BRINP2 — 107 ClinVar variants
All ClinVar germline BRINP2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 106 flagged for review →
1 Benign · 1 Likely benign · 105 Uncertain significance
Full BRINP2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 106
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 72
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- BRINP2 p.Ala342Thr Uncertain significance Single submitter
- BRINP2 p.Ala363Gly Uncertain significance Single submitter
- BRINP2 p.Ala465Thr Uncertain significance Single submitter
- BRINP2 p.Ala465Val Uncertain significance Single submitter
- BRINP2 p.Ala467Thr Uncertain significance Single submitter
- BRINP2 p.Ala50Thr Uncertain significance Single submitter
- BRINP2 p.Ala50Val Uncertain significance Single submitter
- BRINP2 p.Arg104Lys Uncertain significance Single submitter
- BRINP2 p.Arg120Gln Uncertain significance Single submitter
- BRINP2 p.Arg210Gln Uncertain significance Single submitter
- BRINP2 p.Arg211Gln Uncertain significance Single submitter
- BRINP2 p.Arg271His Uncertain significance Single submitter
- BRINP2 p.Arg332Gln Uncertain significance Single submitter
- BRINP2 p.Arg351Gln Uncertain significance Single submitter
- BRINP2 p.Arg402His Uncertain significance Single submitter
- BRINP2 p.Arg407His Uncertain significance Single submitter
- BRINP2 p.Arg476His Uncertain significance Single submitter
- BRINP2 p.Arg537Gln Uncertain significance Single submitter
- BRINP2 p.Arg726Gly Uncertain significance Single submitter
- BRINP2 p.Arg737Gln Uncertain significance Single submitter
- BRINP2 p.Arg85Lys Uncertain significance Single submitter
- BRINP2 p.Arg94His Uncertain significance Single submitter
- BRINP2 p.Asn395His Uncertain significance Single submitter
- BRINP2 p.Asn617Thr Uncertain significance Single submitter
- BRINP2 p.Asp106Glu Uncertain significance Single submitter
- BRINP2 p.Asp204Tyr Uncertain significance Single submitter
- BRINP2 p.Asp349Ala Uncertain significance Single submitter
- BRINP2 p.Asp61Glu Uncertain significance Single submitter
- BRINP2 p.Asp655Asn Uncertain significance Single submitter
- BRINP2 p.Asp695Glu Uncertain significance Single submitter
- BRINP2 p.Cys295Phe Uncertain significance Single submitter
- BRINP2 p.Cys427Tyr Uncertain significance Single submitter
- BRINP2 p.Gln196Pro Uncertain significance Single submitter
- BRINP2 p.Gln261Pro Uncertain significance Single submitter
- BRINP2 p.Gln684Lys Uncertain significance Single submitter
- BRINP2 p.Gln710Glu Uncertain significance Single submitter
- BRINP2 p.Glu266Ala Uncertain significance Single submitter
- BRINP2 p.Glu607Lys Uncertain significance Single submitter
- BRINP2 p.Glu755Asp Uncertain significance Single submitter
- BRINP2 p.Gly11Arg Uncertain significance Single submitter
- BRINP2 p.Gly181Arg Uncertain significance Single submitter
- BRINP2 p.Gly779Ser Uncertain significance Single submitter
- BRINP2 p.His370Arg Uncertain significance Single submitter
- BRINP2 p.Ile203Val Uncertain significance Single submitter
- BRINP2 p.Ile280Val Uncertain significance Single submitter
- BRINP2 p.Ile313Thr Uncertain significance Single submitter
- BRINP2 p.Ile389Leu Uncertain significance Single submitter
- BRINP2 p.Ile721Thr Uncertain significance Single submitter
- BRINP2 p.Leu112Val Uncertain significance Single submitter
- BRINP2 p.Leu55Arg Uncertain significance Single submitter
- BRINP2 p.Lys140Arg Uncertain significance Single submitter
- BRINP2 p.Lys166Glu Uncertain significance Single submitter
- BRINP2 p.Met364Arg Uncertain significance Single submitter
- BRINP2 p.Met668Ile Uncertain significance Single submitter
- BRINP2 p.Phe65Ile Uncertain significance Single submitter
- BRINP2 p.Pro14Ser Uncertain significance Single submitter
- BRINP2 p.Ser109Thr Uncertain significance Single submitter
- BRINP2 p.Ser245Phe Uncertain significance Single submitter
- BRINP2 p.Ser326Thr Uncertain significance Single submitter
- BRINP2 p.Ser359Ala Uncertain significance Single submitter
- BRINP2 p.Ser367Arg Uncertain significance Single submitter
- BRINP2 p.Ser442Arg Uncertain significance Single submitter
- BRINP2 p.Thr187Lys Uncertain significance Single submitter
- BRINP2 p.Trp627Cys Uncertain significance Single submitter
- BRINP2 p.Tyr447Cys Uncertain significance Single submitter
- BRINP2 p.Tyr662Phe Uncertain significance Single submitter
- BRINP2 p.Val134Phe Uncertain significance Single submitter
- BRINP2 p.Val262Leu Uncertain significance Single submitter
- BRINP2 p.Val495Met Uncertain significance Single submitter
- BRINP2 p.Val590Ile Uncertain significance Single submitter
- BRINP2 p.Val618Met Uncertain significance Single submitter
- BRINP2 p.Val736Ile Uncertain significance Single submitter
Predictors split 34
The independent predictors disagree with each other — read with care.
- BRINP2 p.Arg269His Uncertain significance Single submitter
- BRINP2 p.Arg332Trp Uncertain significance Single submitter
- BRINP2 p.Arg351Trp Uncertain significance Single submitter
- BRINP2 p.Arg407Cys Uncertain significance Single submitter
- BRINP2 p.Arg524His Uncertain significance Single submitter
- BRINP2 p.Arg549His Uncertain significance Single submitter
- BRINP2 p.Arg647Gln Uncertain significance Single submitter
- BRINP2 p.Arg87Lys Uncertain significance Single submitter
- BRINP2 p.Asn99Tyr Uncertain significance Single submitter
- BRINP2 p.Asp695His Uncertain significance Single submitter
- BRINP2 p.Asp705Asn Uncertain significance Single submitter
- BRINP2 p.Gln373His Uncertain significance Single submitter
- BRINP2 p.Gln80His Uncertain significance Single submitter
- BRINP2 p.Glu136Gly Uncertain significance Single submitter
- BRINP2 p.Glu156Asp Uncertain significance Single submitter
- BRINP2 p.Glu287Lys Uncertain significance Single submitter
- BRINP2 p.Glu411Asp Uncertain significance Single submitter
- BRINP2 p.Glu667Lys Uncertain significance Single submitter
- BRINP2 p.Gly181Trp Uncertain significance Single submitter
- BRINP2 p.Gly608Ser Uncertain significance Single submitter
- BRINP2 p.Ile421Val Uncertain significance Single submitter
- BRINP2 p.Leu723Phe Uncertain significance Single submitter
- BRINP2 p.Met550Val Uncertain significance Single submitter
- BRINP2 p.Phe406Leu Uncertain significance Single submitter
- BRINP2 p.Phe638Val Uncertain significance Single submitter
- BRINP2 p.Pro304Leu Uncertain significance Single submitter
- BRINP2 p.Pro482Leu Uncertain significance Single submitter
- BRINP2 p.Ser244Asn Uncertain significance Single submitter
- BRINP2 p.Ser474Cys Uncertain significance Single submitter
- BRINP2 p.Ser731Thr Uncertain significance Single submitter
- BRINP2 p.Thr507Ile Uncertain significance Single submitter
- BRINP2 p.Val255Leu Uncertain significance Single submitter
- BRINP2 p.Val289Ile Likely benign Single submitter
- BRINP2 p.Val774Met Uncertain significance Single submitter
All BRINP2 variants
Benign 1
- p.Tyr279= Multiple submitters
Likely benign 1
- p.Val289Ile Single submitter ⚠
Uncertain significance 105
- p.Ala342Thr Single submitter ⚠
- p.Ala363Gly Single submitter ⚠
- p.Ala465Thr Single submitter ⚠
- p.Ala465Val Single submitter ⚠
- p.Ala467Thr Single submitter ⚠
- p.Ala50Thr Single submitter ⚠
- p.Ala50Val Single submitter ⚠
- p.Arg104Lys Single submitter ⚠
- p.Arg120Gln Single submitter ⚠
- p.Arg210Gln Single submitter ⚠
- p.Arg211Gln Single submitter ⚠
- p.Arg269His Single submitter ⚠
- p.Arg271His Single submitter ⚠
- p.Arg332Gln Single submitter ⚠
- p.Arg332Trp Single submitter ⚠
- p.Arg351Gln Single submitter ⚠
- p.Arg351Trp Single submitter ⚠
- p.Arg402His Single submitter ⚠
- p.Arg407Cys Single submitter ⚠
- p.Arg407His Single submitter ⚠
- p.Arg476His Single submitter ⚠
- p.Arg524His Single submitter ⚠
- p.Arg537Gln Single submitter ⚠
- p.Arg549His Single submitter ⚠
- p.Arg647Gln Single submitter ⚠
- p.Arg726Gly Single submitter ⚠
- p.Arg737Gln Single submitter ⚠
- p.Arg85Lys Single submitter ⚠
- p.Arg87Lys Single submitter ⚠
- p.Arg94His Single submitter ⚠
- p.Asn395His Single submitter ⚠
- p.Asn617Thr Single submitter ⚠
- p.Asn99Tyr Single submitter ⚠
- p.Asp106Glu Single submitter ⚠
- p.Asp204Tyr Single submitter ⚠
- p.Asp349Ala Single submitter ⚠
- p.Asp61Glu Single submitter ⚠
- p.Asp655Asn Single submitter ⚠
- p.Asp695Glu Single submitter ⚠
- p.Asp695His Single submitter ⚠
- p.Asp705Asn Single submitter ⚠
- p.Cys295Phe Single submitter ⚠
- p.Cys427Tyr Single submitter ⚠
- p.Gln196Pro Single submitter ⚠
- p.Gln261Pro Single submitter ⚠
- p.Gln373His Single submitter ⚠
- p.Gln684Lys Single submitter ⚠
- p.Gln710Glu Single submitter ⚠
- p.Gln80His Single submitter ⚠
- p.Glu136Gly Single submitter ⚠
- p.Glu156Asp Single submitter ⚠
- p.Glu266Ala Single submitter ⚠
- p.Glu287Lys Single submitter ⚠
- p.Glu411Asp Single submitter ⚠
- p.Glu607Lys Single submitter ⚠
- p.Glu667Lys Single submitter ⚠
- p.Glu755Asp Single submitter ⚠
- p.Gly11Arg Single submitter ⚠
- p.Gly181Arg Single submitter ⚠
- p.Gly181Trp Single submitter ⚠
- p.Gly608Ser Single submitter ⚠
- p.Gly779Ser Single submitter ⚠
- p.His370Arg Single submitter ⚠
- p.Ile203Val Single submitter ⚠
- p.Ile280Val Single submitter ⚠
- p.Ile313Thr Single submitter ⚠
- p.Ile389Leu Single submitter ⚠
- p.Ile421Val Single submitter ⚠
- p.Ile721Thr Single submitter ⚠
- p.Leu112Val Single submitter ⚠
- p.Leu55Arg Single submitter ⚠
- p.Leu723Phe Single submitter ⚠
- p.Lys140Arg Single submitter ⚠
- p.Lys166Glu Single submitter ⚠
- p.Met364Arg Single submitter ⚠
- p.Met550Val Single submitter ⚠
- p.Met668Ile Single submitter ⚠
- p.Phe406Leu Single submitter ⚠
- p.Phe638Val Single submitter ⚠
- p.Phe65Ile Single submitter ⚠
- p.Pro14Ser Single submitter ⚠
- p.Pro304Leu Single submitter ⚠
- p.Pro482Leu Single submitter ⚠
- p.Ser109Thr Single submitter ⚠
- p.Ser244Asn Single submitter ⚠
- p.Ser245Phe Single submitter ⚠
- p.Ser326Thr Single submitter ⚠
- p.Ser359Ala Single submitter ⚠
- p.Ser367Arg Single submitter ⚠
- p.Ser442Arg Single submitter ⚠
- p.Ser474Cys Single submitter ⚠
- p.Ser731Thr Single submitter ⚠
- p.Thr187Lys Single submitter ⚠
- p.Thr507Ile Single submitter ⚠
- p.Trp627Cys Single submitter ⚠
- p.Tyr447Cys Single submitter ⚠
- p.Tyr662Phe Single submitter ⚠
- p.Val134Phe Single submitter ⚠
- p.Val255Leu Single submitter ⚠
- p.Val262Leu Single submitter ⚠
- p.Val495Met Single submitter ⚠
- p.Val590Ile Single submitter ⚠
- p.Val618Met Single submitter ⚠
- p.Val736Ile Single submitter ⚠
- p.Val774Met Single submitter ⚠