BRD3 — 80 ClinVar variants
All ClinVar germline BRD3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 67 flagged for review →
3 Benign · 7 Likely benign · 70 Uncertain significance
Full BRD3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 67
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 46
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- BRD3 p.Ala10Val Uncertain significance Single submitter
- BRD3 p.Ala14Val Uncertain significance Single submitter
- BRD3 p.Ala161Val Uncertain significance Single submitter
- BRD3 p.Ala173Thr Uncertain significance Single submitter
- BRD3 p.Ala173Val Uncertain significance Single submitter
- BRD3 p.Ala198Val Uncertain significance Single submitter
- BRD3 p.Ala206Thr Uncertain significance Single submitter
- BRD3 p.Ala206Val Uncertain significance Single submitter
- BRD3 p.Ala273Thr Uncertain significance Single submitter
- BRD3 p.Ala302Thr Uncertain significance Single submitter
- BRD3 p.Ala422Ser Uncertain significance Single submitter
- BRD3 p.Ala424Pro Uncertain significance Single submitter
- BRD3 p.Ala429Val Uncertain significance Single submitter
- BRD3 p.Ala430Val Uncertain significance Single submitter
- BRD3 p.Ala540Val Uncertain significance Single submitter
- BRD3 p.Arg260Gln Uncertain significance Single submitter
- BRD3 p.Arg607Lys Uncertain significance Single submitter
- BRD3 p.Asn116Ser Uncertain significance Single submitter
- BRD3 p.Asp269Tyr Uncertain significance Single submitter
- BRD3 p.Asp295Gly Uncertain significance Single submitter
- BRD3 p.Gln476Arg Uncertain significance Single submitter
- BRD3 p.Gly589Arg Uncertain significance Single submitter
- BRD3 p.Ile286Val Uncertain significance Single submitter
- BRD3 p.Lys307Arg Uncertain significance Single submitter
- BRD3 p.Lys520Glu Uncertain significance Single submitter
- BRD3 p.Lys520Thr Uncertain significance Single submitter
- BRD3 p.Pro13Leu Uncertain significance Single submitter
- BRD3 p.Pro149Ser Uncertain significance Single submitter
- BRD3 p.Pro16Leu Uncertain significance Single submitter
- BRD3 p.Pro182Thr Uncertain significance Single submitter
- BRD3 p.Pro194Ser Uncertain significance Single submitter
- BRD3 p.Pro234Leu Uncertain significance Single submitter
- BRD3 p.Pro23Ala Uncertain significance Single submitter
- BRD3 p.Pro264Leu Uncertain significance Single submitter
- BRD3 p.Pro265Leu Uncertain significance Single submitter
- BRD3 p.Pro423Leu Uncertain significance Single submitter
- BRD3 p.Ser191Phe Uncertain significance Single submitter
- BRD3 p.Ser263Leu Uncertain significance Single submitter
- BRD3 p.Thr199Pro Uncertain significance Single submitter
- BRD3 p.Thr209Met Uncertain significance Single submitter
- BRD3 p.Thr224Ile Uncertain significance Single submitter
- BRD3 p.Thr233Met Uncertain significance Single submitter
- BRD3 p.Thr545Met Uncertain significance Single submitter
- BRD3 p.Tyr561Cys Uncertain significance Single submitter
- BRD3 p.Val190Ile Uncertain significance Single submitter
- BRD3 p.Val229Met Uncertain significance Single submitter
Predictors split 21
The independent predictors disagree with each other — read with care.
- BRD3 p.Ala65Thr Uncertain significance Single submitter
- BRD3 p.Arg402Gln Uncertain significance Single submitter
- BRD3 p.Arg411Lys Uncertain significance Single submitter
- BRD3 p.Arg671Cys Uncertain significance Single submitter
- BRD3 p.Asn111Asp Uncertain significance Single submitter
- BRD3 p.Asn92Ser Uncertain significance Single submitter
- BRD3 p.Asp350Asn Uncertain significance Single submitter
- BRD3 p.Gly33Arg Uncertain significance Single submitter
- BRD3 p.Gly33Cys Uncertain significance Single submitter
- BRD3 p.Ile114Val Uncertain significance Single submitter
- BRD3 p.Ile77Val Uncertain significance Single submitter
- BRD3 p.Lys274Gln Uncertain significance Single submitter
- BRD3 p.Lys643Thr Uncertain significance Single submitter
-
BRD3 p.Met383Ile
Uncertain significance
Single submitter
primary ovarian failure
- BRD3 p.Met83Val Uncertain significance Single submitter
- BRD3 p.Pro22His Uncertain significance Single submitter
- BRD3 p.Pro23His Uncertain significance Single submitter
- BRD3 p.Ser609Ala Uncertain significance Single submitter
- BRD3 p.Thr49Met Uncertain significance Single submitter
- BRD3 p.Val213Phe Uncertain significance Single submitter
- BRD3 p.Val242Met Uncertain significance Single submitter
All BRD3 variants
Benign 3
- p.Thr15= Multiple submitters
- c.2065+3dup Single submitter
- p.His301= Single submitter
Likely benign 7
- c.1216-6C>T Single submitter
- p.Ala163Val Single submitter
- p.Ala166Thr Single submitter
- p.Ala437Thr Single submitter
- p.Lys655Arg Single submitter
- p.Thr545Ala Single submitter
- p.Val227Ile Single submitter
Uncertain significance 70
- c.1407+5G>A Single submitter
- p.Ala10Val Single submitter ⚠
- p.Ala14Val Single submitter ⚠
- p.Ala161Val Single submitter ⚠
- p.Ala173Thr Single submitter ⚠
- p.Ala173Val Single submitter ⚠
- p.Ala198Val Single submitter ⚠
- p.Ala206Thr Single submitter ⚠
- p.Ala206Val Single submitter ⚠
- p.Ala273Thr Single submitter ⚠
- p.Ala302Thr Single submitter ⚠
- p.Ala422Ser Single submitter ⚠
- p.Ala424Pro Single submitter ⚠
- p.Ala429Val Single submitter ⚠
- p.Ala430Val Single submitter ⚠
- p.Ala540Val Single submitter ⚠
- p.Ala65Thr Single submitter ⚠
- p.Arg260Gln Single submitter ⚠
- p.Arg402Gln Single submitter ⚠
- p.Arg411Lys Single submitter ⚠
- p.Arg607Lys Single submitter ⚠
- p.Arg671Cys Single submitter ⚠
- p.Asn111Asp Single submitter ⚠
- p.Asn116Ser Single submitter ⚠
- p.Asn92Ser Single submitter ⚠
- p.Asp269Tyr Single submitter ⚠
- p.Asp295Gly Single submitter ⚠
- p.Asp350Asn Single submitter ⚠
- p.Gln476Arg Single submitter ⚠
- p.Gly33Arg Single submitter ⚠
- p.Gly33Cys Single submitter ⚠
- p.Gly589Arg Single submitter ⚠
- p.Ile114Val Single submitter ⚠
- p.Ile286Val Single submitter ⚠
- p.Ile77Val Single submitter ⚠
- p.Lys274Gln Single submitter ⚠
- p.Lys307Arg Single submitter ⚠
- p.Lys520Glu Single submitter ⚠
- p.Lys520Thr Single submitter ⚠
- p.Lys643Thr Single submitter ⚠
- p.Met383Ile Single submitter primary ovarian failure ⚠
- p.Met83Val Single submitter ⚠
- p.Pro13Leu Single submitter ⚠
- p.Pro149Ser Single submitter ⚠
- p.Pro16Leu Single submitter ⚠
- p.Pro182Thr Single submitter ⚠
- p.Pro194Ser Single submitter ⚠
- p.Pro22His Single submitter ⚠
- p.Pro234Leu Single submitter ⚠
- p.Pro23Ala Single submitter ⚠
- p.Pro23His Single submitter ⚠
- p.Pro264Leu Single submitter ⚠
- p.Pro265Leu Single submitter ⚠
- p.Pro423Leu Single submitter ⚠
- p.Ser191Phe Single submitter ⚠
- p.Ser263Leu Single submitter ⚠
- p.Ser609Ala Single submitter ⚠
- p.Thr199Pro Single submitter ⚠
- p.Thr209Met Single submitter ⚠
- p.Thr224Ile Single submitter ⚠
- p.Thr233Met Single submitter ⚠
- p.Thr252Met Single submitter
- p.Thr49Met Single submitter ⚠
- p.Thr545Met Single submitter ⚠
- p.Tyr390Ter Single submitter
- p.Tyr561Cys Single submitter ⚠
- p.Val190Ile Single submitter ⚠
- p.Val213Phe Single submitter ⚠
- p.Val229Met Single submitter ⚠
- p.Val242Met Single submitter ⚠