BRD1 — 129 ClinVar variants
All ClinVar germline BRD1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 98 flagged for review →
11 Benign · 22 Likely benign · 96 Uncertain significance
Full BRD1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 98
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 57
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- BRD1 p.Ala442Val Uncertain significance Single submitter
- BRD1 p.Ala449Thr Uncertain significance Single submitter
- BRD1 p.Ala461Val Uncertain significance Single submitter
- BRD1 p.Ala559Thr Uncertain significance Single submitter
- BRD1 p.Ala778Val Uncertain significance Single submitter
- BRD1 p.Ala783Val Uncertain significance Single submitter
- BRD1 p.Ala961Val Uncertain significance Single submitter
- BRD1 p.Ala975Pro Uncertain significance Single submitter
- BRD1 p.Arg1020His Uncertain significance Single submitter
- BRD1 p.Arg1085Cys Uncertain significance Single submitter
- BRD1 p.Arg1169Cys Uncertain significance Single submitter
- BRD1 p.Arg123His Uncertain significance Single submitter
- BRD1 p.Arg563Gln Uncertain significance Single submitter
- BRD1 p.Arg686Gln Uncertain significance Single submitter
- BRD1 p.Arg692Gln Uncertain significance Single submitter
- BRD1 p.Arg933Gly Uncertain significance Single submitter
- BRD1 p.Arg978Leu Uncertain significance Single submitter
- BRD1 p.Arg979Gln Uncertain significance Single submitter
- BRD1 p.Asn462Ser Uncertain significance Single submitter
- BRD1 p.Asp531Asn Uncertain significance Single submitter
- BRD1 p.Asp632His Uncertain significance Single submitter
- BRD1 p.Asp938Gly Uncertain significance Single submitter
- BRD1 p.Asp996Tyr Uncertain significance Single submitter
- BRD1 p.Cys441Arg Uncertain significance Single submitter
- BRD1 p.Glu514Ala Uncertain significance Single submitter
- BRD1 p.Glu556Lys Uncertain significance Single submitter
- BRD1 p.Glu629Lys Uncertain significance Single submitter
- BRD1 p.Glu944Ala Uncertain significance Single submitter
- BRD1 p.Glu964Gln Uncertain significance Single submitter
- BRD1 p.Gly1043Ala Uncertain significance Single submitter
- BRD1 p.Gly1043Ser Uncertain significance Single submitter
- BRD1 p.Gly620Glu Uncertain significance Single submitter
- BRD1 p.Gly960Asp Uncertain significance Single submitter
- BRD1 p.His625Arg Uncertain significance Single submitter
- BRD1 p.Ile1146Val Uncertain significance Single submitter
- BRD1 p.Ile460Phe Uncertain significance Single submitter
- BRD1 p.Ile466Val Uncertain significance Single submitter
- BRD1 p.Leu994Pro Uncertain significance Single submitter
- BRD1 p.Lys331Gln Uncertain significance Single submitter
- BRD1 p.Pro1072Arg Uncertain significance Single submitter
- BRD1 p.Pro130Leu Uncertain significance Single submitter
- BRD1 p.Pro491His Uncertain significance Single submitter
- BRD1 p.Pro590Ala Uncertain significance Single submitter
- BRD1 p.Pro691Leu Uncertain significance Single submitter
- BRD1 p.Pro993Leu Uncertain significance Single submitter
- BRD1 p.Pro993Thr Uncertain significance Single submitter
- BRD1 p.Ser1021Gly Uncertain significance Single submitter
- BRD1 p.Ser1021Thr Uncertain significance Single submitter
- BRD1 p.Ser1045Gly Uncertain significance Single submitter
- BRD1 p.Thr30Ala Uncertain significance Single submitter
- BRD1 p.Thr565Ser Uncertain significance Single submitter
- BRD1 p.Trp697Cys Uncertain significance Single submitter
- BRD1 p.Tyr139Cys Uncertain significance Single submitter
- BRD1 p.Tyr328Ser Uncertain significance Single submitter
- BRD1 p.Val1093Ile Uncertain significance Single submitter
- BRD1 p.Val85Ala Uncertain significance Single submitter
- BRD1 p.Val97Gly Uncertain significance Single submitter
Predictors split 41
The independent predictors disagree with each other — read with care.
- BRD1 p.Gly776Arg Benign Multiple submitters
- BRD1 p.Ala1039Thr Uncertain significance Single submitter
- BRD1 p.Arg1014Trp Uncertain significance Single submitter
- BRD1 p.Arg192Cys Uncertain significance Single submitter
- BRD1 p.Arg267Trp Uncertain significance Single submitter
- BRD1 p.Arg550His Uncertain significance Single submitter
- BRD1 p.Arg667Gln Uncertain significance Single submitter
- BRD1 p.Arg686Trp Uncertain significance Single submitter
- BRD1 p.Arg929Thr Uncertain significance Single submitter
- BRD1 p.Arg933Gln Uncertain significance Single submitter
- BRD1 p.Arg933Trp Uncertain significance Single submitter
- BRD1 p.Arg949His Uncertain significance Single submitter
- BRD1 p.Arg978Gln Uncertain significance Single submitter
- BRD1 p.Arg980Cys Uncertain significance Single submitter
- BRD1 p.Asn1172Asp Uncertain significance Single submitter
- BRD1 p.Asn305Ser Uncertain significance Single submitter
- BRD1 p.Asn708Asp Uncertain significance Single submitter
- BRD1 p.Asp1101Glu Uncertain significance Single submitter
- BRD1 p.Asp63Asn Uncertain significance Single submitter
- BRD1 p.Gln665His Uncertain significance Single submitter
- BRD1 p.Glu1107Gln Uncertain significance Single submitter
- BRD1 p.Glu41Asp Uncertain significance Single submitter
- BRD1 p.Gly1179Arg Uncertain significance Single submitter
- BRD1 p.Gly735Cys Uncertain significance Single submitter
- BRD1 p.Gly735Ser Uncertain significance Single submitter
- BRD1 p.Ile1105Thr Uncertain significance Single submitter
- BRD1 p.Leu750Phe Uncertain significance Single submitter
- BRD1 p.Met190Leu Uncertain significance Single submitter
- BRD1 p.Met236Val Uncertain significance Single submitter
- BRD1 p.Met607Val Uncertain significance Single submitter
- BRD1 p.Pro111Leu Uncertain significance Single submitter
- BRD1 p.Ser1025Phe Uncertain significance Single submitter
- BRD1 p.Ser1175Asn Uncertain significance Single submitter
- BRD1 p.Ser505Asn Likely benign Single submitter
- BRD1 p.Ser505Cys Uncertain significance Single submitter
- BRD1 p.Ser990Asn Uncertain significance Single submitter
- BRD1 p.Val138Met Uncertain significance Single submitter
- BRD1 p.Val443Ile Likely benign Single submitter
- BRD1 p.Val447Met Uncertain significance Single submitter
- BRD1 p.Val464Met Uncertain significance Single submitter
- BRD1 p.Val647Met Uncertain significance Single submitter
All BRD1 variants
Benign 11
- p.Ala1053= Multiple submitters
- p.Ala730Thr Multiple submitters
- p.Arg1020= Multiple submitters
- p.Gly776Arg Multiple submitters ⚠
- p.Phe193= Multiple submitters
- p.Pro111= Multiple submitters
- p.Ser106Thr Multiple submitters
- p.Ala689Val Single submitter
- p.Asp403Gly Single submitter
- p.Gly771= Single submitter
- p.Val1093= Single submitter
Likely benign 22
- c.1657-4C>T Multiple submitters
- p.Gly620= Multiple submitters
- p.Tyr401= Multiple submitters
- c.3122-4G>A Single submitter
- p.Ala588= Single submitter
- p.Ala783= Single submitter
- p.Arg1176= Single submitter
- p.Asp512= Single submitter
- p.Cys936= Single submitter
- p.Glu414Gly Single submitter
- p.Gly372= Single submitter
- p.Gly969Ser Single submitter
- p.Ile124= Single submitter
- p.Ile673Val Single submitter
- p.Leu1103= Single submitter
- p.Pro706= Single submitter
- p.Pro781Leu Single submitter
- p.Ser1183= Single submitter
- p.Ser505Asn Single submitter ⚠
- p.Thr348= Single submitter
- p.Tyr33= Single submitter
- p.Val443Ile Single submitter ⚠
Uncertain significance 96
- p.Ala1039Thr Single submitter ⚠
- p.Ala442Val Single submitter ⚠
- p.Ala449Thr Single submitter ⚠
- p.Ala461Val Single submitter ⚠
- p.Ala559Thr Single submitter ⚠
- p.Ala778Val Single submitter ⚠
- p.Ala783Val Single submitter ⚠
- p.Ala961Val Single submitter ⚠
- p.Ala975Pro Single submitter ⚠
- p.Arg1014Trp Single submitter ⚠
- p.Arg1020His Single submitter ⚠
- p.Arg1085Cys Single submitter ⚠
- p.Arg1169Cys Single submitter ⚠
- p.Arg123His Single submitter ⚠
- p.Arg192Cys Single submitter ⚠
- p.Arg267Trp Single submitter ⚠
- p.Arg550His Single submitter ⚠
- p.Arg563Gln Single submitter ⚠
- p.Arg667Gln Single submitter ⚠
- p.Arg686Gln Single submitter ⚠
- p.Arg686Trp Single submitter ⚠
- p.Arg692Gln Single submitter ⚠
- p.Arg929Thr Single submitter ⚠
- p.Arg933Gln Single submitter ⚠
- p.Arg933Gly Single submitter ⚠
- p.Arg933Trp Single submitter ⚠
- p.Arg949His Single submitter ⚠
- p.Arg978Gln Single submitter ⚠
- p.Arg978Leu Single submitter ⚠
- p.Arg979Gln Single submitter ⚠
- p.Arg980Cys Single submitter ⚠
- p.Asn1172Asp Single submitter ⚠
- p.Asn305Ser Single submitter ⚠
- p.Asn462Ser Single submitter ⚠
- p.Asn708Asp Single submitter ⚠
- p.Asp1101Glu Single submitter ⚠
- p.Asp531Asn Single submitter ⚠
- p.Asp632His Single submitter ⚠
- p.Asp63Asn Single submitter ⚠
- p.Asp938Gly Single submitter ⚠
- p.Asp996Tyr Single submitter ⚠
- p.Cys327Ter Single submitter
- p.Cys441Arg Single submitter ⚠
- p.Gln665His Single submitter ⚠
- p.Glu1107Gln Single submitter ⚠
- p.Glu41Asp Single submitter ⚠
- p.Glu514Ala Single submitter ⚠
- p.Glu556Lys Single submitter ⚠
- p.Glu629Lys Single submitter ⚠
- p.Glu944Ala Single submitter ⚠
- p.Glu964Gln Single submitter ⚠
- p.Gly1043Ala Single submitter ⚠
- p.Gly1043Ser Single submitter ⚠
- p.Gly1179Arg Single submitter ⚠
- p.Gly620Glu Single submitter ⚠
- p.Gly735Cys Single submitter ⚠
- p.Gly735Ser Single submitter ⚠
- p.Gly960Asp Single submitter ⚠
- p.His625Arg Single submitter ⚠
- p.Ile1105Thr Single submitter ⚠
- p.Ile1146Val Single submitter ⚠
- p.Ile460Phe Single submitter ⚠
- p.Ile466Val Single submitter ⚠
- p.Leu750Phe Single submitter ⚠
- p.Leu994Pro Single submitter ⚠
- p.Lys331Gln Single submitter ⚠
- p.Met190Leu Single submitter ⚠
- p.Met236Val Single submitter ⚠
- p.Met607Val Single submitter ⚠
- p.Pro1072Arg Single submitter ⚠
- p.Pro111Leu Single submitter ⚠
- p.Pro130Leu Single submitter ⚠
- p.Pro491His Single submitter ⚠
- p.Pro590Ala Single submitter ⚠
- p.Pro691Leu Single submitter ⚠
- p.Pro993Leu Single submitter ⚠
- p.Pro993Thr Single submitter ⚠
- p.Ser1021Gly Single submitter ⚠
- p.Ser1021Thr Single submitter ⚠
- p.Ser1025Phe Single submitter ⚠
- p.Ser1045Gly Single submitter ⚠
- p.Ser1175Asn Single submitter ⚠
- p.Ser505Cys Single submitter ⚠
- p.Ser990Asn Single submitter ⚠
- p.Thr30Ala Single submitter ⚠
- p.Thr565Ser Single submitter ⚠
- p.Trp697Cys Single submitter ⚠
- p.Tyr139Cys Single submitter ⚠
- p.Tyr328Ser Single submitter ⚠
- p.Val1093Ile Single submitter ⚠
- p.Val138Met Single submitter ⚠
- p.Val447Met Single submitter ⚠
- p.Val464Met Single submitter ⚠
- p.Val647Met Single submitter ⚠
- p.Val85Ala Single submitter ⚠
- p.Val97Gly Single submitter ⚠