BNIP5 — 9 ClinVar variants
All ClinVar germline BNIP5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 4 flagged for review →
5 Likely benign · 4 Uncertain significance
Full BNIP5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 4
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 3
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 1
The independent predictors disagree with each other — read with care.
-
BNIP5 p.Arg483Trp
Uncertain significance
No assertion criteria
prostate cancer
All BNIP5 variants
Likely benign 5
- p.Arg192His Single submitter
- p.Lys239Arg Single submitter
- p.Lys647Glu Single submitter
- p.Pro133Leu Single submitter
- p.Ser65Pro Single submitter
Uncertain significance 4
- p.Ala503Thr Single submitter ⚠
- p.Arg156Cys Single submitter ⚠
- p.Asp33Gly Single submitter ⚠
- p.Arg483Trp No assertion criteria prostate cancer ⚠