BRDT — 118 ClinVar variants
All ClinVar germline BRDT variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 107 flagged for review →
1 Pathogenic · 1 Likely pathogenic · 1 Benign · 9 Likely benign · 106 Uncertain significance
Full BRDT gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 107
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 67
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- BRDT p.Ala241Val Uncertain significance Single submitter
- BRDT p.Ala405Thr Uncertain significance Single submitter
- BRDT p.Ala898Gly Uncertain significance Single submitter
- BRDT p.Arg54His Uncertain significance Single submitter
- BRDT p.Arg636Gln Uncertain significance Single submitter
- BRDT p.Arg82Cys Uncertain significance Single submitter
- BRDT p.Arg847Gln Uncertain significance Single submitter
- BRDT p.Asn302His Uncertain significance Single submitter
- BRDT p.Asn403Asp Uncertain significance Single submitter
- BRDT p.Asn403His Uncertain significance Single submitter
- BRDT p.Asn679Ser Uncertain significance Single submitter
- BRDT p.Asn733Lys Uncertain significance Single submitter
- BRDT p.Asn882Asp Uncertain significance Single submitter
- BRDT p.Asn882Ser Uncertain significance Single submitter
- BRDT p.Asp113Gly Uncertain significance Single submitter
- BRDT p.Asp340His Uncertain significance Single submitter
- BRDT p.Cys884Arg Uncertain significance Single submitter
- BRDT p.Glu144Gln Uncertain significance Single submitter
- BRDT p.Glu230Gly Uncertain significance Single submitter
- BRDT p.Glu400Gly Uncertain significance Single submitter
- BRDT p.Glu453Asp Uncertain significance Single submitter
- BRDT p.Glu787Lys Uncertain significance Single submitter
- BRDT p.Glu874Gln Uncertain significance Single submitter
- BRDT p.Gly498Ser Uncertain significance Single submitter
- BRDT p.Gly763Asp Uncertain significance Single submitter
-
BRDT p.Gly928Asp
Uncertain significance
Single submitter
spermatogenic failure 21
- BRDT p.His288Pro Uncertain significance Single submitter
- BRDT p.Ile10Val Uncertain significance Single submitter
- BRDT p.Ile245Leu Uncertain significance Single submitter
- BRDT p.Ile378Thr Uncertain significance Single submitter
- BRDT p.Ile389Thr Uncertain significance Single submitter
- BRDT p.Ile695Val Uncertain significance Single submitter
- BRDT p.Ile798Val Uncertain significance Single submitter
- BRDT p.Ile846Thr Uncertain significance Single submitter
- BRDT p.Leu280Pro Uncertain significance Single submitter
- BRDT p.Leu904Phe Uncertain significance Single submitter
- BRDT p.Leu934Arg Uncertain significance Single submitter
- BRDT p.Lys238Ile Uncertain significance Single submitter
- BRDT p.Lys421Met Uncertain significance Single submitter
- BRDT p.Lys617Asn Uncertain significance Single submitter
- BRDT p.Lys751Arg Uncertain significance Single submitter
- BRDT p.Lys839Arg Uncertain significance Single submitter
- BRDT p.Lys901Asn Uncertain significance Single submitter
- BRDT p.Pro165His Uncertain significance Single submitter
- BRDT p.Pro165Ser Uncertain significance Single submitter
- BRDT p.Pro4Ser Uncertain significance Single submitter
- BRDT p.Pro726Leu Uncertain significance Single submitter
- BRDT p.Pro760Leu Uncertain significance Single submitter
- BRDT p.Pro760Ser Uncertain significance Single submitter
- BRDT p.Ser596Leu Uncertain significance Single submitter
- BRDT p.Ser615Cys Uncertain significance Single submitter
- BRDT p.Ser615Pro Uncertain significance Single submitter
- BRDT p.Ser778Ala Uncertain significance Single submitter
- BRDT p.Ser808Asn Uncertain significance Single submitter
- BRDT p.Ser902Thr Uncertain significance Single submitter
- BRDT p.Thr391Arg Uncertain significance Single submitter
- BRDT p.Thr718Ile Uncertain significance Single submitter
- BRDT p.Tyr261His Uncertain significance Single submitter
- BRDT p.Tyr335Asn Uncertain significance Single submitter
- BRDT p.Tyr34His Uncertain significance Single submitter
- BRDT p.Val197Gly Uncertain significance Single submitter
- BRDT p.Val207Ile Uncertain significance Single submitter
- BRDT p.Val263Ile Uncertain significance Single submitter
- BRDT p.Val443Ile Uncertain significance Single submitter
- BRDT p.Val443Leu Uncertain significance Single submitter
- BRDT p.Val687Gly Uncertain significance Single submitter
- BRDT p.Val813Ala Uncertain significance Single submitter
Predictors split 40
The independent predictors disagree with each other — read with care.
- BRDT p.Arg419Gln Uncertain significance Single submitter
- BRDT p.Arg422Cys Uncertain significance Single submitter
- BRDT p.Arg422Leu Uncertain significance Single submitter
- BRDT p.Arg446Cys Uncertain significance Single submitter
- BRDT p.Arg910His Uncertain significance Single submitter
- BRDT p.Asn449Tyr Uncertain significance Single submitter
- BRDT p.Asn72Tyr Uncertain significance Single submitter
- BRDT p.Asp216Tyr Uncertain significance Single submitter
- BRDT p.Asp327Gly Uncertain significance Single submitter
- BRDT p.Asp414Tyr Uncertain significance Single submitter
- BRDT p.Asp823Tyr Uncertain significance Single submitter
- BRDT p.Gln517Lys Uncertain significance Single submitter
- BRDT p.Gln843Arg Uncertain significance Single submitter
- BRDT p.Ile552Val Uncertain significance Single submitter
- BRDT p.Ile834Thr Uncertain significance Single submitter
- BRDT p.Ile95Thr Uncertain significance Single submitter
- BRDT p.Leu117Phe Uncertain significance Single submitter
- BRDT p.Leu319Ile Uncertain significance Single submitter
- BRDT p.Lys286Arg Uncertain significance Single submitter
- BRDT p.Lys350Glu Uncertain significance Single submitter
- BRDT p.Lys71Thr Uncertain significance Single submitter
- BRDT p.Lys855Met Uncertain significance Single submitter
- BRDT p.Met283Ile Uncertain significance Single submitter
- BRDT p.Met326Ile Uncertain significance Single submitter
- BRDT p.Met344Ile Uncertain significance Single submitter
- BRDT p.Phe673Leu Uncertain significance Single submitter
- BRDT p.Phe98Leu Uncertain significance Single submitter
- BRDT p.Pro377Arg Uncertain significance Single submitter
- BRDT p.Pro377Thr Uncertain significance Single submitter
- BRDT p.Ser185Phe Uncertain significance Single submitter
- BRDT p.Ser635Cys Uncertain significance Single submitter
- BRDT p.Ser645Asn Uncertain significance Single submitter
- BRDT p.Ser646Gly Uncertain significance Single submitter
- BRDT p.Ser92Leu Uncertain significance Single submitter
- BRDT p.Thr360Ile Uncertain significance Single submitter
- BRDT p.Thr625Met Uncertain significance Single submitter
- BRDT p.Tyr34Cys Uncertain significance Single submitter
- BRDT p.Val191Met Likely benign Single submitter
- BRDT p.Val312Phe Uncertain significance Single submitter
- BRDT p.Val38Ala Uncertain significance Single submitter
All BRDT variants
Pathogenic 1
- p.Asp513fs Single submitter primary ovarian failure
Likely pathogenic 1
- p.Gln795Ter Single submitter spermatogenic failure 21
Benign 1
- p.Glu649= Single submitter
Likely benign 9
- p.Arg274Lys Single submitter
- p.Arg446His Single submitter
- p.Lys751Glu Single submitter
- p.Val191Met Single submitter ⚠
- p.Val240Ala Single submitter
- p.Val312Ile Single submitter
- p.Val703Ile Single submitter
- c.2003-5T>G No assertion criteria BRDT-related disorder
- p.Asn403= No assertion criteria BRDT-related disorder
Uncertain significance 106
- p.Ala241Val Single submitter ⚠
- p.Ala405Thr Single submitter ⚠
- p.Ala898Gly Single submitter ⚠
- p.Arg419Gln Single submitter ⚠
- p.Arg422Cys Single submitter ⚠
- p.Arg422Leu Single submitter ⚠
- p.Arg446Cys Single submitter ⚠
- p.Arg54His Single submitter ⚠
- p.Arg636Gln Single submitter ⚠
- p.Arg82Cys Single submitter ⚠
- p.Arg847Gln Single submitter ⚠
- p.Arg910His Single submitter ⚠
- p.Asn302His Single submitter ⚠
- p.Asn403Asp Single submitter ⚠
- p.Asn403His Single submitter ⚠
- p.Asn449Tyr Single submitter ⚠
- p.Asn679Ser Single submitter ⚠
- p.Asn72Tyr Single submitter ⚠
- p.Asn733Lys Single submitter ⚠
- p.Asn882Asp Single submitter ⚠
- p.Asn882Ser Single submitter ⚠
- p.Asp113Gly Single submitter ⚠
- p.Asp216Tyr Single submitter ⚠
- p.Asp327Gly Single submitter ⚠
- p.Asp340His Single submitter ⚠
- p.Asp414Tyr Single submitter ⚠
- p.Asp823Tyr Single submitter ⚠
- p.Cys884Arg Single submitter ⚠
- p.Gln517Lys Single submitter ⚠
- p.Gln843Arg Single submitter ⚠
- p.Glu144Gln Single submitter ⚠
- p.Glu230Gly Single submitter ⚠
- p.Glu400Gly Single submitter ⚠
- p.Glu453Asp Single submitter ⚠
- p.Glu787Lys Single submitter ⚠
- p.Glu874Gln Single submitter ⚠
- p.Gly498Ser Single submitter ⚠
- p.Gly763Asp Single submitter ⚠
- p.Gly928Asp Single submitter spermatogenic failure 21 ⚠
- p.His288Pro Single submitter ⚠
- p.Ile10Val Single submitter ⚠
- p.Ile245Leu Single submitter ⚠
- p.Ile378Thr Single submitter ⚠
- p.Ile389Thr Single submitter ⚠
- p.Ile552Val Single submitter ⚠
- p.Ile695Val Single submitter ⚠
- p.Ile798Val Single submitter ⚠
- p.Ile834Thr Single submitter ⚠
- p.Ile846Thr Single submitter ⚠
- p.Ile95Thr Single submitter ⚠
- p.Leu117Phe Single submitter ⚠
- p.Leu280Pro Single submitter ⚠
- p.Leu319Ile Single submitter ⚠
- p.Leu904Phe Single submitter ⚠
- p.Leu934Arg Single submitter ⚠
- p.Lys238Ile Single submitter ⚠
- p.Lys286Arg Single submitter ⚠
- p.Lys350Glu Single submitter ⚠
- p.Lys421Met Single submitter ⚠
- p.Lys617Asn Single submitter ⚠
- p.Lys71Thr Single submitter ⚠
- p.Lys751Arg Single submitter ⚠
- p.Lys839Arg Single submitter ⚠
- p.Lys855Met Single submitter ⚠
- p.Lys901Asn Single submitter ⚠
- p.Met283Ile Single submitter ⚠
- p.Met326Ile Single submitter ⚠
- p.Met344Ile Single submitter ⚠
- p.Phe673Leu Single submitter ⚠
- p.Phe98Leu Single submitter ⚠
- p.Pro165His Single submitter ⚠
- p.Pro165Ser Single submitter ⚠
- p.Pro377Arg Single submitter ⚠
- p.Pro377Thr Single submitter ⚠
- p.Pro4Ser Single submitter ⚠
- p.Pro726Leu Single submitter ⚠
- p.Pro760Leu Single submitter ⚠
- p.Pro760Ser Single submitter ⚠
- p.Ser185Phe Single submitter ⚠
- p.Ser596Leu Single submitter ⚠
- p.Ser615Cys Single submitter ⚠
- p.Ser615Pro Single submitter ⚠
- p.Ser635Cys Single submitter ⚠
- p.Ser645Asn Single submitter ⚠
- p.Ser646Gly Single submitter ⚠
- p.Ser778Ala Single submitter ⚠
- p.Ser808Asn Single submitter ⚠
- p.Ser902Thr Single submitter ⚠
- p.Ser92Leu Single submitter ⚠
- p.Thr360Ile Single submitter ⚠
- p.Thr391Arg Single submitter ⚠
- p.Thr625Met Single submitter ⚠
- p.Thr718Ile Single submitter ⚠
- p.Tyr261His Single submitter ⚠
- p.Tyr335Asn Single submitter ⚠
- p.Tyr34Cys Single submitter ⚠
- p.Tyr34His Single submitter ⚠
- p.Val197Gly Single submitter ⚠
- p.Val207Ile Single submitter ⚠
- p.Val263Ile Single submitter ⚠
- p.Val312Phe Single submitter ⚠
- p.Val38Ala Single submitter ⚠
- p.Val443Ile Single submitter ⚠
- p.Val443Leu Single submitter ⚠
- p.Val687Gly Single submitter ⚠
- p.Val813Ala Single submitter ⚠