BRD8 — 126 ClinVar variants
All ClinVar germline BRD8 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 116 flagged for review →
3 Benign · 4 Likely benign · 119 Uncertain significance
Full BRD8 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 116
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 99
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- BRD8 p.Ala165Val Uncertain significance Single submitter
- BRD8 p.Ala211Thr Uncertain significance Single submitter
- BRD8 p.Ala264Val Uncertain significance Single submitter
- BRD8 p.Ala273Ser Uncertain significance Single submitter
- BRD8 p.Ala314Val Uncertain significance Single submitter
- BRD8 p.Ala331Thr Uncertain significance Single submitter
- BRD8 p.Ala437Thr Uncertain significance Single submitter
- BRD8 p.Ala553Val Uncertain significance Single submitter
- BRD8 p.Ala559Thr Uncertain significance Single submitter
- BRD8 p.Ala639Val Uncertain significance Single submitter
- BRD8 p.Ala937Val Uncertain significance Single submitter
- BRD8 p.Arg1161Gln Uncertain significance Single submitter
- BRD8 p.Arg1161Trp Uncertain significance Single submitter
- BRD8 p.Arg121Gln Uncertain significance Single submitter
- BRD8 p.Arg467Gln Uncertain significance Single submitter
- BRD8 p.Arg484Lys Uncertain significance Single submitter
- BRD8 p.Arg54His Uncertain significance Single submitter
- BRD8 p.Asp1095Asn Uncertain significance Single submitter
- BRD8 p.Asp1099Ala Uncertain significance Single submitter
- BRD8 p.Asp1100Glu Uncertain significance Single submitter
- BRD8 p.Asp1186Gly Uncertain significance Single submitter
- BRD8 p.Asp1212Glu Uncertain significance Single submitter
- BRD8 p.Asp190Gly Uncertain significance Single submitter
- BRD8 p.Asp337Asn Uncertain significance Single submitter
- BRD8 p.Asp543Asn Uncertain significance Single submitter
- BRD8 p.Asp872Val Uncertain significance Single submitter
- BRD8 p.Gln1032Arg Uncertain significance Single submitter
- BRD8 p.Gln1052Pro Uncertain significance Single submitter
- BRD8 p.Gln1063Arg Uncertain significance Single submitter
- BRD8 p.Gln1098Arg Uncertain significance Single submitter
- BRD8 p.Gln130Glu Uncertain significance Single submitter
- BRD8 p.Gln453Glu Uncertain significance Single submitter
- BRD8 p.Glu1042Lys Uncertain significance Single submitter
- BRD8 p.Glu1050Gln Uncertain significance Single submitter
- BRD8 p.Glu1068Lys Uncertain significance Single submitter
- BRD8 p.Glu219Asp Uncertain significance Single submitter
- BRD8 p.Glu369Gln Uncertain significance Single submitter
- BRD8 p.Glu370Asp Uncertain significance Single submitter
- BRD8 p.Glu393Ala Uncertain significance Single submitter
- BRD8 p.Glu538Ala Uncertain significance Single submitter
- BRD8 p.Glu598Asp Uncertain significance Single submitter
- BRD8 p.Glu911Gly Uncertain significance Single submitter
- BRD8 p.Glu966Lys Uncertain significance Single submitter
- BRD8 p.Glu980Lys Uncertain significance Single submitter
- BRD8 p.Gly1139Val Uncertain significance Single submitter
- BRD8 p.Gly1216Val Uncertain significance Single submitter
- BRD8 p.Gly494Ala Uncertain significance Single submitter
- BRD8 p.Gly927Glu Uncertain significance Single submitter
- BRD8 p.His496Arg Uncertain significance Single submitter
- BRD8 p.Ile189Val Uncertain significance Single submitter
- BRD8 p.Ile463Phe Uncertain significance Single submitter
- BRD8 p.Ile519Val Uncertain significance Single submitter
- BRD8 p.Ile556Val Uncertain significance Single submitter
- BRD8 p.Ile593Thr Uncertain significance Single submitter
- BRD8 p.Ile673Val Uncertain significance Single submitter
- BRD8 p.Ile984Thr Uncertain significance Single submitter
- BRD8 p.Leu1084Ile Uncertain significance Single submitter
- BRD8 p.Leu227Val Uncertain significance Single submitter
- BRD8 p.Leu240Pro Uncertain significance Single submitter
- BRD8 p.Lys1011Glu Uncertain significance Single submitter
- BRD8 p.Lys109Thr Uncertain significance Single submitter
- BRD8 p.Met1060Val Uncertain significance Single submitter
- BRD8 p.Met208Val Uncertain significance Single submitter
- BRD8 p.Met534Val Uncertain significance Single submitter
- BRD8 p.Met583Ile Uncertain significance Single submitter
- BRD8 p.Met849Val Uncertain significance Single submitter
- BRD8 p.Met957Leu Uncertain significance Single submitter
- BRD8 p.Pro176Thr Uncertain significance Single submitter
- BRD8 p.Pro252Ser Uncertain significance Single submitter
- BRD8 p.Pro536Leu Uncertain significance Single submitter
- BRD8 p.Pro536Ser Uncertain significance Single submitter
- BRD8 p.Pro78Leu Uncertain significance Single submitter
- BRD8 p.Pro917Leu Uncertain significance Single submitter
- BRD8 p.Ser1038Asn Uncertain significance Single submitter
- BRD8 p.Ser1219Cys Uncertain significance Single submitter
- BRD8 p.Ser12Gly Uncertain significance Single submitter
- BRD8 p.Ser354Ala Uncertain significance Single submitter
- BRD8 p.Ser361Tyr Uncertain significance Single submitter
- BRD8 p.Ser579Phe Uncertain significance Single submitter
- BRD8 p.Ser610Ala Uncertain significance Single submitter
- BRD8 p.Ser916Thr Uncertain significance Single submitter
- BRD8 p.Ser931Thr Uncertain significance Single submitter
- BRD8 p.Thr16Pro Uncertain significance Single submitter
- BRD8 p.Thr207Ala Uncertain significance Single submitter
- BRD8 p.Thr207Ile Uncertain significance Single submitter
- BRD8 p.Thr212Ala Uncertain significance Single submitter
- BRD8 p.Thr490Ala Uncertain significance Single submitter
- BRD8 p.Thr5Met Uncertain significance Single submitter
- BRD8 p.Tyr1056His Uncertain significance Single submitter
- BRD8 p.Val1021Leu Uncertain significance Single submitter
- BRD8 p.Val340Asp Uncertain significance Single submitter
- BRD8 p.Val345Gly Uncertain significance Single submitter
- BRD8 p.Val499Leu Uncertain significance Single submitter
- BRD8 p.Val518Leu Uncertain significance Single submitter
- BRD8 p.Val557Ile Uncertain significance Single submitter
- BRD8 p.Val574Ala Uncertain significance Single submitter
- BRD8 p.Val865Ile Uncertain significance Single submitter
- BRD8 p.Val898Leu Uncertain significance Single submitter
- BRD8 p.Val926Phe Uncertain significance Single submitter
Predictors split 17
The independent predictors disagree with each other — read with care.
- BRD8 p.Ala684Thr Uncertain significance Single submitter
- BRD8 p.Arg1170Gln Uncertain significance Single submitter
- BRD8 p.Asp356Glu Uncertain significance Single submitter
- BRD8 p.Glu17Asp Uncertain significance Single submitter
- BRD8 p.His63Asn Uncertain significance Single submitter
- BRD8 p.Lys368Glu Uncertain significance Single submitter
- BRD8 p.Met1118Ile Uncertain significance Single submitter
- BRD8 p.Met362Ile Uncertain significance Single submitter
- BRD8 p.Pro1131Ala Benign Single submitter
- BRD8 p.Ser1152Arg Uncertain significance Single submitter
- BRD8 p.Ser334Arg Uncertain significance Single submitter
- BRD8 p.Ser66Phe Uncertain significance Single submitter
- BRD8 p.Thr1151Ile Uncertain significance Single submitter
- BRD8 p.Thr163Ile Uncertain significance Single submitter
- BRD8 p.Val480Gly Uncertain significance Single submitter
- BRD8 p.Val89Ala Uncertain significance Single submitter
- BRD8 p.Val92Leu Uncertain significance Single submitter
All BRD8 variants
Benign 3
- p.Leu1106Val Single submitter
- p.Leu896Pro Single submitter
- p.Pro1131Ala Single submitter ⚠
Likely benign 4
- c.643-506A>G Single submitter
- p.Arg1197Gln Single submitter
- p.Ile248Met Single submitter
- p.Met1060Thr Single submitter
Uncertain significance 119
- p.Ala165Val Single submitter ⚠
- p.Ala211Thr Single submitter ⚠
- p.Ala264Val Single submitter ⚠
- p.Ala273Ser Single submitter ⚠
- p.Ala314Val Single submitter ⚠
- p.Ala331Thr Single submitter ⚠
- p.Ala437Thr Single submitter ⚠
- p.Ala553Val Single submitter ⚠
- p.Ala559Thr Single submitter ⚠
- p.Ala639Val Single submitter ⚠
- p.Ala684Thr Single submitter ⚠
- p.Ala937Val Single submitter ⚠
- p.Arg1161Gln Single submitter ⚠
- p.Arg1161Trp Single submitter ⚠
- p.Arg1170Gln Single submitter ⚠
- p.Arg1170Gly Single submitter
- p.Arg121Gln Single submitter ⚠
- p.Arg467Gln Single submitter ⚠
- p.Arg484Lys Single submitter ⚠
- p.Arg54His Single submitter ⚠
- p.Arg802Gln Single submitter
- p.Asp1095Asn Single submitter ⚠
- p.Asp1099Ala Single submitter ⚠
- p.Asp1100Glu Single submitter ⚠
- p.Asp1186Gly Single submitter ⚠
- p.Asp1212Glu Single submitter ⚠
- p.Asp190Gly Single submitter ⚠
- p.Asp337Asn Single submitter ⚠
- p.Asp356Glu Single submitter ⚠
- p.Asp543Asn Single submitter ⚠
- p.Asp872Val Single submitter ⚠
- p.Gln1032Arg Single submitter ⚠
- p.Gln1052Pro Single submitter ⚠
- p.Gln1063Arg Single submitter ⚠
- p.Gln1098Arg Single submitter ⚠
- p.Gln130Glu Single submitter ⚠
- p.Gln453Glu Single submitter ⚠
- p.Glu1042Lys Single submitter ⚠
- p.Glu1050Gln Single submitter ⚠
- p.Glu1068Lys Single submitter ⚠
- p.Glu17Asp Single submitter ⚠
- p.Glu219Asp Single submitter ⚠
- p.Glu369Gln Single submitter ⚠
- p.Glu370Asp Single submitter ⚠
- p.Glu393Ala Single submitter ⚠
- p.Glu538Ala Single submitter ⚠
- p.Glu598Asp Single submitter ⚠
- p.Glu911Gly Single submitter ⚠
- p.Glu966Lys Single submitter ⚠
- p.Glu980Lys Single submitter ⚠
- p.Gly1139Val Single submitter ⚠
- p.Gly1216Val Single submitter ⚠
- p.Gly494Ala Single submitter ⚠
- p.Gly927Glu Single submitter ⚠
- p.His496Arg Single submitter ⚠
- p.His63Asn Single submitter ⚠
- p.Ile189Val Single submitter ⚠
- p.Ile463Phe Single submitter ⚠
- p.Ile519Val Single submitter ⚠
- p.Ile556Val Single submitter ⚠
- p.Ile593Thr Single submitter ⚠
- p.Ile673Val Single submitter ⚠
- p.Ile984Thr Single submitter ⚠
- p.Leu1084Ile Single submitter ⚠
- p.Leu227Val Single submitter ⚠
- p.Leu240Pro Single submitter ⚠
- p.Lys1011Glu Single submitter ⚠
- p.Lys109Thr Single submitter ⚠
- p.Lys123Gln Single submitter
- p.Lys368Glu Single submitter ⚠
- p.Met1060Val Single submitter ⚠
- p.Met1118Ile Single submitter ⚠
- p.Met208Val Single submitter ⚠
- p.Met362Ile Single submitter ⚠
- p.Met534Val Single submitter ⚠
- p.Met583Ile Single submitter ⚠
- p.Met849Val Single submitter ⚠
- p.Met957Leu Single submitter ⚠
- p.Pro176Thr Single submitter ⚠
- p.Pro252Ser Single submitter ⚠
- p.Pro536Leu Single submitter ⚠
- p.Pro536Ser Single submitter ⚠
- p.Pro78Leu Single submitter ⚠
- p.Pro917Leu Single submitter ⚠
- p.Ser1038Asn Single submitter ⚠
- p.Ser1152Arg Single submitter ⚠
- p.Ser1219Cys Single submitter ⚠
- p.Ser12Gly Single submitter ⚠
- p.Ser334Arg Single submitter ⚠
- p.Ser354Ala Single submitter ⚠
- p.Ser361Tyr Single submitter ⚠
- p.Ser579Phe Single submitter ⚠
- p.Ser610Ala Single submitter ⚠
- p.Ser66Phe Single submitter ⚠
- p.Ser916Thr Single submitter ⚠
- p.Ser931Thr Single submitter ⚠
- p.Thr1151Ile Single submitter ⚠
- p.Thr163Ile Single submitter ⚠
- p.Thr16Pro Single submitter ⚠
- p.Thr207Ala Single submitter ⚠
- p.Thr207Ile Single submitter ⚠
- p.Thr212Ala Single submitter ⚠
- p.Thr490Ala Single submitter ⚠
- p.Thr5Met Single submitter ⚠
- p.Thr756Ala Single submitter
- p.Tyr1056His Single submitter ⚠
- p.Val1021Leu Single submitter ⚠
- p.Val340Asp Single submitter ⚠
- p.Val345Gly Single submitter ⚠
- p.Val480Gly Single submitter ⚠
- p.Val499Leu Single submitter ⚠
- p.Val518Leu Single submitter ⚠
- p.Val557Ile Single submitter ⚠
- p.Val574Ala Single submitter ⚠
- p.Val865Ile Single submitter ⚠
- p.Val898Leu Single submitter ⚠
- p.Val89Ala Single submitter ⚠
- p.Val926Phe Single submitter ⚠
- p.Val92Leu Single submitter ⚠