BRICD5 — 66 ClinVar variants
All ClinVar germline BRICD5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 57 flagged for review →
11 Likely benign · 55 Uncertain significance
Full BRICD5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 57
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 34
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- BRICD5 p.Ala43Val Uncertain significance Single submitter
- BRICD5 p.Ala90Thr Uncertain significance Single submitter
- BRICD5 p.Arg135Trp Uncertain significance Single submitter
- BRICD5 p.Arg194Gln Uncertain significance Single submitter
- BRICD5 p.Arg201Thr Uncertain significance Single submitter
- BRICD5 p.Arg67Gln Uncertain significance Single submitter
- BRICD5 p.Arg77Gln Uncertain significance Single submitter
- BRICD5 p.Asp156Asn Uncertain significance Single submitter
- BRICD5 p.Asp210Asn Uncertain significance Single submitter
- BRICD5 p.Asp228Tyr Uncertain significance Single submitter
- BRICD5 p.Cys185Gly Uncertain significance Single submitter
- BRICD5 p.Cys208Arg Uncertain significance Single submitter
- BRICD5 p.Gln161Glu Uncertain significance Single submitter
- BRICD5 p.Gln80Leu Uncertain significance Single submitter
- BRICD5 p.Glu197Ala Uncertain significance Single submitter
- BRICD5 p.Gly178Glu Uncertain significance Single submitter
- BRICD5 p.Gly50Glu Uncertain significance Single submitter
- BRICD5 p.His74Asn Uncertain significance Single submitter
- BRICD5 p.Ile211Ser Uncertain significance Single submitter
- BRICD5 p.Leu107Pro Uncertain significance Single submitter
- BRICD5 p.Met130Thr Uncertain significance Single submitter
- BRICD5 p.Met68Thr Uncertain significance Single submitter
- BRICD5 p.Pro199Ser Uncertain significance Single submitter
- BRICD5 p.Pro199Thr Uncertain significance Single submitter
- BRICD5 p.Pro214Leu Uncertain significance Single submitter
- BRICD5 p.Pro73Ser Uncertain significance Single submitter
- BRICD5 p.Ser169Gly Uncertain significance Single submitter
- BRICD5 p.Ser215Asn Uncertain significance Single submitter
- BRICD5 p.Ser5Gly Uncertain significance Single submitter
- BRICD5 p.Thr20Ser Uncertain significance Single submitter
- BRICD5 p.Trp104Ser Uncertain significance Single submitter
- BRICD5 p.Tyr206Ser Uncertain significance Single submitter
- BRICD5 p.Val18Leu Uncertain significance Single submitter
- BRICD5 p.Val84Met Uncertain significance Single submitter
Predictors split 23
The independent predictors disagree with each other — read with care.
- BRICD5 p.Ala43Asp Uncertain significance Single submitter
- BRICD5 p.Arg10Cys Uncertain significance Single submitter
- BRICD5 p.Arg118Cys Uncertain significance Single submitter
- BRICD5 p.Arg118His Uncertain significance Single submitter
- BRICD5 p.Arg128His Uncertain significance Single submitter
- BRICD5 p.Arg194Gly Uncertain significance Single submitter
- BRICD5 p.Arg194Trp Uncertain significance Single submitter
- BRICD5 p.Arg200Gly Uncertain significance Single submitter
- BRICD5 p.Arg203Trp Uncertain significance Single submitter
- BRICD5 p.Arg77Trp Likely benign Single submitter
- BRICD5 p.Asn216Thr Uncertain significance Single submitter
- BRICD5 p.Ile209Val Uncertain significance Single submitter
- BRICD5 p.Leu226His Uncertain significance Single submitter
- BRICD5 p.Pro174Ser Uncertain significance Single submitter
- BRICD5 p.Pro189Leu Uncertain significance Single submitter
- BRICD5 p.Pro71Leu Uncertain significance Single submitter
- BRICD5 p.Ser100Thr Uncertain significance Single submitter
- BRICD5 p.Ser215Cys Uncertain significance Single submitter
- BRICD5 p.Ser220Leu Uncertain significance Single submitter
- BRICD5 p.Thr65Met Likely benign Single submitter
- BRICD5 p.Thr96Asn Uncertain significance Single submitter
- BRICD5 p.Trp192Leu Uncertain significance Single submitter
- BRICD5 p.Val30Met Uncertain significance Single submitter
All BRICD5 variants
Likely benign 11
- p.Ala43Thr Single submitter
- p.Ala90Val Single submitter
- p.Arg139Gln Single submitter
- p.Arg183His Single submitter
- p.Arg187Lys Single submitter
- p.Arg77Trp Single submitter ⚠
- p.Arg88Gln Single submitter
- p.Glu2Lys Single submitter
- p.Pro78Ser Single submitter
- p.Thr16Ala Single submitter
- p.Thr65Met Single submitter ⚠
Uncertain significance 55
- p.Ala43Asp Single submitter ⚠
- p.Ala43Val Single submitter ⚠
- p.Ala90Thr Single submitter ⚠
- p.Arg10Cys Single submitter ⚠
- p.Arg118Cys Single submitter ⚠
- p.Arg118His Single submitter ⚠
- p.Arg128His Single submitter ⚠
- p.Arg135Trp Single submitter ⚠
- p.Arg194Gln Single submitter ⚠
- p.Arg194Gly Single submitter ⚠
- p.Arg194Trp Single submitter ⚠
- p.Arg200Gly Single submitter ⚠
- p.Arg201Thr Single submitter ⚠
- p.Arg203Trp Single submitter ⚠
- p.Arg67Gln Single submitter ⚠
- p.Arg77Gln Single submitter ⚠
- p.Asn216Thr Single submitter ⚠
- p.Asp156Asn Single submitter ⚠
- p.Asp210Asn Single submitter ⚠
- p.Asp228Tyr Single submitter ⚠
- p.Cys185Gly Single submitter ⚠
- p.Cys208Arg Single submitter ⚠
- p.Gln161Glu Single submitter ⚠
- p.Gln80Leu Single submitter ⚠
- p.Glu197Ala Single submitter ⚠
- p.Gly178Glu Single submitter ⚠
- p.Gly50Glu Single submitter ⚠
- p.His74Asn Single submitter ⚠
- p.Ile209Val Single submitter ⚠
- p.Ile211Ser Single submitter ⚠
- p.Leu107Pro Single submitter ⚠
- p.Leu226His Single submitter ⚠
- p.Met130Thr Single submitter ⚠
- p.Met68Thr Single submitter ⚠
- p.Pro174Ser Single submitter ⚠
- p.Pro189Leu Single submitter ⚠
- p.Pro199Ser Single submitter ⚠
- p.Pro199Thr Single submitter ⚠
- p.Pro214Leu Single submitter ⚠
- p.Pro71Leu Single submitter ⚠
- p.Pro73Ser Single submitter ⚠
- p.Ser100Thr Single submitter ⚠
- p.Ser169Gly Single submitter ⚠
- p.Ser215Asn Single submitter ⚠
- p.Ser215Cys Single submitter ⚠
- p.Ser220Leu Single submitter ⚠
- p.Ser5Gly Single submitter ⚠
- p.Thr20Ser Single submitter ⚠
- p.Thr96Asn Single submitter ⚠
- p.Trp104Ser Single submitter ⚠
- p.Trp192Leu Single submitter ⚠
- p.Tyr206Ser Single submitter ⚠
- p.Val18Leu Single submitter ⚠
- p.Val30Met Single submitter ⚠
- p.Val84Met Single submitter ⚠