BRF2 — 68 ClinVar variants
All ClinVar germline BRF2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 65 flagged for review →
1 Likely benign · 67 Uncertain significance
Full BRF2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 65
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 49
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- BRF2 p.Ala185Pro Uncertain significance Single submitter
- BRF2 p.Ala262Val Uncertain significance Single submitter
- BRF2 p.Ala317Gly Uncertain significance Single submitter
- BRF2 p.Ala352Ser Uncertain significance Single submitter
- BRF2 p.Ala405Ser Uncertain significance Single submitter
- BRF2 p.Arg127Gln Uncertain significance Single submitter
- BRF2 p.Arg203Gln Uncertain significance Single submitter
- BRF2 p.Arg265His Uncertain significance Single submitter
- BRF2 p.Arg275Leu Uncertain significance Single submitter
- BRF2 p.Arg304Gly Uncertain significance Single submitter
- BRF2 p.Arg304His Uncertain significance Single submitter
- BRF2 p.Arg309His Uncertain significance Single submitter
- BRF2 p.Arg313Trp Uncertain significance Single submitter
- BRF2 p.Arg368Gln Uncertain significance Single submitter
- BRF2 p.Arg394Pro Uncertain significance Single submitter
- BRF2 p.Arg67Cys Uncertain significance Single submitter
- BRF2 p.Arg74Gln Uncertain significance Single submitter
- BRF2 p.Asn212Ser Uncertain significance Single submitter
- BRF2 p.Asp46Glu Uncertain significance Single submitter
- BRF2 p.Gln206His Uncertain significance Single submitter
- BRF2 p.Gln331Leu Uncertain significance Single submitter
- BRF2 p.Gln410Arg Uncertain significance Single submitter
- BRF2 p.Glu61Gly Uncertain significance Single submitter
- BRF2 p.Gly330Arg Uncertain significance Single submitter
- BRF2 p.Gly334Glu Uncertain significance Single submitter
- BRF2 p.Gly344Ser Uncertain significance Single submitter
- BRF2 p.Leu307Val Uncertain significance Single submitter
- BRF2 p.Leu358Phe Uncertain significance Single submitter
- BRF2 p.Lys174Asn Uncertain significance Single submitter
- BRF2 p.Met205Val Uncertain significance Single submitter
- BRF2 p.Pro224Ala Uncertain significance Single submitter
- BRF2 p.Pro2Ser Uncertain significance Single submitter
- BRF2 p.Pro327Leu Uncertain significance Single submitter
- BRF2 p.Pro371Arg Uncertain significance Single submitter
- BRF2 p.Pro373His Uncertain significance Single submitter
- BRF2 p.Pro396Ser Uncertain significance Single submitter
- BRF2 p.Ser104Pro Uncertain significance Single submitter
- BRF2 p.Ser166Phe Uncertain significance Single submitter
- BRF2 p.Thr140Met Uncertain significance Single submitter
- BRF2 p.Thr377Ile Uncertain significance Single submitter
- BRF2 p.Thr413Met Uncertain significance Single submitter
- BRF2 p.Thr54Ser Uncertain significance Single submitter
- BRF2 p.Thr88Ile Uncertain significance Single submitter
- BRF2 p.Val116Met Uncertain significance Single submitter
- BRF2 p.Val194Met Uncertain significance Single submitter
- BRF2 p.Val225Ile Uncertain significance Single submitter
- BRF2 p.Val338Gly Uncertain significance Single submitter
- BRF2 p.Val35Leu Uncertain significance Single submitter
- BRF2 p.Val39Phe Uncertain significance Single submitter
Predictors split 16
The independent predictors disagree with each other — read with care.
- BRF2 p.Ala109Thr Uncertain significance Single submitter
-
BRF2 p.Ala93Thr
Uncertain significance
Single submitter
prostate cancer
- BRF2 p.Arg102Trp Uncertain significance Single submitter
- BRF2 p.Arg275Trp Uncertain significance Single submitter
- BRF2 p.Arg291Trp Uncertain significance Single submitter
- BRF2 p.Arg350Trp Uncertain significance Single submitter
- BRF2 p.Arg368Trp Uncertain significance Single submitter
- BRF2 p.Arg404Gly Uncertain significance Single submitter
- BRF2 p.Gly380Glu Uncertain significance Single submitter
- BRF2 p.Gly38Glu Uncertain significance Single submitter
- BRF2 p.Phe183Leu Uncertain significance Single submitter
- BRF2 p.Phe231Leu Uncertain significance Single submitter
- BRF2 p.Ser19Trp Uncertain significance Single submitter
- BRF2 p.Thr214Met Uncertain significance Single submitter
- BRF2 p.Thr379Ile Uncertain significance Single submitter
- BRF2 p.Tyr97His Uncertain significance Single submitter
All BRF2 variants
Likely benign 1
- p.Arg284Gln Single submitter
Uncertain significance 67
- p.Ala109Thr Single submitter ⚠
- p.Ala185Pro Single submitter ⚠
- p.Ala262Val Single submitter ⚠
- p.Ala317Gly Single submitter ⚠
- p.Ala352Ser Single submitter ⚠
- p.Ala405Ser Single submitter ⚠
- p.Ala93Thr Single submitter prostate cancer ⚠
- p.Arg102Trp Single submitter ⚠
- p.Arg127Gln Single submitter ⚠
- p.Arg203Gln Single submitter ⚠
- p.Arg265His Single submitter ⚠
- p.Arg275Leu Single submitter ⚠
- p.Arg275Trp Single submitter ⚠
- p.Arg291Trp Single submitter ⚠
- p.Arg304Gly Single submitter ⚠
- p.Arg304His Single submitter ⚠
- p.Arg309His Single submitter ⚠
- p.Arg313Trp Single submitter ⚠
- p.Arg350Trp Single submitter ⚠
- p.Arg368Gln Single submitter ⚠
- p.Arg368Trp Single submitter ⚠
- p.Arg394His Single submitter
- p.Arg394Pro Single submitter ⚠
- p.Arg404Gly Single submitter ⚠
- p.Arg67Cys Single submitter ⚠
- p.Arg74Gln Single submitter ⚠
- p.Asn212Ser Single submitter ⚠
- p.Asp46Glu Single submitter ⚠
- p.Gln206His Single submitter ⚠
- p.Gln331Leu Single submitter ⚠
- p.Gln410Arg Single submitter ⚠
- p.Glu61Gly Single submitter ⚠
- p.Gly330Arg Single submitter ⚠
- p.Gly334Glu Single submitter ⚠
- p.Gly344Ser Single submitter ⚠
- p.Gly380Glu Single submitter ⚠
- p.Gly38Glu Single submitter ⚠
- p.Leu307Val Single submitter ⚠
- p.Leu358Phe Single submitter ⚠
- p.Lys174Asn Single submitter ⚠
- p.Met205Val Single submitter ⚠
- p.Phe183Leu Single submitter ⚠
- p.Phe231Leu Single submitter ⚠
- p.Pro224Ala Single submitter ⚠
- p.Pro2Ser Single submitter ⚠
- p.Pro327Leu Single submitter ⚠
- p.Pro371Arg Single submitter ⚠
- p.Pro373His Single submitter ⚠
- p.Pro396Ser Single submitter ⚠
- p.Ser104Pro Single submitter ⚠
- p.Ser166Phe Single submitter ⚠
- p.Ser19Trp Single submitter ⚠
- p.Ser22Trp Single submitter
- p.Thr140Met Single submitter ⚠
- p.Thr214Met Single submitter ⚠
- p.Thr377Ile Single submitter ⚠
- p.Thr379Ile Single submitter ⚠
- p.Thr413Met Single submitter ⚠
- p.Thr54Ser Single submitter ⚠
- p.Thr88Ile Single submitter ⚠
- p.Tyr97His Single submitter ⚠
- p.Val116Met Single submitter ⚠
- p.Val194Met Single submitter ⚠
- p.Val225Ile Single submitter ⚠
- p.Val338Gly Single submitter ⚠
- p.Val35Leu Single submitter ⚠
- p.Val39Phe Single submitter ⚠