BRD7 — 84 ClinVar variants
All ClinVar germline BRD7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 81 flagged for review →
1 Likely pathogenic · 4 Likely benign · 79 Uncertain significance
Full BRD7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 81
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 54
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- BRD7 p.Ala101Thr Uncertain significance Single submitter
- BRD7 p.Ala284Val Uncertain significance Single submitter
- BRD7 p.Arg254Gln Uncertain significance Single submitter
- BRD7 p.Arg276Lys Uncertain significance Single submitter
- BRD7 p.Arg84Lys Uncertain significance Single submitter
- BRD7 p.Arg96Gln Uncertain significance Single submitter
- BRD7 p.Asn53Ile Uncertain significance Single submitter
- BRD7 p.Asn591Asp Uncertain significance Single submitter
- BRD7 p.Asn626Lys Uncertain significance Single submitter
- BRD7 p.Asn99Ser Uncertain significance Single submitter
- BRD7 p.Asp189Asn Uncertain significance Single submitter
- BRD7 p.Asp261Gly Uncertain significance Single submitter
- BRD7 p.Asp54Glu Uncertain significance Single submitter
- BRD7 p.Cys107Arg Uncertain significance Single submitter
- BRD7 p.Gln128Arg Uncertain significance Single submitter
- BRD7 p.Gln256Arg Uncertain significance Single submitter
- BRD7 p.Gln315Arg Uncertain significance Single submitter
- BRD7 p.Gln337Arg Uncertain significance Single submitter
- BRD7 p.Gln337Glu Uncertain significance Single submitter
- BRD7 p.Gln598Glu Uncertain significance Single submitter
- BRD7 p.Gln72Arg Uncertain significance Single submitter
- BRD7 p.Glu102Gly Uncertain significance Single submitter
- BRD7 p.Glu17Asp Uncertain significance Single submitter
- BRD7 p.Glu339Lys Uncertain significance Single submitter
- BRD7 p.Gly43Arg Uncertain significance Single submitter
- BRD7 p.Gly69Glu Uncertain significance Single submitter
- BRD7 p.His13Gln Uncertain significance Single submitter
- BRD7 p.His472Leu Uncertain significance Single submitter
- BRD7 p.His489Asp Uncertain significance Single submitter
- BRD7 p.Ile171Met Uncertain significance Single submitter
- BRD7 p.Ile193Val Uncertain significance Single submitter
- BRD7 p.Leu125Ile Uncertain significance Single submitter
- BRD7 p.Leu318Val Uncertain significance Single submitter
- BRD7 p.Leu493Val Uncertain significance Single submitter
- BRD7 p.Leu510Val Uncertain significance Single submitter
- BRD7 p.Lys119Asn Uncertain significance Single submitter
- BRD7 p.Lys241Arg Uncertain significance Single submitter
- BRD7 p.Lys328Arg Uncertain significance Single submitter
- BRD7 p.Lys78Arg Uncertain significance Single submitter
- BRD7 p.Met170Val Uncertain significance Single submitter
- BRD7 p.Met459Leu Uncertain significance Single submitter
- BRD7 p.Met624Ile Uncertain significance Single submitter
- BRD7 p.Pro116Leu Uncertain significance Single submitter
- BRD7 p.Pro175Ala Uncertain significance Single submitter
- BRD7 p.Pro368Ser Uncertain significance Single submitter
- BRD7 p.Pro74Leu Uncertain significance Single submitter
- BRD7 p.Pro74Ser Uncertain significance Single submitter
- BRD7 p.Ser41Gly Uncertain significance Single submitter
- BRD7 p.Ser462Thr Uncertain significance Single submitter
- BRD7 p.Thr122Ile Uncertain significance Single submitter
- BRD7 p.Thr495Lys Uncertain significance Single submitter
- BRD7 p.Val131Ile Uncertain significance Single submitter
- BRD7 p.Val396Ile Uncertain significance Single submitter
- BRD7 p.Val529Ile Uncertain significance Single submitter
Predictors split 27
The independent predictors disagree with each other — read with care.
- BRD7 p.Ala520Val Uncertain significance Single submitter
- BRD7 p.Ala559Thr Uncertain significance Single submitter
- BRD7 p.Arg276Ile Uncertain significance Single submitter
- BRD7 p.Arg63Pro Uncertain significance Single submitter
- BRD7 p.Arg92Gln Uncertain significance Single submitter
- BRD7 p.Asn141Lys Uncertain significance Single submitter
- BRD7 p.Asp630Asn Uncertain significance Single submitter
- BRD7 p.Gln588Glu Uncertain significance Single submitter
- BRD7 p.Glu633Gly Uncertain significance Single submitter
- BRD7 p.Gly2Asp Uncertain significance Single submitter
- BRD7 p.Gly372Glu Uncertain significance Single submitter
- BRD7 p.Gly577Asp Uncertain significance Single submitter
- BRD7 p.His58Tyr Uncertain significance Single submitter
- BRD7 p.His5Gln Uncertain significance Single submitter
- BRD7 p.Leu136Val Uncertain significance Single submitter
- BRD7 p.Lys62Asn Uncertain significance Single submitter
- BRD7 p.Met247Thr Uncertain significance Single submitter
- BRD7 p.Met583Lys Uncertain significance Single submitter
- BRD7 p.Phe448Leu Uncertain significance Single submitter
- BRD7 p.Phe49Leu Likely benign Single submitter
- BRD7 p.Pro622Leu Uncertain significance Single submitter
- BRD7 p.Ser416Thr Uncertain significance Single submitter
- BRD7 p.Ser437Cys Uncertain significance Single submitter
- BRD7 p.Ser46Pro Uncertain significance Single submitter
- BRD7 p.Thr417Ser Uncertain significance Single submitter
- BRD7 p.Thr608Met Likely benign Single submitter
- BRD7 p.Val606Leu Uncertain significance Single submitter
All BRD7 variants
Likely pathogenic 1
- p.Arg612Ter No assertion criteria granular cell cancer
Likely benign 4
- p.Phe49Leu Single submitter ⚠
- p.Thr608Met Single submitter ⚠
- p.Val504Ile Single submitter
- p.Val623Ile Single submitter
Uncertain significance 79
- p.Ala101Thr Single submitter ⚠
- p.Ala284Val Single submitter ⚠
- p.Ala520Val Single submitter ⚠
- p.Ala559Thr Single submitter ⚠
- p.Arg254Gln Single submitter ⚠
- p.Arg276Ile Single submitter ⚠
- p.Arg276Lys Single submitter ⚠
- p.Arg63Pro Single submitter ⚠
- p.Arg84Lys Single submitter ⚠
- p.Arg92Gln Single submitter ⚠
- p.Arg96Gln Single submitter ⚠
- p.Asn141Lys Single submitter ⚠
- p.Asn53Ile Single submitter ⚠
- p.Asn591Asp Single submitter ⚠
- p.Asn626Lys Single submitter ⚠
- p.Asn99Ser Single submitter ⚠
- p.Asp189Asn Single submitter ⚠
- p.Asp261Gly Single submitter ⚠
- p.Asp54Glu Single submitter ⚠
- p.Asp630Asn Single submitter ⚠
- p.Cys107Arg Single submitter ⚠
- p.Gln128Arg Single submitter ⚠
- p.Gln256Arg Single submitter ⚠
- p.Gln315Arg Single submitter ⚠
- p.Gln337Arg Single submitter ⚠
- p.Gln337Glu Single submitter ⚠
- p.Gln588Glu Single submitter ⚠
- p.Gln598Glu Single submitter ⚠
- p.Gln72Arg Single submitter ⚠
- p.Glu102Gly Single submitter ⚠
- p.Glu17Asp Single submitter ⚠
- p.Glu339Lys Single submitter ⚠
- p.Glu633Gly Single submitter ⚠
- p.Gly2Asp Single submitter ⚠
- p.Gly372Glu Single submitter ⚠
- p.Gly43Arg Single submitter ⚠
- p.Gly577Asp Single submitter ⚠
- p.Gly69Glu Single submitter ⚠
- p.His13Gln Single submitter ⚠
- p.His472Leu Single submitter ⚠
- p.His489Asp Single submitter ⚠
- p.His58Tyr Single submitter ⚠
- p.His5Gln Single submitter ⚠
- p.Ile171Met Single submitter ⚠
- p.Ile193Val Single submitter ⚠
- p.Leu125Ile Single submitter ⚠
- p.Leu136Val Single submitter ⚠
- p.Leu318Val Single submitter ⚠
- p.Leu493Val Single submitter ⚠
- p.Leu510Val Single submitter ⚠
- p.Lys119Asn Single submitter ⚠
- p.Lys241Arg Single submitter ⚠
- p.Lys328Arg Single submitter ⚠
- p.Lys62Asn Single submitter ⚠
- p.Lys78Arg Single submitter ⚠
- p.Met170Val Single submitter ⚠
- p.Met247Thr Single submitter ⚠
- p.Met459Leu Single submitter ⚠
- p.Met583Lys Single submitter ⚠
- p.Met624Ile Single submitter ⚠
- p.Phe448Leu Single submitter ⚠
- p.Pro116Leu Single submitter ⚠
- p.Pro175Ala Single submitter ⚠
- p.Pro368Ser Single submitter ⚠
- p.Pro622Leu Single submitter ⚠
- p.Pro74Leu Single submitter ⚠
- p.Pro74Ser Single submitter ⚠
- p.Ser416Thr Single submitter ⚠
- p.Ser41Gly Single submitter ⚠
- p.Ser437Cys Single submitter ⚠
- p.Ser462Thr Single submitter ⚠
- p.Ser46Pro Single submitter ⚠
- p.Thr122Ile Single submitter ⚠
- p.Thr417Ser Single submitter ⚠
- p.Thr495Lys Single submitter ⚠
- p.Val131Ile Single submitter ⚠
- p.Val396Ile Single submitter ⚠
- p.Val529Ile Single submitter ⚠
- p.Val606Leu Single submitter ⚠