BRCC3 — 18 ClinVar variants
All ClinVar germline BRCC3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 6 flagged for review →
1 Benign · 11 Likely benign · 6 Uncertain significance
Full BRCC3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 6
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 5
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 1
The independent predictors disagree with each other — read with care.
All BRCC3 variants
Benign 1
- c.681-9A>G Single submitter
Likely benign 11
- c.403+205A>G Single submitter hereditary neoplastic syndrome
- p.7QAV[1] Single submitter
- p.Ser227= Single submitter
- p.Thr138= Single submitter
- c.123+84T>C No assertion criteria hereditary neoplastic syndrome
- c.196-1496T>C No assertion criteria hereditary neoplastic syndrome
- c.403+241A>G No assertion criteria hereditary neoplastic syndrome
- c.403+3165C>A No assertion criteria hereditary neoplastic syndrome
- c.403+3171G>A No assertion criteria hereditary neoplastic syndrome
- c.493-404C>T No assertion criteria hereditary neoplastic syndrome
- c.548+8153A>G No assertion criteria hereditary neoplastic syndrome
Uncertain significance 6
- p.Val202Ala Multiple submitters ⚠
- p.Gln147Arg Single submitter ⚠
- p.Ile187Met Single submitter ⚠
- p.Leu273Phe Single submitter ⚠
- p.Met59Val Single submitter ⚠
- p.Thr46Lys Single submitter ⚠