submitter ⚠
- p.His59Tyr Single submitter ⚠
- p.Ile221Met Single submitter ⚠
- p.Ile382Thr Single submitter ⚠
- p.Ile389Thr Single submitter ⚠
- p.Leu302Ile Single submitter ⚠
- p.Leu324Phe Single submitter ⚠
- p.Lys319Glu Single submitter ⚠
- p.Lys322Arg Single submitter ⚠
- p.Lys459Glu Single submitter ⚠
- p.Lys55Asn Single submitter ⚠
- p.Phe449Leu Single submitter ⚠
- p.Pro238Thr Single submitter ⚠
- p.Pro25Arg Single submitter ⚠
- p.Pro30Gln Single submitter ⚠
- p.Pro320Ser Single submitter ⚠
- p.Pro76Leu Single submitter ⚠
- p.Ser153Ala Single submitter ⚠
- p.Ser153Pro Single submitter ⚠
- p.Ser173Ile Single submitter ⚠
- p.Ser290Thr Single submitter ⚠
- p.Ser332Cys Single submitter ⚠
- p.Ser346Cys Single submitter ⚠
- p.Ser446Asn Single submitter ⚠
- p.Thr107Ile Single submitter ⚠
- p.Thr169Ser Single submitter ⚠
- p.Thr222Ala Single submitter ⚠
- p.Trp168Cys Single submitter ⚠
- p.Tyr239Cys Single submitter ⚠
- p.Tyr398Cys Single submitter ⚠
- p.Val36Ala Single submitter ⚠
- p.Val36Leu Single submitter ⚠
- p.Val429Ile Single submitter ⚠
- p.Ala470Pro No assertion criteria ⚠