BRD9 — 99 ClinVar variants

All ClinVar germline BRD9 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 85 flagged for review →

2 Benign · 9 Likely benign · 88 Uncertain significance

Full BRD9 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 85

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 74

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 11

The independent predictors disagree with each other — read with care.

All BRD9 variants

Benign 2

c.1526-6A>G Multiple submitters
p.Pro272= Multiple submitters

Likely benign 9

c.1272-6C>T Single submitter
p.Ala128= Single submitter
p.Ala134= Single submitter
p.Asn246Ser Single submitter
p.Gly105= Single submitter
p.Lys70= Single submitter
p.Ser278= Single submitter
p.Ser520Gly Single submitter
p.Val475Ala Single submitter

Uncertain significance 88

p.Ala10Asp Single submitter ⚠
p.Ala20Gly Single submitter ⚠
p.Ala232Thr Single submitter ⚠
p.Ala306Thr Single submitter ⚠
p.Ala346Thr Single submitter ⚠
p.Ala537Val Single submitter ⚠
p.Arg130Gln Single submitter ⚠
p.Arg150His Single submitter
p.Arg311Gln Single submitter ⚠
p.Arg311Trp Single submitter ⚠
p.Arg313Gly Single submitter ⚠
p.Arg377Lys Single submitter ⚠
p.Arg569Cys Single submitter ⚠
p.Arg569His Single submitter ⚠
p.Arg85Lys Single submitter ⚠
p.Arg98Thr Single submitter ⚠
p.Asn394Tyr Single submitter ⚠
p.Asn523Thr Single submitter ⚠
p.Asn549Ser Single submitter ⚠
p.Asn555Thr Single submitter ⚠
p.Asp108Val Single submitter ⚠
p.Asp188Asn Single submitter ⚠
p.Asp312His Single submitter ⚠
p.Asp345Glu Single submitter ⚠
p.Asp347Tyr Single submitter ⚠
p.Asp400Asn Single submitter ⚠
p.Asp415Asn Single submitter ⚠
p.Asp415Val Single submitter ⚠
p.Asp442Glu Single submitter ⚠
p.Asp477Val Single submitter ⚠
p.Asp501Ala Single submitter ⚠
p.Asp581Asn Single submitter ⚠
p.Gln142Arg Single submitter
p.Gln532Arg Single submitter ⚠
p.Gln561His Single submitter ⚠
p.Glu117Val Single submitter ⚠
p.Glu137Lys Single submitter ⚠
p.Glu17Gly Single submitter ⚠
p.Glu194Lys Single submitter ⚠
p.Glu296Lys Single submitter ⚠
p.Glu297Gln Single submitter ⚠
p.Glu309Lys Single submitter ⚠
p.Glu375Asp Single submitter ⚠
p.Glu405Lys Single submitter ⚠
p.Glu526Asp Single submitter ⚠
p.Glu75Lys Single submitter ⚠
p.Glu90Lys Single submitter ⚠
p.Gly330Arg Single submitter ⚠
p.Gly399Arg Single submitter ⚠
p.Gly399Asp Single submitter ⚠
p.Gly414Arg Single submitter ⚠
p.Gly542Cys Single submitter ⚠
p.His179Arg Single submitter ⚠
p.His352Gln Single submitter ⚠
p.His562Tyr Single submitter ⚠
p.His58Tyr Single submitter ⚠
p.Ile190Thr Single submitter ⚠
p.Ile277Thr Single submitter ⚠
p.Ile502Phe Single submitter ⚠
p.Leu318Phe Single submitter ⚠
p.Leu363Val Single submitter ⚠
p.Leu80Val Single submitter ⚠
p.Lys270Arg Single submitter ⚠
p.Lys510Arg Single submitter ⚠
p.Met181Val Single submitter ⚠
p.Met323Val Single submitter ⚠
p.Met467Val Single submitter ⚠
p.Met492Ile Single submitter ⚠
p.Pro112Arg Single submitter ⚠
p.Pro122Ser Single submitter ⚠
p.Pro272Leu Single submitter ⚠
p.Pro353Ala Single submitter ⚠
p.Ser273Arg Single submitter ⚠
p.Ser360Pro Single submitter ⚠
p.Ser403Leu Single submitter ⚠
p.Ser453Phe Single submitter ⚠
p.Ser499Phe Single submitter ⚠
p.Ser503Phe Single submitter ⚠
p.Ser568Phe Single submitter ⚠
p.Thr103Arg Single submitter ⚠
p.Thr249Arg Single submitter ⚠
p.Thr291Met Single submitter ⚠
p.Thr369Met Single submitter ⚠
p.Thr417Arg Single submitter
p.Tyr583Cys Single submitter ⚠
p.Val251Phe Single submitter ⚠
p.Val338Met Single submitter ⚠
p.Val475Leu Single submitter ⚠