BNIP3 — 23 ClinVar variants
All ClinVar germline BNIP3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 16 flagged for review →
23 Uncertain significance
Full BNIP3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 16
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 13
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- BNIP3 p.Ala79Thr Uncertain significance Single submitter
- BNIP3 p.Asn77Asp Uncertain significance Single submitter
- BNIP3 p.Gly8Arg Uncertain significance Single submitter
- BNIP3 p.Gly8Val Uncertain significance Single submitter
- BNIP3 p.His85Arg Uncertain significance Single submitter
- BNIP3 p.Ile100Thr Uncertain significance Single submitter
- BNIP3 p.Ile127Thr Uncertain significance Single submitter
- BNIP3 p.Ile177Val Uncertain significance Single submitter
- BNIP3 p.Leu175Pro Uncertain significance Single submitter
- BNIP3 p.Met43Val Uncertain significance Single submitter
- BNIP3 p.Thr84Ile Uncertain significance Single submitter
- BNIP3 p.Val150Ile Uncertain significance Single submitter
- BNIP3 p.Val32Ala Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All BNIP3 variants
Uncertain significance 23
- p.Ala79Thr Single submitter ⚠
- p.Arg56Trp Single submitter
- p.Arg69Cys Single submitter
- p.Arg69His Single submitter
- p.Asn77Asp Single submitter ⚠
- p.Gly55Arg Single submitter
- p.Gly8Arg Single submitter ⚠
- p.Gly8Val Single submitter ⚠
- p.His85Arg Single submitter ⚠
- p.Ile100Thr Single submitter ⚠
- p.Ile127Thr Single submitter ⚠
- p.Ile177Val Single submitter ⚠
- p.Leu175Pro Single submitter ⚠
- p.Lys130Asn Single submitter
- p.Lys152Gln Single submitter ⚠
- p.Lys153Asn Single submitter ⚠
- p.Lys163Glu Single submitter
- p.Met43Val Single submitter ⚠
- p.Ser57Gly Single submitter ⚠
- p.Ser70Leu Single submitter
- p.Thr84Ile Single submitter ⚠
- p.Val150Ile Single submitter ⚠
- p.Val32Ala Single submitter ⚠