BRINP1 — 7 ClinVar variants
All ClinVar germline BRINP1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 2 flagged for review →
2 Benign · 1 Benign/Likely benign · 2 Likely benign · 2 Uncertain significance
Full BRINP1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 2
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 1
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 1
The independent predictors disagree with each other — read with care.
All BRINP1 variants
Benign 2
- p.Ala270= Multiple submitters
- p.Ser641Leu Multiple submitters
Benign/Likely benign 1
- p.Ser572= Multiple submitters
Likely benign 2
- p.Arg411Gln Multiple submitters
- p.Thr349Met Single submitter
Uncertain significance 2
- p.Gly543Ser Single submitter ⚠
- p.Lys759Glu Single submitter ⚠