BNIPL — 46 ClinVar variants
All ClinVar germline BNIPL variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 44 flagged for review →
2 Likely benign · 44 Uncertain significance
Full BNIPL gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 44
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 17
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- BNIPL p.Arg149Gly Uncertain significance Single submitter
- BNIPL p.Arg186Gln Uncertain significance Single submitter
- BNIPL p.Arg240Ser Uncertain significance Single submitter
- BNIPL p.Arg29Gly Uncertain significance Single submitter
- BNIPL p.Glu23Asp Uncertain significance Single submitter
- BNIPL p.Gly117Val Uncertain significance Single submitter
- BNIPL p.Gly31Glu Uncertain significance Single submitter
- BNIPL p.Ile123Arg Uncertain significance Single submitter
- BNIPL p.Ile123Thr Uncertain significance Single submitter
- BNIPL p.Ile312Leu Uncertain significance Single submitter
- BNIPL p.Leu289Pro Uncertain significance Single submitter
- BNIPL p.Leu33Val Uncertain significance Single submitter
- BNIPL p.Leu347Pro Uncertain significance Single submitter
- BNIPL p.Met167Ile Uncertain significance Single submitter
- BNIPL p.Ser132Leu Uncertain significance Single submitter
- BNIPL p.Thr298Pro Uncertain significance Single submitter
- BNIPL p.Thr54Ser Uncertain significance Single submitter
Predictors split 27
The independent predictors disagree with each other — read with care.
- BNIPL p.Arg182Gln Uncertain significance Single submitter
- BNIPL p.Arg189Cys Uncertain significance Single submitter
- BNIPL p.Arg275His Uncertain significance Single submitter
- BNIPL p.Arg279Cys Uncertain significance Single submitter
- BNIPL p.Arg284Trp Uncertain significance Single submitter
- BNIPL p.Arg290Gln Uncertain significance Single submitter
- BNIPL p.Arg309Gln Uncertain significance Single submitter
- BNIPL p.Arg81Cys Uncertain significance Single submitter
- BNIPL p.Arg84Cys Uncertain significance Single submitter
- BNIPL p.Arg84His Uncertain significance Single submitter
- BNIPL p.Arg86His Uncertain significance Single submitter
- BNIPL p.Arg93Trp Uncertain significance Single submitter
- BNIPL p.Asp124Gly Uncertain significance Single submitter
- BNIPL p.Cys277Ser Uncertain significance Single submitter
- BNIPL p.Glu125Lys Uncertain significance Single submitter
- BNIPL p.Glu342Lys Uncertain significance Single submitter
- BNIPL p.Gly175Glu Uncertain significance Single submitter
- BNIPL p.Gly211Asp Uncertain significance Single submitter
- BNIPL p.Gly244Arg Uncertain significance Single submitter
- BNIPL p.His176Tyr Uncertain significance Single submitter
- BNIPL p.His177Tyr Uncertain significance Single submitter
- BNIPL p.His204Leu Uncertain significance Single submitter
- BNIPL p.Leu121Met Uncertain significance Single submitter
- BNIPL p.Leu351Phe Uncertain significance Single submitter
- BNIPL p.Ser137Asn Uncertain significance Single submitter
- BNIPL p.Ser354Leu Uncertain significance Single submitter
- BNIPL p.Val180Glu Uncertain significance Single submitter
All BNIPL variants
Likely benign 2
- p.Ala111Thr Single submitter
- p.Arg164Gln Single submitter
Uncertain significance 44
- p.Arg149Gly Single submitter ⚠
- p.Arg182Gln Single submitter ⚠
- p.Arg186Gln Single submitter ⚠
- p.Arg189Cys Single submitter ⚠
- p.Arg240Ser Single submitter ⚠
- p.Arg275His Single submitter ⚠
- p.Arg279Cys Single submitter ⚠
- p.Arg284Trp Single submitter ⚠
- p.Arg290Gln Single submitter ⚠
- p.Arg29Gly Single submitter ⚠
- p.Arg309Gln Single submitter ⚠
- p.Arg81Cys Single submitter ⚠
- p.Arg84Cys Single submitter ⚠
- p.Arg84His Single submitter ⚠
- p.Arg86His Single submitter ⚠
- p.Arg93Trp Single submitter ⚠
- p.Asp124Gly Single submitter ⚠
- p.Cys277Ser Single submitter ⚠
- p.Glu125Lys Single submitter ⚠
- p.Glu23Asp Single submitter ⚠
- p.Glu342Lys Single submitter ⚠
- p.Gly117Val Single submitter ⚠
- p.Gly175Glu Single submitter ⚠
- p.Gly211Asp Single submitter ⚠
- p.Gly244Arg Single submitter ⚠
- p.Gly31Glu Single submitter ⚠
- p.His176Tyr Single submitter ⚠
- p.His177Tyr Single submitter ⚠
- p.His204Leu Single submitter ⚠
- p.Ile123Arg Single submitter ⚠
- p.Ile123Thr Single submitter ⚠
- p.Ile312Leu Single submitter ⚠
- p.Leu121Met Single submitter ⚠
- p.Leu289Pro Single submitter ⚠
- p.Leu33Val Single submitter ⚠
- p.Leu347Pro Single submitter ⚠
- p.Leu351Phe Single submitter ⚠
- p.Met167Ile Single submitter ⚠
- p.Ser132Leu Single submitter ⚠
- p.Ser137Asn Single submitter ⚠
- p.Ser354Leu Single submitter ⚠
- p.Thr298Pro Single submitter ⚠
- p.Thr54Ser Single submitter ⚠
- p.Val180Glu Single submitter ⚠