BPIFB2 — 74 ClinVar variants
All ClinVar germline BPIFB2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 68 flagged for review →
9 Likely benign · 65 Uncertain significance
Full BPIFB2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 68
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 35
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- BPIFB2 p.Ala104Ser Uncertain significance Single submitter
- BPIFB2 p.Ala104Thr Uncertain significance Single submitter
- BPIFB2 p.Ala144Thr Uncertain significance Single submitter
- BPIFB2 p.Ala267Val Uncertain significance Single submitter
- BPIFB2 p.Ala274Thr Uncertain significance Single submitter
- BPIFB2 p.Ala63Glu Uncertain significance Single submitter
- BPIFB2 p.Arg121His Uncertain significance Single submitter
- BPIFB2 p.Arg319Leu Uncertain significance Single submitter
- BPIFB2 p.Arg47Gln Uncertain significance Single submitter
- BPIFB2 p.Asp288Asn Uncertain significance Single submitter
- BPIFB2 p.Asp398His Uncertain significance Single submitter
- BPIFB2 p.Gly189Ser Uncertain significance Single submitter
- BPIFB2 p.Gly252Arg Uncertain significance Single submitter
- BPIFB2 p.Gly252Val Uncertain significance Single submitter
- BPIFB2 p.Gly430Ala Uncertain significance Single submitter
- BPIFB2 p.Gly88Arg Uncertain significance Single submitter
- BPIFB2 p.Leu271Pro Uncertain significance Single submitter
- BPIFB2 p.Lys273Arg Uncertain significance Single submitter
- BPIFB2 p.Met312Val Uncertain significance Single submitter
- BPIFB2 p.Met327Lys Uncertain significance Single submitter
- BPIFB2 p.Phe396Ile Uncertain significance Single submitter
- BPIFB2 p.Pro113Ser Uncertain significance Single submitter
- BPIFB2 p.Ser133Asn Uncertain significance Single submitter
- BPIFB2 p.Ser176Thr Uncertain significance Single submitter
- BPIFB2 p.Ser215Gly Uncertain significance Single submitter
- BPIFB2 p.Ser260Phe Uncertain significance Single submitter
- BPIFB2 p.Ser287Leu Uncertain significance Single submitter
- BPIFB2 p.Thr237Met Uncertain significance Single submitter
- BPIFB2 p.Thr323Ala Uncertain significance Single submitter
- BPIFB2 p.Thr379Met Uncertain significance Single submitter
- BPIFB2 p.Thr388Ala Uncertain significance Single submitter
- BPIFB2 p.Trp59Cys Uncertain significance Single submitter
- BPIFB2 p.Val225Ala Uncertain significance Single submitter
- BPIFB2 p.Val225Ile Uncertain significance Single submitter
- BPIFB2 p.Val448Leu Uncertain significance Single submitter
Predictors split 33
The independent predictors disagree with each other — read with care.
- BPIFB2 p.Ala420Val Uncertain significance Single submitter
- BPIFB2 p.Ala48Ser Uncertain significance Single submitter
- BPIFB2 p.Arg121Cys Uncertain significance Single submitter
- BPIFB2 p.Arg28Gln Uncertain significance Single submitter
- BPIFB2 p.Arg299Trp Likely benign Single submitter
- BPIFB2 p.Arg319Trp Uncertain significance Single submitter
- BPIFB2 p.Arg403Cys Uncertain significance Single submitter
- BPIFB2 p.Arg47Trp Uncertain significance Single submitter
- BPIFB2 p.Arg78Cys Uncertain significance Single submitter
- BPIFB2 p.Asn419Lys Uncertain significance Single submitter
- BPIFB2 p.Asn433Ser Uncertain significance Single submitter
- BPIFB2 p.Asp280Tyr Uncertain significance Single submitter
- BPIFB2 p.Asp416Asn Uncertain significance Single submitter
- BPIFB2 p.Asp416Val Uncertain significance Single submitter
- BPIFB2 p.Gly249Cys Uncertain significance Single submitter
- BPIFB2 p.Gly8Asp Uncertain significance Single submitter
- BPIFB2 p.His329Tyr Uncertain significance Single submitter
- BPIFB2 p.His80Tyr Uncertain significance Single submitter
- BPIFB2 p.Ile397Phe Uncertain significance Single submitter
- BPIFB2 p.Leu291Arg Uncertain significance Single submitter
- BPIFB2 p.Leu292Pro Uncertain significance Single submitter
- BPIFB2 p.Phe308Leu Uncertain significance Single submitter
- BPIFB2 p.Pro199Thr Uncertain significance Single submitter
- BPIFB2 p.Ser138Phe Likely benign Single submitter
- BPIFB2 p.Ser219Phe Uncertain significance Single submitter
- BPIFB2 p.Ser21Phe Uncertain significance Single submitter
- BPIFB2 p.Ser350Leu Uncertain significance Single submitter
- BPIFB2 p.Thr334Ser Uncertain significance Single submitter
- BPIFB2 p.Tyr436Cys Uncertain significance Single submitter
- BPIFB2 p.Val17Glu Likely benign Single submitter
- BPIFB2 p.Val360Gly Uncertain significance Single submitter
- BPIFB2 p.Val437Phe Uncertain significance Single submitter
- BPIFB2 p.Val448Met Uncertain significance Single submitter
All BPIFB2 variants
Likely benign 9
- p.Ala438Thr Single submitter
- p.Arg299Trp Single submitter ⚠
- p.Glu251Lys Single submitter
- p.Gly19Ser Single submitter
- p.Pro302= Single submitter
- p.Ser138Phe Single submitter ⚠
- p.Ser141Leu Single submitter
- p.Ser170Arg Single submitter
- p.Val17Glu Single submitter ⚠
Uncertain significance 65
- p.Ala104Ser Single submitter ⚠
- p.Ala104Thr Single submitter ⚠
- p.Ala144Thr Single submitter ⚠
- p.Ala267Val Single submitter ⚠
- p.Ala274Thr Single submitter ⚠
- p.Ala420Val Single submitter ⚠
- p.Ala48Ser Single submitter ⚠
- p.Ala63Glu Single submitter ⚠
- p.Arg121Cys Single submitter ⚠
- p.Arg121His Single submitter ⚠
- p.Arg28Gln Single submitter ⚠
- p.Arg319Leu Single submitter ⚠
- p.Arg319Trp Single submitter ⚠
- p.Arg403Cys Single submitter ⚠
- p.Arg47Gln Single submitter ⚠
- p.Arg47Trp Single submitter ⚠
- p.Arg78Cys Single submitter ⚠
- p.Asn419Lys Single submitter ⚠
- p.Asn433Ser Single submitter ⚠
- p.Asp280Tyr Single submitter ⚠
- p.Asp288Asn Single submitter ⚠
- p.Asp398His Single submitter ⚠
- p.Asp416Asn Single submitter ⚠
- p.Asp416Val Single submitter ⚠
- p.Gly189Ser Single submitter ⚠
- p.Gly249Cys Single submitter ⚠
- p.Gly252Arg Single submitter ⚠
- p.Gly252Val Single submitter ⚠
- p.Gly430Ala Single submitter ⚠
- p.Gly88Arg Single submitter ⚠
- p.Gly8Asp Single submitter ⚠
- p.His329Tyr Single submitter ⚠
- p.His80Tyr Single submitter ⚠
- p.Ile397Phe Single submitter ⚠
- p.Leu271Pro Single submitter ⚠
- p.Leu291Arg Single submitter ⚠
- p.Leu292Pro Single submitter ⚠
- p.Lys273Arg Single submitter ⚠
- p.Met312Val Single submitter ⚠
- p.Met327Lys Single submitter ⚠
- p.Phe308Leu Single submitter ⚠
- p.Phe396Ile Single submitter ⚠
- p.Pro113Ser Single submitter ⚠
- p.Pro199Thr Single submitter ⚠
- p.Ser133Asn Single submitter ⚠
- p.Ser176Thr Single submitter ⚠
- p.Ser215Gly Single submitter ⚠
- p.Ser219Phe Single submitter ⚠
- p.Ser21Phe Single submitter ⚠
- p.Ser260Phe Single submitter ⚠
- p.Ser287Leu Single submitter ⚠
- p.Ser350Leu Single submitter ⚠
- p.Thr237Met Single submitter ⚠
- p.Thr323Ala Single submitter ⚠
- p.Thr334Ser Single submitter ⚠
- p.Thr379Met Single submitter ⚠
- p.Thr388Ala Single submitter ⚠
- p.Trp59Cys Single submitter ⚠
- p.Tyr436Cys Single submitter ⚠
- p.Val225Ala Single submitter ⚠
- p.Val225Ile Single submitter ⚠
- p.Val360Gly Single submitter ⚠
- p.Val437Phe Single submitter ⚠
- p.Val448Leu Single submitter ⚠
- p.Val448Met Single submitter ⚠