BNIP2 — 60 ClinVar variants
All ClinVar germline BNIP2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 45 flagged for review →
2 Likely benign · 58 Uncertain significance
Full BNIP2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 45
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 24
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- BNIP2 p.Ala120Glu Uncertain significance Single submitter
- BNIP2 p.Arg131Leu Uncertain significance Single submitter
- BNIP2 p.Arg238Gln Uncertain significance Single submitter
- BNIP2 p.Asp162Val Uncertain significance Single submitter
- BNIP2 p.Asp23Gly Uncertain significance Single submitter
- BNIP2 p.Cys229Phe Uncertain significance Single submitter
- BNIP2 p.Glu36Asp Uncertain significance Single submitter
- BNIP2 p.Gly113Ser Uncertain significance Single submitter
- BNIP2 p.Gly213Asp Uncertain significance Single submitter
- BNIP2 p.Ile147Thr Uncertain significance Single submitter
- BNIP2 p.Ile264Thr Uncertain significance Single submitter
- BNIP2 p.Ile29Thr Uncertain significance Single submitter
- BNIP2 p.Leu53Val Uncertain significance Single submitter
- BNIP2 p.Lys151Ile Uncertain significance Single submitter
- BNIP2 p.Lys192Asn Uncertain significance Single submitter
- BNIP2 p.Lys228Thr Uncertain significance Single submitter
- BNIP2 p.Met132Val Uncertain significance Single submitter
- BNIP2 p.Met207Thr Uncertain significance Single submitter
- BNIP2 p.Pro35Gln Uncertain significance Single submitter
- BNIP2 p.Ser24Thr Uncertain significance Single submitter
- BNIP2 p.Tyr150Cys Uncertain significance Single submitter
- BNIP2 p.Tyr210Cys Uncertain significance Single submitter
- BNIP2 p.Val275Glu Uncertain significance Single submitter
- BNIP2 p.Val275Met Uncertain significance Single submitter
Predictors split 21
The independent predictors disagree with each other — read with care.
- BNIP2 p.Arg131His Uncertain significance Single submitter
- BNIP2 p.Arg134Thr Uncertain significance Single submitter
- BNIP2 p.Asp126His Uncertain significance Single submitter
- BNIP2 p.Asp66Val Uncertain significance Single submitter
- BNIP2 p.Asp75Gly Uncertain significance Single submitter
- BNIP2 p.Asp81Tyr Uncertain significance Single submitter
- BNIP2 p.Glu125Gly Uncertain significance Single submitter
- BNIP2 p.Glu288Gly Uncertain significance Single submitter
- BNIP2 p.Gly224Val Uncertain significance Single submitter
- BNIP2 p.Ile147Val Uncertain significance Single submitter
- BNIP2 p.Ile233Leu Uncertain significance Single submitter
- BNIP2 p.Leu257Val Uncertain significance Single submitter
- BNIP2 p.Leu74Val Uncertain significance Single submitter
- BNIP2 p.Lys51Asn Uncertain significance Single submitter
- BNIP2 p.Met287Val Uncertain significance Single submitter
- BNIP2 p.Pro64Leu Uncertain significance Single submitter
- BNIP2 p.Ser266Leu Uncertain significance Single submitter
- BNIP2 p.Ser68Cys Uncertain significance Single submitter
- BNIP2 p.Thr260Ala Uncertain significance Single submitter
- BNIP2 p.Tyr160Phe Uncertain significance Single submitter
- BNIP2 p.Val290Ile Uncertain significance Single submitter
All BNIP2 variants
Likely benign 2
- c.-138G>A Single submitter
- p.Ile32Val Single submitter
Uncertain significance 58
- c.-101C>G Single submitter
- c.-129G>A Single submitter
- c.-150C>G Single submitter
- c.-159G>A Single submitter
- c.-159G>C Single submitter
- c.-164G>A Single submitter
- c.-173C>T Single submitter
- c.-234G>A Single submitter
- c.-27G>A Single submitter
- c.-2G>C Single submitter
- c.-35A>T Single submitter
- c.-50G>C Single submitter
- c.-78G>A Single submitter
- p.Ala120Glu Single submitter ⚠
- p.Arg131His Single submitter ⚠
- p.Arg131Leu Single submitter ⚠
- p.Arg134Thr Single submitter ⚠
- p.Arg238Gln Single submitter ⚠
- p.Asp126His Single submitter ⚠
- p.Asp162Val Single submitter ⚠
- p.Asp23Gly Single submitter ⚠
- p.Asp66Val Single submitter ⚠
- p.Asp75Gly Single submitter ⚠
- p.Asp81Tyr Single submitter ⚠
- p.Cys229Phe Single submitter ⚠
- p.Glu125Gly Single submitter ⚠
- p.Glu288Gly Single submitter ⚠
- p.Glu36Asp Single submitter ⚠
- p.Gly113Ser Single submitter ⚠
- p.Gly213Asp Single submitter ⚠
- p.Gly224Val Single submitter ⚠
- p.Ile147Thr Single submitter ⚠
- p.Ile147Val Single submitter ⚠
- p.Ile233Leu Single submitter ⚠
- p.Ile264Thr Single submitter ⚠
- p.Ile29Thr Single submitter ⚠
- p.Leu257Val Single submitter ⚠
- p.Leu53Val Single submitter ⚠
- p.Leu74Val Single submitter ⚠
- p.Lys151Ile Single submitter ⚠
- p.Lys192Asn Single submitter ⚠
- p.Lys228Thr Single submitter ⚠
- p.Lys51Asn Single submitter ⚠
- p.Met132Val Single submitter ⚠
- p.Met207Thr Single submitter ⚠
- p.Met287Val Single submitter ⚠
- p.Pro35Gln Single submitter ⚠
- p.Pro64Leu Single submitter ⚠
- p.Ser24Thr Single submitter ⚠
- p.Ser266Leu Single submitter ⚠
- p.Ser68Cys Single submitter ⚠
- p.Thr260Ala Single submitter ⚠
- p.Tyr150Cys Single submitter ⚠
- p.Tyr160Phe Single submitter ⚠
- p.Tyr210Cys Single submitter ⚠
- p.Val275Glu Single submitter ⚠
- p.Val275Met Single submitter ⚠
- p.Val290Ile Single submitter ⚠