BRME1 — 10 ClinVar variants
All ClinVar germline BRME1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 5 flagged for review →
1 Benign · 4 Likely benign · 5 Uncertain significance
Full BRME1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 5
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 5
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
All BRME1 variants
Benign 1
- c.-184A>G Single submitter
Likely benign 4
- p.Arg620Trp Single submitter
- p.Arg638Gln Single submitter
- p.Asp491Glu Single submitter
- p.Val304= Single submitter
Uncertain significance 5
- p.Ala353Pro Single submitter ⚠
- p.Ala547Thr Single submitter ⚠
- p.Ala66Thr Single submitter ⚠
- p.Asp168Gly Single submitter ⚠
- p.Asp192Glu Single submitter ⚠