BOK — 52 ClinVar variants
All ClinVar germline BOK variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 51 flagged for review →
1 Likely benign · 51 Uncertain significance
Full BOK gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 51
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 26
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- BOK p.Ala148Thr Uncertain significance Single submitter
- BOK p.Ala192Val Uncertain significance Single submitter
- BOK p.Ala41Thr Uncertain significance Single submitter
- BOK p.Ala56Gly Uncertain significance Single submitter
- BOK p.Ala64Ser Uncertain significance Single submitter
- BOK p.Arg186Gly Uncertain significance Single submitter
- BOK p.Arg186His Uncertain significance Single submitter
- BOK p.Arg42Gly Uncertain significance Single submitter
- BOK p.Glu54Asp Uncertain significance Single submitter
- BOK p.Gly170Arg Uncertain significance Single submitter
- BOK p.Gly198Ser Uncertain significance Single submitter
- BOK p.Leu149Pro Uncertain significance Single submitter
- BOK p.Met145Val Uncertain significance Single submitter
- BOK p.Met15Val Uncertain significance Single submitter
- BOK p.Met79Val Uncertain significance Single submitter
- BOK p.Phe156Leu Uncertain significance Single submitter
- BOK p.Pro183Thr Uncertain significance Single submitter
- BOK p.Pro82Leu Uncertain significance Single submitter
- BOK p.Ser49Pro Uncertain significance Single submitter
- BOK p.Tyr127Cys Uncertain significance Single submitter
- BOK p.Tyr85Cys Uncertain significance Single submitter
- BOK p.Val129Met Uncertain significance Single submitter
- BOK p.Val179Ala Uncertain significance Single submitter
- BOK p.Val179Asp Uncertain significance Single submitter
- BOK p.Val191Leu Uncertain significance Single submitter
- BOK p.Val69Gly Uncertain significance Single submitter
Predictors split 25
The independent predictors disagree with each other — read with care.
- BOK p.Ala11Val Uncertain significance Single submitter
- BOK p.Ala12Gly Uncertain significance Single submitter
- BOK p.Ala141Thr Uncertain significance Single submitter
- BOK p.Ala57Thr Uncertain significance Single submitter
- BOK p.Arg158Cys Uncertain significance Single submitter
- BOK p.Arg158His Uncertain significance Single submitter
- BOK p.Arg62Leu Uncertain significance Single submitter
- BOK p.Arg72Cys Uncertain significance Single submitter
- BOK p.Arg90His Uncertain significance Single submitter
- BOK p.Gln142Glu Uncertain significance Single submitter
- BOK p.Gln91Glu Uncertain significance Single submitter
- BOK p.Glu155Val Uncertain significance Single submitter
- BOK p.Ile94Thr Uncertain significance Single submitter
- BOK p.Pro53Leu Uncertain significance Single submitter
- BOK p.Pro58Arg Uncertain significance Single submitter
- BOK p.Ser125Thr Uncertain significance Single submitter
- BOK p.Ser98Tyr Uncertain significance Single submitter
- BOK p.Trp50Cys Uncertain significance Single submitter
- BOK p.Tyr38Asn Uncertain significance Single submitter
- BOK p.Val124Ala Uncertain significance Single submitter
- BOK p.Val135Leu Uncertain significance Single submitter
- BOK p.Val135Met Uncertain significance Single submitter
- BOK p.Val157Met Uncertain significance Single submitter
- BOK p.Val191Met Uncertain significance Single submitter
- BOK p.Val59Gly Uncertain significance Single submitter
All BOK variants
Likely benign 1
- p.Thr103= Single submitter
Uncertain significance 51
- p.Ala11Val Single submitter ⚠
- p.Ala12Gly Single submitter ⚠
- p.Ala141Thr Single submitter ⚠
- p.Ala148Thr Single submitter ⚠
- p.Ala192Val Single submitter ⚠
- p.Ala41Thr Single submitter ⚠
- p.Ala56Gly Single submitter ⚠
- p.Ala57Thr Single submitter ⚠
- p.Ala64Ser Single submitter ⚠
- p.Arg158Cys Single submitter ⚠
- p.Arg158His Single submitter ⚠
- p.Arg186Gly Single submitter ⚠
- p.Arg186His Single submitter ⚠
- p.Arg42Gly Single submitter ⚠
- p.Arg62Leu Single submitter ⚠
- p.Arg72Cys Single submitter ⚠
- p.Arg90His Single submitter ⚠
- p.Gln142Glu Single submitter ⚠
- p.Gln91Glu Single submitter ⚠
- p.Glu155Val Single submitter ⚠
- p.Glu54Asp Single submitter ⚠
- p.Gly170Arg Single submitter ⚠
- p.Gly198Ser Single submitter ⚠
- p.Ile94Thr Single submitter ⚠
- p.Leu149Pro Single submitter ⚠
- p.Met145Val Single submitter ⚠
- p.Met15Val Single submitter ⚠
- p.Met79Val Single submitter ⚠
- p.Phe156Leu Single submitter ⚠
- p.Pro183Thr Single submitter ⚠
- p.Pro53Leu Single submitter ⚠
- p.Pro58Arg Single submitter ⚠
- p.Pro82Leu Single submitter ⚠
- p.Ser125Thr Single submitter ⚠
- p.Ser49Pro Single submitter ⚠
- p.Ser98Tyr Single submitter ⚠
- p.Trp50Cys Single submitter ⚠
- p.Tyr127Cys Single submitter ⚠
- p.Tyr38Asn Single submitter ⚠
- p.Tyr85Cys Single submitter ⚠
- p.Val124Ala Single submitter ⚠
- p.Val129Met Single submitter ⚠
- p.Val135Leu Single submitter ⚠
- p.Val135Met Single submitter ⚠
- p.Val157Met Single submitter ⚠
- p.Val179Ala Single submitter ⚠
- p.Val179Asp Single submitter ⚠
- p.Val191Leu Single submitter ⚠
- p.Val191Met Single submitter ⚠
- p.Val59Gly Single submitter ⚠
- p.Val69Gly Single submitter ⚠