BRAP — 68 ClinVar variants
All ClinVar germline BRAP variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 61 flagged for review →
6 Benign · 1 Likely benign · 61 Uncertain significance
Full BRAP gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 61
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 44
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- BRAP p.Ala100Val Uncertain significance Single submitter
- BRAP p.Ala379Val Uncertain significance Single submitter
- BRAP p.Ala403Ser Uncertain significance Single submitter
- BRAP p.Ala481Gly Uncertain significance Single submitter
- BRAP p.Ala565Thr Uncertain significance Single submitter
- BRAP p.Arg158Gln Uncertain significance Single submitter
- BRAP p.Arg209His Uncertain significance Single submitter
- BRAP p.Arg241Lys Uncertain significance Single submitter
- BRAP p.Arg420Gln Uncertain significance Single submitter
- BRAP p.Arg498Gln Uncertain significance Single submitter
- BRAP p.Arg554Gln Uncertain significance Single submitter
- BRAP p.Arg66His Uncertain significance Single submitter
- BRAP p.Arg91Lys Uncertain significance Single submitter
- BRAP p.Asn276Ser Uncertain significance Single submitter
- BRAP p.Asn284Thr Uncertain significance Single submitter
- BRAP p.Asn439Lys Uncertain significance Single submitter
- BRAP p.Asp453Tyr Uncertain significance Single submitter
- BRAP p.Asp535Glu Uncertain significance Single submitter
- BRAP p.Asp71His Uncertain significance Single submitter
- BRAP p.Cys110Tyr Uncertain significance Single submitter
- BRAP p.Cys267Gly Uncertain significance Single submitter
- BRAP p.Gln125Leu Uncertain significance Single submitter
- BRAP p.Glu109Asp Uncertain significance Single submitter
- BRAP p.Glu49Lys Uncertain significance Single submitter
- BRAP p.Glu512Lys Uncertain significance Single submitter
- BRAP p.Gly393Glu Uncertain significance Single submitter
- BRAP p.Gly576Arg Uncertain significance Single submitter
- BRAP p.Gly65Cys Uncertain significance Single submitter
- BRAP p.His106Asn Uncertain significance Single submitter
- BRAP p.Ile165Val Uncertain significance Single submitter
- BRAP p.Ile206Val Uncertain significance Single submitter
- BRAP p.Leu245Phe Uncertain significance Single submitter
- BRAP p.Lys482Arg Uncertain significance Single submitter
- BRAP p.Lys589Arg Uncertain significance Single submitter
- BRAP p.Met441Leu Uncertain significance Single submitter
- BRAP p.Met441Val Uncertain significance Single submitter
- BRAP p.Met566Thr Uncertain significance Single submitter
- BRAP p.Met77Val Uncertain significance Single submitter
- BRAP p.Pro254Ala Uncertain significance Single submitter
- BRAP p.Thr39Arg Uncertain significance Single submitter
- BRAP p.Thr39Met Uncertain significance Single submitter
- BRAP p.Tyr539Phe Uncertain significance Single submitter
- BRAP p.Val469Met Uncertain significance Single submitter
- BRAP p.Val514Met Uncertain significance Single submitter
Predictors split 17
The independent predictors disagree with each other — read with care.
- BRAP p.Arg534His Uncertain significance Single submitter
- BRAP p.Arg587His Uncertain significance Single submitter
- BRAP p.Glu189Gly Uncertain significance Single submitter
- BRAP p.Glu310Lys Uncertain significance Single submitter
- BRAP p.Glu486Lys Uncertain significance Single submitter
- BRAP p.Glu55Gln Uncertain significance Single submitter
- BRAP p.Gly393Arg Uncertain significance Single submitter
- BRAP p.Gly577Asp Uncertain significance Single submitter
- BRAP p.Gly586Val Uncertain significance Single submitter
- BRAP p.Ile526Val Uncertain significance Single submitter
- BRAP p.Lys316Thr Uncertain significance Single submitter
- BRAP p.Lys488Arg Uncertain significance Single submitter
- BRAP p.Met441Ile Uncertain significance Single submitter
- BRAP p.Ser468Phe Uncertain significance Single submitter
- BRAP p.Ser571Arg Uncertain significance Single submitter
- BRAP p.Val312Ala Uncertain significance Single submitter
- BRAP p.Val7Leu Uncertain significance Single submitter
All BRAP variants
Benign 6
Likely benign 1
- p.Lys458Arg Single submitter
Uncertain significance 61
- p.Ala100Val Single submitter ⚠
- p.Ala379Val Single submitter ⚠
- p.Ala403Ser Single submitter ⚠
- p.Ala481Gly Single submitter ⚠
- p.Ala565Thr Single submitter ⚠
- p.Arg158Gln Single submitter ⚠
- p.Arg209His Single submitter ⚠
- p.Arg241Lys Single submitter ⚠
- p.Arg420Gln Single submitter ⚠
- p.Arg498Gln Single submitter ⚠
- p.Arg534His Single submitter ⚠
- p.Arg554Gln Single submitter ⚠
- p.Arg587His Single submitter ⚠
- p.Arg66His Single submitter ⚠
- p.Arg91Lys Single submitter ⚠
- p.Asn276Ser Single submitter ⚠
- p.Asn284Thr Single submitter ⚠
- p.Asn439Lys Single submitter ⚠
- p.Asp453Tyr Single submitter ⚠
- p.Asp535Glu Single submitter ⚠
- p.Asp71His Single submitter ⚠
- p.Cys110Tyr Single submitter ⚠
- p.Cys267Gly Single submitter ⚠
- p.Gln125Leu Single submitter ⚠
- p.Glu109Asp Single submitter ⚠
- p.Glu189Gly Single submitter ⚠
- p.Glu310Lys Single submitter ⚠
- p.Glu486Lys Single submitter ⚠
- p.Glu49Lys Single submitter ⚠
- p.Glu512Lys Single submitter ⚠
- p.Glu55Gln Single submitter ⚠
- p.Gly393Arg Single submitter ⚠
- p.Gly393Glu Single submitter ⚠
- p.Gly576Arg Single submitter ⚠
- p.Gly577Asp Single submitter ⚠
- p.Gly586Val Single submitter ⚠
- p.Gly65Cys Single submitter ⚠
- p.His106Asn Single submitter ⚠
- p.Ile165Val Single submitter ⚠
- p.Ile206Val Single submitter ⚠
- p.Ile526Val Single submitter ⚠
- p.Leu245Phe Single submitter ⚠
- p.Lys316Thr Single submitter ⚠
- p.Lys482Arg Single submitter ⚠
- p.Lys488Arg Single submitter ⚠
- p.Lys589Arg Single submitter ⚠
- p.Met441Ile Single submitter ⚠
- p.Met441Leu Single submitter ⚠
- p.Met441Val Single submitter ⚠
- p.Met566Thr Single submitter ⚠
- p.Met77Val Single submitter ⚠
- p.Pro254Ala Single submitter ⚠
- p.Ser468Phe Single submitter ⚠
- p.Ser571Arg Single submitter ⚠
- p.Thr39Arg Single submitter ⚠
- p.Thr39Met Single submitter ⚠
- p.Tyr539Phe Single submitter ⚠
- p.Val312Ala Single submitter ⚠
- p.Val469Met Single submitter ⚠
- p.Val514Met Single submitter ⚠
- p.Val7Leu Single submitter ⚠