BRMS1 — 51 ClinVar variants
All ClinVar germline BRMS1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 34 flagged for review →
2 Benign · 4 Likely benign · 45 Uncertain significance
Full BRMS1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 34
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 23
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- BRMS1 p.Ala15Val Uncertain significance Single submitter
- BRMS1 p.Ala187Thr Uncertain significance Single submitter
- BRMS1 p.Ala235Thr Uncertain significance Single submitter
- BRMS1 p.Arg87Gln Uncertain significance Single submitter
- BRMS1 p.Arg89Gln Uncertain significance Single submitter
- BRMS1 p.Asp183Asn Uncertain significance Single submitter
- BRMS1 p.Glu16Asp Uncertain significance Single submitter
- BRMS1 p.Glu219Lys Uncertain significance Single submitter
- BRMS1 p.Glu29Asp Uncertain significance Single submitter
- BRMS1 p.Gly106Val Uncertain significance Single submitter
- BRMS1 p.Gly158Arg Uncertain significance Single submitter
- BRMS1 p.Ile121Val Uncertain significance Single submitter
- BRMS1 p.Ile220Leu Uncertain significance Single submitter
- BRMS1 p.Lys113Arg Uncertain significance Single submitter
- BRMS1 p.Lys142Thr Uncertain significance Single submitter
- BRMS1 p.Lys230Arg Uncertain significance Single submitter
- BRMS1 p.Lys77Gln Uncertain significance Single submitter
- BRMS1 p.Ser237Phe Uncertain significance Single submitter
- BRMS1 p.Ser35Gly Uncertain significance Single submitter
- BRMS1 p.Thr39Ala Uncertain significance Single submitter
- BRMS1 p.Tyr153Cys Uncertain significance Single submitter
- BRMS1 p.Tyr53Cys Uncertain significance Single submitter
- BRMS1 p.Val214Met Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- BRMS1 p.Arg171His Uncertain significance Single submitter
- BRMS1 p.Arg89Trp Uncertain significance Single submitter
- BRMS1 p.Asp221Asn Uncertain significance Single submitter
- BRMS1 p.Asp50His Uncertain significance Single submitter
- BRMS1 p.Gln70His Uncertain significance Single submitter
- BRMS1 p.Glu63Lys Uncertain significance Single submitter
- BRMS1 p.Lys123Glu Uncertain significance Single submitter
- BRMS1 p.Lys242Asn Uncertain significance Single submitter
- BRMS1 p.Met216Thr Uncertain significance Single submitter
- BRMS1 p.Phe125Leu Uncertain significance Single submitter
- BRMS1 p.Ser72Leu Uncertain significance Single submitter
All BRMS1 variants
Likely benign 4
Uncertain significance 45
- c.*105G>C Single submitter
- c.*111C>T Single submitter
- c.*113A>G Single submitter
- c.*122T>A Single submitter
- c.*126G>T Single submitter
- c.*135C>T Single submitter
- c.*167C>A Single submitter
- c.*177C>T Single submitter
- c.*95C>T Single submitter
- p.Ala15Val Single submitter ⚠
- p.Ala187Thr Single submitter ⚠
- p.Ala235Thr Single submitter ⚠
- p.Arg171His Single submitter ⚠
- p.Arg87Gln Single submitter ⚠
- p.Arg89Gln Single submitter ⚠
- p.Arg89Leu Single submitter
- p.Arg89Trp Single submitter ⚠
- p.Asp183Asn Single submitter ⚠
- p.Asp221Asn Single submitter ⚠
- p.Asp50His Single submitter ⚠
- p.Gln70His Single submitter ⚠
- p.Glu16Asp Single submitter ⚠
- p.Glu219Lys Single submitter ⚠
- p.Glu29Asp Single submitter ⚠
- p.Glu63Lys Single submitter ⚠
- p.Gly106Val Single submitter ⚠
- p.Gly158Arg Single submitter ⚠
- p.Ile121Val Single submitter ⚠
- p.Ile220Leu Single submitter ⚠
- p.Lys113Arg Single submitter ⚠
- p.Lys123Glu Single submitter ⚠
- p.Lys142Thr Single submitter ⚠
- p.Lys230Arg Single submitter ⚠
- p.Lys242Asn Single submitter ⚠
- p.Lys77Gln Single submitter ⚠
- p.Met216Thr Single submitter ⚠
- p.Phe125Leu Single submitter ⚠
- p.Ser178Phe Single submitter
- p.Ser237Phe Single submitter ⚠
- p.Ser35Gly Single submitter ⚠
- p.Ser72Leu Single submitter ⚠
- p.Thr39Ala Single submitter ⚠
- p.Tyr153Cys Single submitter ⚠
- p.Tyr53Cys Single submitter ⚠
- p.Val214Met Single submitter ⚠